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Senior Clinical Data Manager Jobs (NOW HIRING)

Alnylam

Senior Clinical Data Manager The Senior Clinical Data Manager will lead and contribute to data management activities in support of Alnylam studies across all stages of clinical drug development. This ...

EBR Systems, Inc.

Sr. Clinical Data Manager

The Clinical Data Manager (or Senior Clinical Data Manager, based on experience) will lead database development and management efforts - encompassing EDC, eTMF, and CTMS systems - in close ...

Artivion

Sr. Clinical Data Manager

Kennesaw, GA

The Sr. Clinical Data Manager is responsible for data management operations and for the organization, coordination and execution of data management activities for assigned studies and projects. This ...

CryoLife

Sr. Clinical Data Manager

Kennesaw, GA · On-site

The Sr. Clinical Data Manager is responsible for data management operations and for the organization, coordination and execution of data management activities for assigned studies and projects. This ...

AstraZeneca

Senior Clinical Data Manager II

Durham, NC · On-site

In this role as a Senior Clinical Data Manager II, you will be responsible for coordination of the Clinical Data Management (CDM) deliverables on assigned clinical studies and may be an expert on CDM ...

Clinovo

Senior Data Manager

Palo Alto, CA · On-site

$130K/yr

Senior Clinical Data Manager Role Overview The Senior Clinical Data Manager will play a critical role in database development, data quality oversight, and vendor coordination to ensure accurate ...

AstraZeneca

Senior Clinical Data Manager II

Durham, NC · On-site

In this role as a Senior Clinical Data Manager II, you will be responsible for coordination of the Clinical Data Management (CDM) deliverables on assigned clinical studies and may be an expert on CDM ...

AstraZeneca

Senior Clinical Data Manager II

Durham, NC · On-site

In this role as a Senior Clinical Data Manager II, you will be responsible for coordination of the Clinical Data Management (CDM) deliverables on assigned clinical studies and may be an expert on CDM ...

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How much do senior clinical data manager jobs pay per year?

As of May 27, 2026, the average yearly pay for senior clinical data manager in the United States is $123,055.00, according to ZipRecruiter salary data. Most workers in this role earn between $104,500.00 and $137,500.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Senior Clinical Data Manager, and why are they important?

To thrive as a Senior Clinical Data Manager, you need a solid background in clinical research, data management practices, and a relevant degree such as life sciences or computer science. Familiarity with clinical data management systems (CDMS), electronic data capture (EDC) platforms, and knowledge of regulatory guidelines like GCP are essential, along with certifications such as CCDM. Strong leadership, analytical thinking, attention to detail, and excellent communication skills set top performers apart in this role. These skills ensure data integrity, regulatory compliance, and effective collaboration across cross-functional clinical teams, which are critical to the success of clinical trials.

How does a Senior Clinical Data Manager typically collaborate with cross-functional teams during a clinical trial?

As a Senior Clinical Data Manager, you will work closely with clinical operations, biostatistics, medical writers, and regulatory teams throughout the lifecycle of a clinical trial. Your responsibilities often include coordinating data collection processes, ensuring data integrity, and resolving discrepancies by communicating with site monitors and data entry staff. Regular meetings and updates are common to align on data review timelines, discuss protocol amendments, and address any data-related issues swiftly. This high level of collaboration helps ensure that the clinical trial runs smoothly and meets regulatory standards.

What does a Senior Clinical Data Manager do?

A Senior Clinical Data Manager oversees the collection, validation, and management of clinical trial data to ensure its accuracy, integrity, and compliance with regulatory standards. They design and implement data management plans, coordinate with clinical teams, monitor data quality, and resolve discrepancies. In addition, they may lead data management teams and play a key role in preparing data for statistical analysis and regulatory submissions. Their work is crucial for supporting clinical research and ensuring reliable study results.

What is the difference between Senior Clinical Data Manager vs Clinical Data Coordinator?

AspectSenior Clinical Data ManagerClinical Data Coordinator
CredentialsBachelor's/Master's in Life Sciences, Biostatistics, or related field; experience in data managementBachelor's degree in Life Sciences or related field; entry-level experience
Work EnvironmentLeads data management teams, oversees data quality, and ensures complianceSupports data entry, validation, and basic data queries
Industry UsageUsed in pharmaceutical, biotech, and clinical research organizationsCommon in clinical trial sites and research organizations

The Senior Clinical Data Manager typically has more experience, oversees data management processes, and ensures data quality, while the Clinical Data Coordinator handles data entry and validation tasks. Both roles are essential in clinical research but differ in responsibility level and scope.

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Senior Clinical Data Manager jobs near you
Infographic showing various Senior Clinical Data Manager job openings in the United States as of May 2026, with employment types broken down into 1% As Needed, 84% Full Time, 12% Part Time, 1% Temporary, and 2% Contract. Highlights an 78% Physical, 2% Hybrid, and 20% Remote job distribution, with an average salary of $123,055 per year, or $59.2 per hour.

Senior Clinical Data Manager

Alnylam

Full-time

Posted 10 days ago

Job description

Senior Clinical Data Manager

The Senior Clinical Data Manager will lead and contribute to data management activities in support of Alnylam studies across all stages of clinical drug development. This position reports to the Senior Manager, Data Management.

Summary of Key Responsibilities:

  • Contribute to data management activities as a lead study data manager in support of Alnylam clinical studies
  • Lead database build activities including leading cross-functional review of eCRF content, review of edit check specifications, and perform user acceptance testing
  • Monitor data collection, coding, and cleaning by vendors through tracking of study metrics and targeted data reviews
  • Oversight of database lock activities and ultimate archiving of study data
  • Collaborate with internal and external partners, including Biostatistics, Statistical Programming, Clinical Operations, Medical, Quality Assurance, Global Patient Safety and Risk Management, and Regulatory Affairs; CROs, central and local laboratories, and other vendors
  • Establish cross-functional, internal data review plans, coordinate data cuts/transfers, and conduct data reviews
  • Review CRO data management plans, CRF completion guidelines, external data transfer specifications and other study documentation
  • Contribute to development and implementation of department workflows and infrastructure strategy (such as preferred provider interactions, SOPs, and templates) that reflects data collection standards, consistent with industry best practice and regulation
  • Represent data management and effectively communicate requirements, strategy, timelines and deliverables at internal cross-functional team meetings and meetings with external vendors
  • Participate in the training of external vendors and site staff
  • Participate in the drafting and/or review of timelines consistent with company goals and ensure all deliverables and milestones are met
  • Review clinical protocols/amendments, clinical study reports, statistical analysis plans, etc.
  • Support GCP inspection readiness
  • Demonstrate clear alignment with Alnylam Core Values including, Commitment to People, Innovation and Discovery, Sense of Urgency, Open Culture and Passion for Excellence

Qualifications:

  • BS/BA in scientific discipline
  • Extensive related experience in a pharmaceutical/biologics/biotechnology company
  • Experience working in clinical drug development through Phase 3 in an outsourced CRO model; experience with drug development in rare genetic diseases preferred
  • Expert knowledge of eClinical processes, efficient design/build of an EDC data management system and other Clinical Trial/Data Management Systems
  • Knowledge and understanding of regulations and industry/adopted data standards such as CDISC, SDTM, and CDASH
  • Experience working with Oracle InForm and Medidata Rave
  • Experience using standardized medical terminology, including MedDRA and WHODrug
  • Experience working with MSOffice Suite (Excel, Word, PowerPoint) and familiarity with MS Project
  • Excellent written and oral communications skills
  • Highly motivated and flexible, with excellent organizational and time management skills
  • Ability to work independently and as part of a multi-disciplinary team
  • Understanding of ICH GCP as well as general knowledge of industry practices and standards
  • Knowledge and understanding of regulatory requirements and expectations for clinical data systems including 21 CFR Part 11 NDA/MAA experience

Alnylam Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.

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