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Research Protein Purification Jobs (NOW HIRING)

System One

Protein Expression Scientist - Temp

Alameda, CA · On-site

$50 - $55/hr

This hands-on laboratory role requires expertise in molecular biology, protein expression systems, and chromatographic purification methods, with opportunities to contribute across multiple research ...

System One

Protein Expression Scientist - Temp

Alameda, CA · On-site

$50 - $55/hr

This hands-on laboratory role requires expertise in molecular biology, protein expression systems, and chromatographic purification methods, with opportunities to contribute across multiple research ...

System One

Protein Expression Scientist - Temp

Alameda, CA · On-site

$50 - $55/hr

This hands-on laboratory role requires expertise in molecular biology, protein expression systems, and chromatographic purification methods, with opportunities to contribute across multiple research ...

Caltech

Research Technician

Pasadena, CA · On-site

$19 - $25.75/hr

Harvest cells and assist with downstream, protein purification (modern chromatography methods ... Support researchers with other tasks as needed. Basic Qualifications * Bachelor's degree in Biology ...

UNC-Chapel Hill

Research Technician

Chapel Hill, NC · On-site

$20/hr

Recent, hands-on experience with protein purification methods. Recent experience with recombinant protein expression and purification from E. coli. Strong organizational skills with attention to ...

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Research Protein Purification information

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How much do research protein purification jobs pay per hour?

As of Aug 16, 2026, the average hourly pay for research protein purification in the United States is $22.22, according to ZipRecruiter salary data. Most workers in this role earn between $17.31 and $23.80 per hour, depending on experience, location, and employer.

What is the difference between Research Protein Purification vs Research Biochemistry Technician?

AspectResearch Protein PurificationResearch Biochemistry Technician
CredentialsBachelor's or Master's in Biochemistry, Molecular Biology, or related fieldsBachelor's degree in Biochemistry, Chemistry, or related sciences
Work EnvironmentLaboratories focused on protein isolation, purification, and analysisLaboratories conducting biochemical experiments, sample preparation, and analysis
Industry UsagePharmaceutical, biotech, academic researchResearch institutions, biotech companies, academic labs
Common Search/ComparisonResearch Protein PurificationResearch Biochemistry Technician

Research Protein Purification specialists focus specifically on isolating and purifying proteins for experiments, often requiring specialized techniques and equipment. Research Biochemistry Technicians perform broader biochemical tasks, including sample preparation and analysis. While both roles work in laboratory settings within similar industries, their core responsibilities and skill sets differ slightly, with protein purification being more specialized.

What are some common challenges faced during protein purification in a research setting, and how can they be addressed?

One common challenge in research protein purification is maintaining protein stability and activity throughout the process, as proteins can denature or degrade easily. Another issue is achieving sufficient yield and purity, especially when working with low-expression proteins or complex mixtures. Overcoming these challenges often involves optimizing buffer conditions, choosing the right purification methods (such as affinity, ion-exchange, or size-exclusion chromatography), and troubleshooting at each step. Collaborating closely with colleagues in molecular biology, biochemistry, and analytical teams is also essential for problem-solving and method development.

What is research protein purification?

Research protein purification is the process of isolating a specific protein from a complex mixture, such as cells or tissues, for study or use in experiments. This process involves several steps, including extraction, separation, and analysis, to obtain a highly pure and functional protein. Protein purification is crucial in biochemical and pharmaceutical research, as it enables scientists to study protein structure, function, and interactions. Techniques used include chromatography, electrophoresis, and centrifugation, among others. Mastery of protein purification methods is essential for producing proteins for drug development, diagnostics, and basic research.

What are the key skills and qualifications needed to thrive in research protein purification?

To excel in Research Protein Purification, you need a solid background in biochemistry or molecular biology, hands-on laboratory experience, and a relevant degree such as a BSc, MSc, or PhD. Familiarity with chromatographic systems (e.g., FPLC, HPLC), protein characterization methods, and software for data analysis is typically required. Attention to detail, analytical thinking, and effective communication are crucial soft skills for troubleshooting and collaborating with research teams. These competencies ensure the reliable isolation and analysis of proteins, which are fundamental for advancing scientific research and therapeutic development.
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Research Protein Purification jobs near you
Infographic showing various Research Protein Purification job openings in the United States as of August 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $46,222 per year, or $22.2 per hour.

Senior Research Associate, Protein Sciences (Contract role)

Septerna

South San Francisco, CA • On-site

$36/hr

Full-time

Re-posted 11 days ago

Job description

Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company. The company's Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables novel access to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs. Septerna has an emerging pipeline of GPCR-targeted small molecule programs with potential for growth to target many GPCRs that have been undruggable and unexploited to date.
We are excited to expand our multidisciplinary team of individuals focused on creating revolutionary medicines to address the unmet needs of patients. At Septerna we strive to embrace diversity of thought, expertise, and background through collaboration. To join our ambitious team, be prepared to bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to accomplish our mission. We share a fearless pursuit of ground-breaking innovations and cultivate an environment where our employees succeed by learning from each other and working as a team.
We are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the frontlines of therapeutic discovery and development. You will directly help move therapies through preclinical research, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team motivated to discover new disease-modifying therapeutics for patients in a fast-paced environment.
For more information see: www.septerna.com.
THE ROLE
We are seeking passionate and creative individuals who want to contribute to Septerna's mission to utilize innovative drug discovery technologies for GPCR targets. The ideal candidate will have experience in protein purification using a variety of methods including fast-performance liquid chromatography (FPLC), microscale purification, and magnetic bead-based purification.
The chosen candidate will be working in a collaborative team contributing to medium and large-scale protein production and characterization for use in structural biology, biophysics, and small molecule drug discovery. This position offers the unique opportunity to join an innovative well-funded biotechnology company and to contribute to its long-term success.
The position is based in South San Franscisco, CA. Title and compensation commensurate with experience.
***40 hrs/week, one year contract role***
Responsibilities
  • Perform as a hands-on protein production associate to help fully enable Septerna's Native Complex™
  • Carry out medium and large-scale protein production utilizing a variety of techniques including FPLC, gravity flow, microscale, and magnetic bead purification
  • Qualify proteins utilizing techniques including SDS-PAGE, flow cytometry, fluorescent SEC, and DSF.
  • Work collaboratively with Discovery Biology teams in ensuring proper prioritization and timelines of cell culture requests.
  • Laboratory notebooking, data analysis and documentation.

Qualifications
  • BS with 4+ years of hands-on relevant experience in a biotechnology or pharmaceutical setting.
  • 2+ years demonstrated expertise in large-scale protein purification
  • Experience with affinity chromatography, ion-exchange chromatography, size exclusion chromatography, and SDS-PAGE
  • Prior experience with basic protein quality control techniques (SDS-PAGE, fSEC, DSF) is desirable.
  • Ability to write and follow standard operating procedures to ensure high-quality protein reagent production.
  • Strong skills in carrying out multiple simultaneous projects to ensure delivery of reagents with appropriate prioritization and timelines
  • Demonstrated experience working collaboratively in a team-oriented environment
  • Clear and effective verbal and written communication skills

The anticipated salary range for candidates who will work in South San Francisco, CA is $36/hr - 45/hr pay rate . Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training.
Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited. We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Septerna participates in the E-Verify program. California Consumer Privacy Act Privacy Notice For Job Applicants. If you are a California resident, click here for our CCPA Notice.

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