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Research Protein Purification Jobs (NOW HIRING)

Caltech

Research Technician

Pasadena, CA · On-site

$19 - $25.75/hr

Harvest cells and assist with downstream, protein purification (modern chromatography methods ... Support researchers with other tasks as needed. Basic Qualifications * Bachelor's degree in Biology ...

UNC-Chapel Hill

Research Technician

Chapel Hill, NC

$20/hr

Recent, hands-on experience with protein purification methods. Recent experience with recombinant protein expression and purification from E. coli. Strong organizational skills with attention to ...

Cape Fox SS

Scientist - NIH VRC

Bethesda, MD · On-site

$53.33/hr

Develop research findings and make recommendations to leadership for decision. Provide forward ... Column chromatography for protein purification by AEX, CEX, affinity, SEC, HIC. Column packing and ...

Ohio State University

Research Technician

Columbus, OH

$20.74/hr

Research Technician Department:Veterinary Medicine | Veterinary Biosciences The Xu Lab at the ... Conduct protein expression and purification in bacterial, insect, and mammalian systems. * Operate ...

3 Key Consulting

... research facility. PE is a multidisciplinary team with broad capabilities in protein engineering, expression, purification, and characterization. The ideal candidate should have a strong background ...

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Research Protein Purification information

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How much do research protein purification jobs pay per hour?

As of Jul 4, 2026, the average hourly pay for research protein purification in the United States is $22.22, according to ZipRecruiter salary data. Most workers in this role earn between $17.31 and $23.80 per hour, depending on experience, location, and employer.

What is the difference between Research Protein Purification vs Research Biochemistry Technician?

AspectResearch Protein PurificationResearch Biochemistry Technician
CredentialsBachelor's or Master's in Biochemistry, Molecular Biology, or related fieldsBachelor's degree in Biochemistry, Chemistry, or related sciences
Work EnvironmentLaboratories focused on protein isolation, purification, and analysisLaboratories conducting biochemical experiments, sample preparation, and analysis
Industry UsagePharmaceutical, biotech, academic researchResearch institutions, biotech companies, academic labs
Common Search/ComparisonResearch Protein PurificationResearch Biochemistry Technician

Research Protein Purification specialists focus specifically on isolating and purifying proteins for experiments, often requiring specialized techniques and equipment. Research Biochemistry Technicians perform broader biochemical tasks, including sample preparation and analysis. While both roles work in laboratory settings within similar industries, their core responsibilities and skill sets differ slightly, with protein purification being more specialized.

What are some common challenges faced during protein purification in a research setting, and how can they be addressed?

One common challenge in research protein purification is maintaining protein stability and activity throughout the process, as proteins can denature or degrade easily. Another issue is achieving sufficient yield and purity, especially when working with low-expression proteins or complex mixtures. Overcoming these challenges often involves optimizing buffer conditions, choosing the right purification methods (such as affinity, ion-exchange, or size-exclusion chromatography), and troubleshooting at each step. Collaborating closely with colleagues in molecular biology, biochemistry, and analytical teams is also essential for problem-solving and method development.

What is research protein purification?

Research protein purification is the process of isolating a specific protein from a complex mixture, such as cells or tissues, for study or use in experiments. This process involves several steps, including extraction, separation, and analysis, to obtain a highly pure and functional protein. Protein purification is crucial in biochemical and pharmaceutical research, as it enables scientists to study protein structure, function, and interactions. Techniques used include chromatography, electrophoresis, and centrifugation, among others. Mastery of protein purification methods is essential for producing proteins for drug development, diagnostics, and basic research.

What are the key skills and qualifications needed to thrive in Research Protein Purification, and why are they important?

To excel in Research Protein Purification, you need a solid background in biochemistry or molecular biology, hands-on laboratory experience, and a relevant degree such as a BSc, MSc, or PhD. Familiarity with chromatographic systems (e.g., FPLC, HPLC), protein characterization methods, and software for data analysis is typically required. Attention to detail, analytical thinking, and effective communication are crucial soft skills for troubleshooting and collaborating with research teams. These competencies ensure the reliable isolation and analysis of proteins, which are fundamental for advancing scientific research and therapeutic development.
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Research Protein Purification jobs near you
Scientist-Principal Scientist, Protein Design & Structure

Scientist-Principal Scientist, Protein Design & Structure

Superluminal Medicines, Inc.

Boston, MA

Other

Posted 3 days ago

Job description

Position Summary

We are seeking a highly innovative and experienced Scientist/Senior Scientist/Principal Scientist to lead GPCR protein engineering and production efforts. The successful candidate will be a subject matter expert (SME) in membrane protein biochemistry, responsible for developing and implementing strategies to express, purify, and characterize challenging G-protein coupled receptors (GPCRs) to support structural biology, biophysics, and drug discovery programs. This role involves hands-on laboratory work and scientific leadership. 

Key Responsibilities

  • Protein Engineering Strategy: Design, execute, and optimize constructs for GPCR expression.
  • Expression & Purification: Drive the development of high-throughput protein expression (mammalian/insect cells) and purification workflows, ensuring high-quality, homogeneous protein for assays and structural studies (Cryo-EM).
  • Cross-Functional Collaboration: Partner with pharmacology, structural biology, and medicinal chemistry teams to support drug discovery projects and advance programs from hit-to-lead and lead optimization.
  • Technical Leadership: Serve as a SME on GPCR protein sciences in internal and external project teams; evaluate and implement new technologies.
  • Scientific Documentation & Communication: Document experiments in ELN, present data at internal/external meetings, and publish research findings.

Required Qualifications

  • Ph.D. in Biochemistry, Molecular Biology, Biophysics, or a related field with 2+ years (Scientist), 5+ years (Senior Scientist), or 8+ years (Principal Scientist) of relevant experience; or a master's or bachelor's degree in a related field with commensurate industry experience. 
  • Deep knowledge of GPCR biology and membrane protein structure-function relationships.
  • Proven expertise in molecular biology (cloning, construct design, mutagenesis).
  • Hands-on experience in protein purification of GPCRs using FPLC (affinity, SEC).
  • Familiarity with protein stabilization techniques (e.g., antibody fragments, fusion partners, mutagenesis).
  • Excellent communication, interpersonal, and leadership skills.

Preferred Qualifications

  • Experience with structural biology methods (data collection and processing for Cryo-EM).
  • Experience in laboratory automation in protein sciences & purification.
  • Background in computational protein design tools (e.g., Rosetta, AI/ML-driven prediction).

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