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Protein Crystallography Jobs (NOW HIRING)

Artech Information System LLC

Bench Scientist

Cambridge, MA

$38.50 - $48.25/hr

We are seeking for a highly-motivated scientist who will provide support for protein crystallography by generating the material necessary to solve the x-ray crystal structures and by carrying out ...

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Protein Crystallography information

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How much do protein crystallography jobs pay per hour?

As of Aug 19, 2026, the average hourly pay for protein crystallography in the United States is $37.89, according to ZipRecruiter salary data. Most workers in this role earn between $25.00 and $47.60 per hour, depending on experience, location, and employer.

What is protein crystallography?

A Protein Crystallography job involves determining the 3D structures of proteins using X-ray crystallography or cryo-electron microscopy. Scientists in this role grow protein crystals, collect diffraction data, and analyze molecular structures to understand protein function. These insights are critical for drug design, enzyme engineering, and fundamental biological research. Positions are typically found in academia, pharmaceuticals, and biotechnology companies. Strong skills in structural biology, biochemistry, and computational modeling are often required.

What are the main challenges faced in a protein crystallography role, and how can they be addressed?

One of the primary challenges in Protein Crystallography is obtaining high-quality protein crystals, as this process often requires extensive optimization and troubleshooting. Additionally, interpreting diffraction data and solving complex protein structures can be time-consuming and may involve overcoming technical hurdles. Collaborating closely with colleagues in molecular biology, bioinformatics, and computational chemistry is essential for success. Staying persistent and adaptable, and seeking mentorship from experienced team members, can help navigate these challenges and lead to successful outcomes in structural biology projects.

What are the key skills and qualifications needed to thrive in protein crystallography, and why are they important?

To thrive in Protein Crystallography, you need expertise in molecular biology, protein purification, crystallization techniques, and structural biology, typically supported by an advanced degree in biochemistry or a related field. Familiarity with X-ray diffraction equipment, data analysis software (such as CCP4, Phenix, or Coot), and lab management systems is essential. Attention to detail, problem-solving abilities, and strong collaboration skills are key soft skills for effective research and teamwork. These competencies ensure accurate structural analysis, smooth laboratory operations, and valuable contributions to scientific discovery.

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Protein Crystallography jobs near you
Infographic showing various Protein Crystallography job openings in the United States as of August 2026, with employment types broken down into 82% Full Time, 15% Part Time, 2% Contract, and 1% Nights. Highlights an 90% Physical, 1% Hybrid, and 9% Remote job distribution, with an average salary of $78,821 per year, or $37.9 per hour.

Research Scientist I - Protein Sciences and Structural Biology

Broad Institute

Cambridge, MA • On-site

$88K - $124K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Re-posted 4 days ago

Job description

General information
Location
Cambridge, MA
Ref #
44535
Job Family
Research
Date published
08/12/2026
Time Type
Full time
Pay Range
$88,000.00/yr - $124,000.00/yr
Description & Requirements
Embedded within the Broad Institute, the Center for the Development of Therapeutics (CDoT) is a highly collaborative organization of professional drug discovery scientists. Our mission is to translate cutting edge biological insights originating from the Broad community into impactful drug discovery projects. We partner with faculty from MIT, Harvard, and the Harvard teaching hospitals together with industry partners in pharmaceutical, biotechnology and venture capital firms to validate druggable targets and identify leads. We combine our deep expertise in drug discovery with the knowledge and unique capabilities of the Broad Institute to explore drug discovery projects in a wide range of disease areas (including oncology, cardiovascular, psychiatry, infectious and rare diseases). We use systematic approaches in genomics, biology, high content imaging, chemistry, and machine learning coupled with the Broad's culture of creativity, risk taking, and open sharing, to successfully advance science and develop new treatments for patients.
We are seeking a passionate and highly motivated Research Scientist I to join CDoT's Protein Technologies team. The successful candidate will have a solid understanding of protein construct design, expression, purification, and quality assessment. Experience in structural biology is advantageous.
Principle Duties and Responsibilities:
  • Developing and executing strategies to clone and express recombinant proteins in a variety of expression systems
  • Purifying tagged or native proteins using standard purification (FPLC systems and column chromatography) and analytical techniques (SDS-PAGE, Western blot, light scattering, and protein LC/MS)
  • With training, produce high quality protein crystal structures and co-crystal structures, carrying out the process from crystallization screening through to structure refinement
  • Initiating and completing routine protein construct design and production in an independent and efficient manner
  • Demonstrating the ability to interpret experimental outcomes and proposing follow-up studies
  • Troubleshooting and solving scientific problems related to protein production independently
  • Operating and maintaining lab equipment independently, including protein purification systems like an AKTA pure
  • Investigating new technologies related to protein expression and purification
  • Documenting work and effectively presenting results in cross-functional project teams

Requirements:
  • Ph.D in Biophysics, Biochemistry, Molecular Biology, Structural Biology or related life science field with 0-2+ years of research experience in an industrial or academic setting
  • Expertise in recombinant protein purification using chromatography (affinity, ion exchange, and size exclusion)
  • Significant experience with cloning and expressing proteins using different vectors, tags, and various cell culture systems (mammalian, insect, bacterial, yeast)
  • Significant experience with protein characterization (analytical size exclusion chromatography, mass spectrometry, light scattering, western blot and biophysical binding studies)
  • Experience in protein crystallography and crystallographic data processing, model refinement, and structural analysis is a plus
  • Experience with biophysical characterization of proteins (ITC, DSC, SPR, NMR etc.) is a plus
  • A proven record of successful interaction with project team members, external customers or vendors

The successful candidate will be a results-focused, team-oriented, creative bench scientist able to excel in a fast-track environment. She or he must be self-motivated, detail-oriented and exhibit strong problem solving skills. In addition, the successful candidate should be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with project teams, peers, and management in identifying and achieving research goals.
The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law.
At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits.
The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations.
Should you need a reasonable accommodation to complete the application or interview process, please contact recruiting@broadinstitute.org for assistance.

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