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Protein Purification Scientist Jobs (NOW HIRING)

Amgen

Scientist - Protein Biochemist

Thousand Oaks, CA · On-site

Develop and optimize purification protocols and reagents, ensuring high protein purity, homogeneity ... The Scientist we seek is a highly motivated professional with these qualifications. Basic ...

TechData Service Company LLC

Be Seen First

Formulation Scientist

Alameda, CA · On-site

$40 - $60/hr

W2 Position Summary The Lead Discovery and Structural Biology Department within client is seeking a highly qualified Protein Expression & Purification Scientist (Contractor) with demonstrated ...

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How much do protein purification scientist jobs pay per hour?

As of Jul 30, 2026, the average hourly pay for protein purification scientist in the United States is $33.06, according to ZipRecruiter salary data. Most workers in this role earn between $21.63 and $40.87 per hour, depending on experience, location, and employer.

What does a Protein Purification Scientist do?

A Protein Purification Scientist is responsible for isolating and purifying proteins from biological samples for research or industrial applications. They use a variety of techniques such as chromatography, centrifugation, and filtration to obtain proteins in a highly pure and functional state. Their work is essential in fields like drug development, biotechnology, and academic research, where purified proteins are needed for experiments, therapeutic use, or structural studies.

What are some typical challenges faced by a Protein Purification Scientist and how are they addressed within the team?

Protein Purification Scientists often encounter challenges such as low protein yield, contamination, or protein instability during the purification process. These issues are usually addressed through careful optimization of protocols, frequent troubleshooting, and close collaboration with upstream and downstream teams (such as molecular biologists and analytical chemists). Regular team meetings and data sharing help ensure that any technical hurdles are resolved efficiently, and scientists are encouraged to stay updated with the latest purification technologies and methodologies. Support from experienced colleagues and access to well-equipped laboratories also play a key role in overcoming these challenges.

What are the key skills and qualifications needed to thrive as a Protein Purification Scientist, and why are they important?

To thrive as a Protein Purification Scientist, you need a strong background in biochemistry, molecular biology, and protein chemistry, typically supported by an advanced degree in a relevant field. Experience with chromatography systems (such as FPLC or HPLC), analytical tools (like SDS-PAGE and Western blot), and knowledge of GMP/GLP standards or relevant certifications are highly valuable. Excellent problem-solving, meticulous attention to detail, and effective teamwork and communication skills help scientists excel in this role. These skills are essential for ensuring the successful isolation and characterization of proteins, which supports research, drug development, and quality control in the biotechnology and pharmaceutical industries.

What Is the Job of a Protein Purification Scientist?

As a protein purification scientist, your job is to work in a laboratory and manufacture purified proteins according to a company's specifications. Your work involves a significant amount of observation for each batch of proteins you create. You analyze the product after it's made to verify the quality, find ways to use the protein in research and commercial products, and may help other scientists develop medicines. Employers expect you to remain familiar with the latest purification strategies for the mammalian cell culture process. Other aspects of this job involve troubleshooting production processes and training junior staff members.

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Protein Purification Scientist jobs near you
Infographic showing various Protein Purification Scientist job openings in the United States as of July 2026, with employment types broken down into 81% Full Time, 17% Part Time, 1% Contract, and 1% Nights. Highlights an 89% Physical, 1% Hybrid, and 10% Remote job distribution, with an average salary of $68,765 per year, or $33.1 per hour.

Protein Expression Scientist - Temp

System One

Alameda, CA • On-site

$50 - $55/hr

Contractor

Medical, Dental, Vision, Life, Retirement

Re-posted 13 days ago

Job description

Job Title: Protein Expression & Purification Scientist Location: Alameda, CA Type: 12 month contract Compensation: $50-55/hour depending on qualifications Contractor Work Model: Onsite Hours: 40 hours/week

Overview

We are seeking a Protein Expression & Purification Scientist to support drug discovery programs through the design, expression, purification, and characterization of recombinant proteins. This hands-on laboratory role requires expertise in molecular biology, protein expression systems, and chromatographic purification methods, with opportunities to contribute across multiple research initiatives in a fast-paced discovery environment.

Responsibilities

  • Design, clone, and optimize expression constructs using molecular biology techniques, including PCR, primer design, sequence verification, and recombinant cloning strategies.
  • Execute recombinant protein expression workflows using baculovirus expression vector systems (BEVS) in insect cells and E. coli expression platforms.
  • Generate, amplify, and optimize baculovirus stocks to support protein production objectives.
  • Perform high-throughput small-scale expression screening to evaluate constructs, expression conditions, and protein yield.
  • Purify recombinant proteins using affinity, ion exchange, and size-exclusion chromatography techniques.
  • Optimize expression, culture, and purification parameters to improve protein yield, purity, and overall quality.
  • Conduct analytical characterization using SDS-PAGE, Western blotting, SEC, and related protein analysis methods.
  • Document experimental procedures, results, and observations in accordance with laboratory documentation standards.
  • Analyze data, troubleshoot technical challenges, and recommend improvements to workflows and experimental strategies.
  • Communicate scientific findings and project updates effectively with cross-functional team members.

Requirements

Required Qualifications

  • Bachelor's degree in Biochemistry, Molecular Biology, Structural Biology, or a related scientific discipline with 3+ years of relevant industry experience; or Master's degree with 1+ year of relevant industry experience.
  • Strong expertise in molecular biology techniques, including cloning, vector design, construct optimization, and sequence verification.
  • Experience with PCR, primer design, restriction enzyme-based cloning, and recombination-based cloning methods.
  • Demonstrated experience expressing recombinant proteins in BEVS/insect cell systems and E. coli expression systems.
  • Experience with high-throughput small-scale protein expression screening.
  • Proficiency in protein purification using chromatographic techniques, including affinity, ion exchange, and size-exclusion chromatography.
  • Experience performing protein analytical characterization using SDS-PAGE, Western blotting, SEC, and related techniques.
  • Strong analytical, troubleshooting, and problem-solving skills.
  • Ability to independently manage experiments while collaborating effectively within multidisciplinary teams.
  • Strong organizational, documentation, and scientific communication skills.

Preferred Qualifications

  • Experience with biophysical characterization techniques such as LC-MS, SPR, MST, SEC-MALS, nanoDSF, or mass photometry.
  • Experience with protein purification method development and process optimization.
  • Familiarity with electronic laboratory notebooks, including Benchling.
  • Experience supporting protein production activities within a drug discovery or biopharmaceutical research environment.

Benefits

System One, and its subsidiaries including Joulé, ALTA IT Services, and Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.

System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.

Ref: #568-Clinical