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Bioconjugation Jobs (NOW HIRING)

Manifold Bio

Scientist, Bioconjugation

Boston, MA

$118K - $138K/yr

You will be responsible for designing and executing bioconjugation strategies for protein-oligonucleotide conjugates, as well as bioconjugated fluorophores, tags, and peptides. In addition to ...

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Bioconjugation information

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$30

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How much do bioconjugation jobs pay per hour?

As of Jul 21, 2026, the average hourly pay for bioconjugation in the United States is $61.42, according to ZipRecruiter salary data. Most workers in this role earn between $42.55 and $73.80 per hour, depending on experience, location, and employer.

What is the difference between Bioconjugation vs Protein Conjugation?

AspectBioconjugationProtein Conjugation
Required CredentialsBiochemistry, Molecular Biology certificationsBiochemistry, Molecular Biology certifications
Work EnvironmentLaboratories, biotech companiesLaboratories, biotech companies
Industry UsageDrug development, diagnostics, researchDrug development, diagnostics, research
Common Search IntentUnderstanding bioconjugation techniquesUnderstanding protein conjugation methods

Bioconjugation involves attaching biomolecules like drugs, antibodies, or peptides to other molecules for various applications. Protein conjugation specifically focuses on linking proteins to other molecules, often as part of bioconjugation processes. While both roles require similar skills and work environments, bioconjugation covers a broader range of biomolecules, whereas protein conjugation is specialized in working with proteins. Understanding these differences helps professionals and employers target the right expertise for biotech projects.

What is bioconjugation?

Bioconjugation is the process of chemically linking two molecules, at least one of which is a biological molecule such as a protein, peptide, or antibody. This technique is commonly used to attach drugs, fluorescent dyes, or other markers to biomolecules for research, diagnostic, or therapeutic purposes. Bioconjugation plays a crucial role in developing targeted drug delivery systems, biosensors, and imaging agents. The process requires careful selection of conjugation chemistries to preserve the function of the biomolecules involved.

What are the key skills and qualifications needed to thrive in a bioconjugation scientist role, and why are they important?

To thrive as a bioconjugation scientist, you need a solid background in chemistry or biochemistry, experience with protein modification techniques, and typically a relevant advanced degree. Familiarity with analytical tools like HPLC, mass spectrometry, and knowledge of Good Laboratory Practice (GLP) or GMP guidelines is common, along with experience using laboratory information management systems (LIMS). Strong problem-solving skills, attention to detail, and effective communication are crucial soft skills for collaborating across research teams and troubleshooting experimental challenges. These competencies ensure the efficient development of high-quality bioconjugates for applications in therapeutics, diagnostics, or research.

What are some common challenges faced by professionals working in bioconjugation, and how can they be addressed?

One common challenge in bioconjugation roles is ensuring the specificity and stability of the conjugates produced, as improper coupling can affect the efficacy and safety of the final product. Additionally, troubleshooting complex reactions and optimizing protocols for scale-up requires strong problem-solving skills and familiarity with analytical techniques. Effective collaboration with cross-functional teams such as analytical chemistry, process development, and quality assurance is vital to overcoming these obstacles and ensuring project success. Staying updated with the latest advances in conjugation chemistries and regulatory requirements also helps professionals adapt to the evolving landscape.
More about Bioconjugation jobs
What cities are hiring for Bioconjugation jobs? Cities with the most Bioconjugation job openings:
What states have the most Bioconjugation jobs? States with the most job openings for Bioconjugation jobs include:
What job categories do people searching Bioconjugation jobs look for? The top searched job categories for Bioconjugation jobs are:
Bioconjugation jobs near you
Infographic showing various Bioconjugation job openings in the United States as of July 2026, with employment types broken down into 71% Full Time, and 29% Contract. Highlights an 100% In-person job distribution, with an average salary of $127,745 per year, or $61.4 per hour.
Scientist, Bioconjugation

Scientist, Bioconjugation

Manifold Bio

Boston, MA

$118K - $138K/yr

Other

Medical, Dental, Vision, Retirement, PTO

Posted 14 days ago

Job description

Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.

Position

Manifold Bio is seeking a scientist experienced in protein chemistry, oligonucleotide chemistry, and bioconjugation. You will be responsible for designing and executing bioconjugation strategies for protein-oligonucleotide conjugates, as well as bioconjugated fluorophores, tags, and peptides. In addition to performing, optimizing, and troubleshooting bioconjugation in the lab, you will oversee contract research organizations executing specialized or large-scale bioconjugation projects. You will consistently execute core bioconjugation protocols, proactively contribute to workflow optimization, and bring your excitement for rigorous science and troubleshooting to our growing cross-functional team. You will join a team with deep experience in protein chemistry, RNA biology, and biology, and work closely with a highly interdisciplinary team of creative experimental and computational scientists to advance our tissue-targeted oligomedicines pipeline.

Responsibilities

  • Design, execute, and troubleshoot bioconjugation reactions for protein-oligonucleotide conjugates and other bioconjugated fluorophores, tags, and peptides
  • Purify and characterize bioconjugated products using standard biochemical techniques
  • Build and maintain a parallelized, efficient workflow to support in vivo target engagement evaluation of multiple new candidate tissue-targeting shuttles using tool siRNA payloads
  • Oversee contract research organizations (CROs) performing specialized or large-scale bioconjugation projects
  • Proactively identify and drive optimization of existing bioconjugation and analytical workflows
  • Maintain accurate, detailed experimental records and contribute to scientific discussions and experimental design

Required Qualifications

  • PhD in Biochemistry, Chemistry, Molecular Biology, or a related scientific field
  • Minimum of 3+ years of hands-on wet-lab experience in protein production, purification, and biochemistry
  • Proficiency in basic biochemical techniques (e.g., protein quantification, gel electrophoresis, chromatography)
  • Proven ability to troubleshoot biochemical assays and optimize experimental protocols
  • Experience with bioconjugation chemistry principles and methodologies (e.g., cysteine-based, lysine-based, and/or enzymatic conjugation strategies)
  • Familiarity with oligonucleotide chemistry and handling

Preferred Qualifications

  • Experience with high-throughput screening or automation
  • Familiarity with analytical techniques for biomolecule characterization (e.g., mass spectrometry, DLS, BLI, SPR)
  • Experience establishing and troubleshooting enzymatic assays
  • Demonstrated leadership or mentorship of junior scientists
  • Strong presentation skills and design sensibility

Why you might be a good fit

  • You get energy from solving a critical-path bottleneck and building the workflow that unblocks the rest of the team
  • You take rigor seriously and want your bioconjugated constructs to be reproducible at scale
  • You're comfortable managing external partners and holding CRO-generated work to the same bar as your own
  • You're scrappy, iterate quickly, and take ownership of projects through to resolution
  • You communicate clearly, document rigorously, and enjoy working across a highly interdisciplinary team

If you're excited to use unique protein technologies to shape an innovative drug development strategy, build meaningful industry partnerships, and contribute directly to our mission of advancing breakthrough treatments, please apply!

Base Salary Range: $118,000 - $138,000

This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate's experience, interview performance, and expected impact.

This role is eligible for:

  • Annual performance-based target bonus
  • Stock options
  • Comprehensive medical, dental, and vision coverage
  • 401(k) plan
  • Flexible paid time off and holidays
  • Perks including on-site gym, onsite lunch, and commuter support

Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.

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