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Bioconjugation Scientist

Indianapolis, IN · On-site

... bioconjugation or purification techniques * Demonstrated proficiency in a laboratory setting * Works effectively with others in a team setting * Strong hands-on experimental skills and attention to ...

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Bioconjugation information

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How much do bioconjugation jobs pay per hour?

As of Jul 21, 2026, the average hourly pay for bioconjugation in the United States is $61.42, according to ZipRecruiter salary data. Most workers in this role earn between $42.55 and $73.80 per hour, depending on experience, location, and employer.

What is the difference between Bioconjugation vs Protein Conjugation?

AspectBioconjugationProtein Conjugation
Required CredentialsBiochemistry, Molecular Biology certificationsBiochemistry, Molecular Biology certifications
Work EnvironmentLaboratories, biotech companiesLaboratories, biotech companies
Industry UsageDrug development, diagnostics, researchDrug development, diagnostics, research
Common Search IntentUnderstanding bioconjugation techniquesUnderstanding protein conjugation methods

Bioconjugation involves attaching biomolecules like drugs, antibodies, or peptides to other molecules for various applications. Protein conjugation specifically focuses on linking proteins to other molecules, often as part of bioconjugation processes. While both roles require similar skills and work environments, bioconjugation covers a broader range of biomolecules, whereas protein conjugation is specialized in working with proteins. Understanding these differences helps professionals and employers target the right expertise for biotech projects.

What is bioconjugation?

Bioconjugation is the process of chemically linking two molecules, at least one of which is a biological molecule such as a protein, peptide, or antibody. This technique is commonly used to attach drugs, fluorescent dyes, or other markers to biomolecules for research, diagnostic, or therapeutic purposes. Bioconjugation plays a crucial role in developing targeted drug delivery systems, biosensors, and imaging agents. The process requires careful selection of conjugation chemistries to preserve the function of the biomolecules involved.

What are the key skills and qualifications needed to thrive in a bioconjugation scientist role, and why are they important?

To thrive as a bioconjugation scientist, you need a solid background in chemistry or biochemistry, experience with protein modification techniques, and typically a relevant advanced degree. Familiarity with analytical tools like HPLC, mass spectrometry, and knowledge of Good Laboratory Practice (GLP) or GMP guidelines is common, along with experience using laboratory information management systems (LIMS). Strong problem-solving skills, attention to detail, and effective communication are crucial soft skills for collaborating across research teams and troubleshooting experimental challenges. These competencies ensure the efficient development of high-quality bioconjugates for applications in therapeutics, diagnostics, or research.

What are some common challenges faced by professionals working in bioconjugation, and how can they be addressed?

One common challenge in bioconjugation roles is ensuring the specificity and stability of the conjugates produced, as improper coupling can affect the efficacy and safety of the final product. Additionally, troubleshooting complex reactions and optimizing protocols for scale-up requires strong problem-solving skills and familiarity with analytical techniques. Effective collaboration with cross-functional teams such as analytical chemistry, process development, and quality assurance is vital to overcoming these obstacles and ensuring project success. Staying updated with the latest advances in conjugation chemistries and regulatory requirements also helps professionals adapt to the evolving landscape.
More about Bioconjugation jobs
What cities are hiring for Bioconjugation jobs? Cities with the most Bioconjugation job openings:
What states have the most Bioconjugation jobs? States with the most job openings for Bioconjugation jobs include:
What job categories do people searching Bioconjugation jobs look for? The top searched job categories for Bioconjugation jobs are:
Bioconjugation jobs near you
Infographic showing various Bioconjugation job openings in the United States as of July 2026, with employment types broken down into 71% Full Time, and 29% Contract. Highlights an 100% In-person job distribution, with an average salary of $127,745 per year, or $61.4 per hour.
Senior Scientist, Process Development - Bioconjugation

Senior Scientist, Process Development - Bioconjugation

Dyne Therapeutics

Waltham, MA • On-site

$147K - $180K/yr

Full-time

Re-posted 21 days ago

Job description

Company Overview:
Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook.
Role Summary:
The position is responsible for process development, technology transfer, and management of external CDMO activities to ensure development of robust and reliable GMP manufacturing processes for antibody oligonucleotide conjugates and intermediates. The Senior Scientist will represent CMC Process Sciences as a technical leader and provide guidance to internal process development staff and external vendors on oligonucleotide conjugate development and manufacturing activities from pre-clinical to GMP production for clinical evaluation (Phase 1-3). This includes active oversight of process establishment, process development, scale-down model verification, and process characterization. This person will also have direct oversight of CDMO technology transfer and process development operations.
This position works closely with key stakeholders including Platform Research, External Manufacturing, Regulatory Affairs, and Project Management to meet the needs of Dyne's complex clinical supply chain, supporting our preclinical and clinical programs.
This role is based in Waltham, MA without the possibility of being a remote role. Physical presence onsite is expected on 4-5 days/week.
Primary Responsibilities Include:
  • Responsible for drug substance bioconjugation including process development, tech transfer, scale-up, and process characterization of oligonucleotide conjugates.
  • Lead internal CMC Process Development activities via hands-on contribution in the laboratory.
  • Work with CDMOs to manage external process development, optimization, and tech transfer of new programs in a stage appropriate manner to ensure key milestones and products are delivered on schedule.
  • Partner with Research to support bioconjugation development activities and enhance the tech transfer process to external manufacturing partners.
  • Represent bioconjugation Drug Substance process as a technical leader in internal cross-functional CMC teams.
  • Establish clear expectations and priorities, set objectives, and effectively apply resources to deliver on program goals.
  • Select, qualify and manage external contract development and manufacturing organizations.
  • Drive continuous improvement opportunities, adapt to and solve challenges and lead the timely resolution of issues.
  • Evaluate and implement emerging technologies/applications to improve conjugation processes and optimize purification methods.
  • Partner with internal cross functional teams and serve as the liaison to define suitable, compliant, and defendable CMC strategies.
  • Prepare technical source documents, publications, and oral presentations.
  • Prepare and review relevant CMC and product related sections and documentation for global regulatory submission.
  • Review and approve documents related to development and cGMP operations, including Tech Transfer, Process Characterization, Master Batch Records (MBRs) and Campaign Summary Reports.

Education and Skills Requirements:
  • PhD or equivalent experience in a scientific discipline and a minimum of 5+ years related experience working with bioconjugates including a deep understanding of conjugation chemistries, preparative chromatography, and TFF.
  • Experience in biopharmaceutical CMC management and/or Research & Development preferably in a clinical-stage biotechnology company.
  • Familiarity working with oligonucleotides including but not limited to morpholino oligonucleotides, antisense oligonucleotides, and siRNA is desired.
  • Hands on experience with analytical techniques for characterization of conjugates including HPLC/UPLC, SEC, SDS-PAGE, ion exchange chromatography, and UV/vis.
  • Experience with oversight of external contract development and manufacturing (CDMO)
  • Ability to problem solve emerging issues related to drug substance development.
  • A strong understanding of biologics and small molecule manufacturing, analytical development, quality control, quality assurance, and regulatory functions.
  • Self-directed individual who is able to work effectively with limited direction in a complex, fast-paced environment.
  • Excellent interpersonal, organizational, negotiation, and communication skills; a team member that can work collaboratively with colleagues across functions.

#LI-Onsite
MA Pay Range
$147,000-$180,000 USD
The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills.
The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.
Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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