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LCMS Scientist

Columbia, MO

Senior / Principal LC-MS Scientist Columbia, Missouri (on-site) Relocation assistance available We are searching for a Senior / Principal LC-MS Scientist to join a growing bioanalytical team in ...

Parexel

Validate, and utilize LC-MS to support sample analysis. * Ensure GLP compliance. * Communicate results effectively to team members and supervising principal investigators. Qualifications * Scientist ...

Planet Pharma

Scientist - LCMS

Columbia, MO · On-site

Scientist - LC-MS Location: Columbia, MO Job Type: Full-Time Openings: 2 About the Rol eAs an LC-MS Scientist, you will support nonclinical bioanalytical studies through method development ...

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Agilent

LC/MS Applications Scientist

Santa Clara, CA · On-site

$156K - $244K/yr

The LC/MS application scientist team have been at the forefront of developing customer centric differentiated applications and workflow solutions in the market segments we serve. We are seeking a ...

Agilent

LC/MS Applications Scientist

Santa Clara, CA

$156K - $244K/yr

The LC/MS application scientist team have been at the forefront of developing customer centric differentiated applications and workflow solutions in the market segments we serve. We are seeking a ...

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Lc Ms Scientist information

What are some common challenges faced by LC-MS Scientists when developing new analytical methods?

LC-MS Scientists often encounter challenges such as matrix effects, where components in the sample interfere with analyte detection, and the need to balance sensitivity with specificity. Method development also requires careful optimization of sample preparation, chromatographic conditions, and mass spectrometer settings to achieve accurate, reliable results. Collaboration with colleagues in sample preparation, data analysis, and quality assurance is key to troubleshooting and refining methods. Staying current with advancements in instrumentation and software can also help overcome technical challenges and improve workflow efficiency.

What are LC-MS scientists?

LC-MS scientists are analytical chemists who specialize in using liquid chromatography-mass spectrometry (LC-MS) techniques to identify, quantify, and analyze chemical compounds in various samples. They play a critical role in fields such as pharmaceuticals, environmental science, food safety, and biotechnology by preparing samples, operating LC-MS instruments, and interpreting complex data. Their work helps ensure product safety, compliance with regulations, and advances in research and development.

What are the key skills and qualifications needed to thrive as an LC-MS Scientist, and why are they important?

To excel as an LC-MS Scientist, a strong background in analytical chemistry, experience with liquid chromatography-mass spectrometry (LC-MS), and at least a bachelor's or master's degree in a relevant scientific field are essential. Familiarity with data analysis software (such as MassLynx or Xcalibur), instrument calibration, and method development is typically required. Attention to detail, problem-solving skills, and effective communication help scientists interpret data accurately and collaborate across multidisciplinary teams. These skills are crucial for ensuring high-quality analytical results and supporting research or regulatory compliance in laboratory settings.
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Infographic showing various Lc Ms Scientist job openings in the United States as of June 2026, with employment types broken down into 93% Full Time, and 7% Part Time. Highlights an 95% Physical, 1% Hybrid, and 4% Remote job distribution.
LC-MS/MS Scientist/Bioanalytical Principal Investigator

LC-MS/MS Scientist/Bioanalytical Principal Investigator

Altasciences

Columbia, MO • On-site

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 27 days ago

Altasciences rating

7.6

Company rating: 7.6 out of 10

Based on 17 frontline employees who took The Breakroom Quiz

53rd of 103 rated laboratories

Job description

Your New Company!
At Altasciences we all move in unison to assist and work in the discovery, development, and manufacturing of new drug therapies to get them faster to people who need them. No matter your role, we all play an important part and you will have a significant impact on the health and well-being of people across the globe. By living our values of Employee Development, Customer Focus, Quality and Excellence, Respect and Integrity, we look to foster a passionate and collaborative work environment and we are looking for talented and enthusiastic people, like you, to join our growing team! Whether you're a recent college graduate or seeking your next career opportunity, it's time to discover your future at Altasciences.
We are better together and together We Are Altasciences.
About The Role
As Scientist/Bioanalytical Principal Investigator in the LC-MS/MS group at Altasciences, you will be responsible for the conduct of method validation and sample analysis related to assigned nonclinical bioanalytical studies utilizing LC-MS/MS instrumentation. You will also be responsible for direct interaction with clients, report writing, and adherence to regulatory guidelines. You will collaborate with other scientists, analysts, and departments in a team-oriented environment. You will possess knowledge and experience in a Good Laboratory Practice (GLP) environment and be able to adhere to GLP guidelines and practices.
What You'll Do Here
  • Serve as Principal Investigator and contributing scientist for LC-MS/MS analysis in support of regulated nonclinical studies.
  • Maintain open and direct communication and attend recurring calls with clients.
  • Prepare all necessary driving documents for in-lab analysis.
  • Complete and deliver scientific reports to clients on time.
  • Collaborate with internal regulatory departments to ensure quality and compliance oversight on GLP studies.
  • Plan, oversee and guide the timely completion of laboratory work in support of Method Validation and Sample Analysis for nonclinical studies using LC-MS/MS
  • Maintain all documentation in support of Method Validation and Sample Analysis for assigned studies.
  • Maintain and update facility records related to the laboratory and its analyses.
  • Review laboratory records, procedures and study data for completeness and accuracy.
  • Document deviations to laboratory procedures and study protocols and unforeseen circumstances in a timely manner and provide input for corrective actions.
  • Assist in calibration, optimization, maintenance, and collection of data from analytical instruments.
  • Follow Alta's Standard Operating Procedures (SOPs), ensure compliance with regulatory, FDA, GLP, ALCOA++, USDA, and AAALAC guidelines, in the conduct of assigned studies.
  • Use your knowledge and experience to mentor, train, and develop more junior team members.Use your experience to improve and enhance processes and laboratory efficiency.

What You'll Need to Succeed
  • Associates/Bachelor's degree in Chemistry/Immunology/Biology or equivalent in discipline
  • Minimum of 5 years experience as a bioanalytical scientist in a CRO performing or overseeing regulated studies
  • Minimum 5 years experience with LC-MS instrumentation and software.
  • Experience in a Good Laboratory Practices (GLP) and CRO environment.
  • Ability to handle multiple projects, prioritize work, and meet deadlines.

Preferred Requirements
  • Master's degree or PhD in scientific related discipline.
  • Experience with Shimadzu and SCIEX instrumentation.
  • Experience with Watson.

What We Offer
Altasciences offers a wide variety of benefits to help our employees live healthy and fulfilling lives both at and outside of work.
Altasciences' Benefits Package Includes:
  • Health/Dental/Vision Insurance Plans
  • 401(k)/RRSP with Employer Match
  • Paid Vacation and Holidays
  • Paid Sick and Bereavement Leave
  • Employee Assistance & Telehealth Programs

Altasciences' Incentive Programs Include:
  • Training & Development Programs
  • Employee Referral Bonus Program
  • Annual Performance Review

#LI-TA1
MOVING IN UNISON TO DELIVER A BIG IMPACT WITH A PERSONAL TOUCH
Altasciences is an equal opportunity employer committed to diversity and inclusion. Our goal is to attract, develop and retain highly talented employees from diverse backgrounds, allowing us to benefit from a wide variety of experiences and perspectives. All qualified applicants will receive consideration for employment without regard to age, race, color, religion, creed, sex, sexual orientation, gender identity, national origin, disability or any other protected grounds under applicable legislation. Reasonable accommodations for persons with disabilities during the recruitment process are available upon request. Join us at Altasciences!

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