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Principal Statistical Programmer Jobs in Raleigh, NC

Guidehouse

Bioinformatics Scientist

Durham, NC · On-site

... principal component, meta-analysis, and related statistical analyses. * Interpret genomic and ... programming, laboratory, and interdisciplinary meetings. * Prepare reports, protocols, technical ...

Guidehouse

Bioinformatics Scientist

Durham, NC · On-site +1

... principal component, meta-analysis, and related statistical analyses. * Interpret genomic and ... programming, laboratory, and interdisciplinary meetings. * Prepare reports, protocols, technical ...

Blythe Construction Inc

Project Engineer - Asphalt

Raleigh, NC · On-site

$61K - $78K/yr

Principals ONLY - NO Recruiters Description Who We Are Vinci Construction USA is a full-service ... The Project Engineer will interface with clients, attend meetings, and provide statistical reports ...

NC SECU

Financial Data Analyst II

Raleigh, NC · On-site

Programming for Data Analytics (e.g., Python or R) * Business Statistics * Database Management (e.g ... Financial Accounting Principals * Managerial Accounting Techniques * Predictive Analytics

NCSU

Research Assistant

Raleigh, NC

$18.75 - $25.75/hr

Working in collaboration with the Principal Investigator (PI), this position independently ... The position supports externally funded research and Extension programming by coordinating field ...

Duke University

Associate in Research

Durham, NC

In this role, you will work closely with the Principal Investigator Dr. Wenpin Hou and her research ... Strong programming skills. * Experience with machine learning frameworks such as PyTorch or ...

Duke University

Associate in Research

Durham, NC · On-site

In this role, you will work closely with the Principal Investigator Dr. Wenpin Hou and her research ... Strong programming skills. * Experience with machine learning frameworks such as PyTorch or ...

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All JobsPrincipal Statistical Programmer JobsPrincipal Statistical Programmer Jobs in Raleigh, NC

Principal Statistical Programmer information

See Raleigh, NC salary details

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How much do principal statistical programmer jobs pay per hour?

As of Aug 27, 2026, the average hourly pay for principal statistical programmer in Raleigh, NC is $82.19, according to ZipRecruiter salary data. Most workers in this role earn between $70.82 and $94.86 per hour, depending on experience, location, and employer.

What is a principal statistical programmer?

A Principal Statistical Programmer is a senior-level professional responsible for developing, validating, and maintaining statistical programs used in clinical trials and regulatory submissions. They ensure data accuracy, adherence to industry standards (such as CDISC), and compliance with regulatory requirements. They collaborate with statisticians, data managers, and clinical teams to analyze and report trial results. Additionally, they may mentor junior programmers and contribute to process improvements in statistical programming workflows.

What are the typical daily responsibilities of a principal statistical programmer in a clinical research setting?

As a Principal Statistical Programmer, your daily responsibilities often include developing, validating, and maintaining complex statistical programs to support clinical trial data analysis and regulatory submissions. You may lead programming teams, mentor junior staff, and act as a technical expert on study projects, collaborating closely with statisticians, data managers, and clinical teams. The role frequently involves reviewing statistical analysis plans (SAPs), generating data listings and summary tables, and ensuring adherence to industry standards such as CDISC. Effective communication and time management are key, as you’ll often work on multiple projects simultaneously, balancing deliverables and troubleshooting technical challenges. This position offers diverse, impactful work where your expertise significantly contributes to the integrity and success of clinical research programs.

What are the key skills and qualifications needed to thrive in the principal statistical programmer position, and why are they important?

To thrive as a Principal Statistical Programmer, you need advanced expertise in statistical programming (typically with SAS or R), a strong understanding of clinical trial data, and a degree in a relevant field such as statistics, mathematics, or computer science. Familiarity with CDISC standards (SDTM, ADaM), regulatory submission requirements, and project management tools is highly valued, and certifications like SAS Certified Advanced Programmer can be advantageous. Leadership, problem-solving, attention to detail, and excellent communication skills are important for managing complex projects and collaborating across multidisciplinary teams. These skills collectively ensure accuracy, regulatory compliance, and successful delivery of statistical programming support within clinical research environments.

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Principal Statistical Programmer jobs near you
Infographic showing various Principal Statistical Programmer job openings in Raleigh, NC as of August 2026, with employment types broken down into 87% Full Time, 10% Part Time, 1% Temporary, and 2% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $170,964 per year, or $82.2 per hour.

Bioinformatics Scientist

Guidehouse

Durham, NC • On-site

Full-time

Medical, Dental, Vision, Life, Retirement

This job post has expired today. Applications are no longer accepted.

Guidehouse rating

8.0

Company rating: 8.0 out of 10

Based on 28 frontline employees who took The Breakroom Quiz

35th of 72 rated business consultants

Job description

Job Family:
Scientist
Travel Required:
None
Clearance Required:
Ability to Obtain Public Trust
What You Will Do:
We are looking for a Bioinformatics Scientist to support the operational objectives of the National Institute of Environmental Health Sciences (NIEHS) through advanced genomic data analysis, bioinformatics programming, and computational biology support. This position is a full-time position located in Research Triangle Park, NC and is telework eligible.
Analyze NGS, GWAS, genomic, biological, epidemiology, and population-based datasets, including ChIP-Seq, RNA-Seq, miRNA-Seq, SNP/structural variation discovery, imputation, stratification, haplotype, pathway, principal component, meta-analysis, and related statistical analyses.
  • Interpret genomic and targeted population study data, associated metadata, gene expression, exon, tiling, promoter, microarray, and multi-platform results to extract biologically meaningful insights.
  • Develop, implement, deploy, and maintain bioinformatics workflows, custom programs, utility scripts, macros, algorithms, analytical tools, and computational processes supporting experimental design, quality analysis, genome/metagenome integration, and biological discovery.
  • Use commercial software, freeware, custom-developed solutions, and high-performance computing environments to support scientific objectives, maintain workstations, and identify relevant analytical software solutions.
  • Collaborate with biologists, statisticians, bioinformaticians, investigators, and research teams to design analytical models, support data collection and experimental activities, and participate in scientific programming, laboratory, and interdisciplinary meetings.
  • Prepare reports, protocols, technical documentation, publication-quality graphics, and deliverables supporting NGS analyses, GWAS studies, statistical analyses, workflow development, publications, training activities, and scientific presentations.
  • Present findings to investigators, bioinformatics teams, study groups, and external audiences, and develop and deliver bioinformatics training materials, presentations, tutorials, and short-course instruction.

What You Will Need:
  • Master's degree in Bioinformatics, Biostatistics, Computational Biology, Biological Sciences, Mathematics, Computer Science, Environmental Science, Microbiology, Molecular Biology, or related scientific discipline.
  • Minimum of FIVE (5) years of experience in bioinformatics, computational biology, biostatistics, genomics, or a related field.
  • Hands-on background analyzing next-generation sequencing data and genomic datasets.
  • Working knowledge of Genome-Wide Association Studies (GWAS).
  • Background performing bulk RNA sequencing analysis.
  • Skilled in conducting microbiome, phylogenetic, multi-omics, microarray, and cluster analyses.
  • Ability to work with large and complex biological datasets.
  • Proven ability to develop bioinformatics pipelines and analytical workflows.
  • Proficiency with R, Python, MATLAB, Perl, Shell scripting, Unix/Linux environments, and Java.
  • Demonstrated ability to collaborate with multidisciplinary scientific teams.
  • Ability to prepare technical reports, scientific documentation, and publication-quality visualizations.
  • Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.

What Would Be Nice To Have:
  • Ph.D. in Bioinformatics, Biostatistics, Computational Biology, Biological Sciences, or a related scientific discipline.
  • Background supporting federal biomedical or environmental health research programs.
  • Strong written and verbal communication skills, including presentation experience.
  • Ability to develop custom bioinformatics applications and advanced computational algorithms.
  • Familiarity supporting high-performance computing environments.
  • Ability to provide bioinformatics training, mentoring, and instructional support.
  • Demonstrated contributions to scientific manuscripts and peer-reviewed publications.
  • Collaboration across interdisciplinary genomic, epidemiologic, and population-based research programs.

What We Offer:
Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.
Benefits include:
  • Medical, Rx, Dental & Vision Insurance
  • Personal and Family Sick Time & Company Paid Holidays
  • Parental Leave
  • 401(k) Retirement Plan
  • Group Term Life and Travel Assistance
  • Voluntary Life and AD&D Insurance
  • Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
  • Transit and Parking Commuter Benefits
  • Short-Term & Long-Term Disability
  • Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
  • Employee Referral Program
  • Corporate Sponsored Events & Community Outreach
  • Care.com annual membership
  • Employee Assistance Program
  • Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
  • Position may be eligible for a discretionary variable incentive bonus

About Guidehouse
Guidehouse is an Equal Opportunity Employer-Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.
Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.
If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at RecruitingAccommodation@guidehouse.com. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.
All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @guidehouse.com or guidehouse@myworkday.com. Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse. Note that Guidehouse will never charge a fee or require a money transfer at any stage of the recruitment process and does not collect fees from educational institutions for participation in a recruitment event. Never provide your banking information to a third party purporting to need that information to proceed in the hiring process.
If any person or organization demands money related to a job opportunity with Guidehouse, please report the matter to Guidehouse's Ethics Hotline. If you want to check the validity of correspondence you have received, please contact recruiting@guidehouse.com. Guidehouse is not responsible for losses incurred (monetary or otherwise) from an applicant's dealings with unauthorized third parties.
Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.

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