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Principal Statistical Programmer Jobs in Raleigh, NC

We are looking for a Principal Data Scientist I to join our Data Science / Embedded AI Innovation ... Bachelor's degree in Computer Science, Data Science, Statistics, Mathematics, Engineering ...

We are looking for a Principal Data Scientist I to join our Data Science / Embedded AI Innovation ... Bachelor's degree in Computer Science, Data Science, Statistics, Mathematics, Engineering ...

New

LexisNexis is seeking a Principal Data Scientist I to join their Data Science / Embedded AI ... Statistics, Mathematics, Engineering, Information Systems, Software Engineering, or a related ...

Principal Responsibilities • Drive supplier quality performance across commodities, PFGs, and ... statistical techniques to support quality and process improvement • Proven experience in supplier ...

Principal Responsibilities Drive supplier quality performance across commodities, PFGs, and ... applying statistical techniques to support quality and process improvement Proven experience in ...

Project Engineer - Asphalt

Raleigh, NC · On-site

$61K - $78.20K/yr

**Principals ONLY - NO Recruiters** Description Who We Are Vinci Construction USA is a full-service ... The Project Engineer will interface with clients, attend meetings, and provide statistical reports ...

Project Engineer - Asphalt

Raleigh, NC · On-site

$61K - $78.20K/yr

Principals ONLY - NO Recruiters Description Who We Are Vinci Construction USA is a full-service ... The Project Engineer will interface with clients, attend meetings, and provide statistical reports ...

... Engineering, or equivalent education and related training 2. Exhibit understanding of statistical ... principal components; working knowledge of calculus/differential equations, with understanding of ...

Principal Responsibilities Work as a Subject Matter Expert in many aspects of medical packaging ... and statistical analysis, assist in implementation with appropriate controls and metrics. • ...

Principal Responsibilities Work as a Subject Matter Expert in many aspects of medical packaging ... DOE and statistical analysis, assist in implementation with appropriate controls and metrics.

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Principal Statistical Programmer information

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$54

$82

$113

How much do principal statistical programmer jobs pay per hour?

As of May 29, 2026, the average hourly pay for principal statistical programmer in Raleigh, NC is $82.20, according to ZipRecruiter salary data. Most workers in this role earn between $70.82 and $94.86 per hour, depending on experience, location, and employer.

What is a Principal Statistical Programmer job?

A Principal Statistical Programmer is a senior-level professional responsible for developing, validating, and maintaining statistical programs used in clinical trials and regulatory submissions. They ensure data accuracy, adherence to industry standards (such as CDISC), and compliance with regulatory requirements. They collaborate with statisticians, data managers, and clinical teams to analyze and report trial results. Additionally, they may mentor junior programmers and contribute to process improvements in statistical programming workflows.

What are the key skills and qualifications needed to thrive in the Principal Statistical Programmer position, and why are they important?

To thrive as a Principal Statistical Programmer, you need advanced expertise in statistical programming (typically with SAS or R), a strong understanding of clinical trial data, and a degree in a relevant field such as statistics, mathematics, or computer science. Familiarity with CDISC standards (SDTM, ADaM), regulatory submission requirements, and project management tools is highly valued, and certifications like SAS Certified Advanced Programmer can be advantageous. Leadership, problem-solving, attention to detail, and excellent communication skills are important for managing complex projects and collaborating across multidisciplinary teams. These skills collectively ensure accuracy, regulatory compliance, and successful delivery of statistical programming support within clinical research environments.

What are the typical daily responsibilities of a Principal Statistical Programmer in a clinical research setting?

As a Principal Statistical Programmer, your daily responsibilities often include developing, validating, and maintaining complex statistical programs to support clinical trial data analysis and regulatory submissions. You may lead programming teams, mentor junior staff, and act as a technical expert on study projects, collaborating closely with statisticians, data managers, and clinical teams. The role frequently involves reviewing statistical analysis plans (SAPs), generating data listings and summary tables, and ensuring adherence to industry standards such as CDISC. Effective communication and time management are key, as you’ll often work on multiple projects simultaneously, balancing deliverables and troubleshooting technical challenges. This position offers diverse, impactful work where your expertise significantly contributes to the integrity and success of clinical research programs.
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What cities near Raleigh, NC are hiring for Principal Statistical Programmer jobs? Cities near Raleigh, NC with the most Principal Statistical Programmer job openings:
Infographic showing various Principal Statistical Programmer job openings in Raleigh, NC as of May 2026, with employment types broken down into 100% Full Time. Highlights an 44% In-person, and 56% Remote job distribution, with an average salary of $170,973 per year, or $82.2 per hour.
Epidemiology Analyst (Research Analyst I) in Neurosurgery

Epidemiology Analyst (Research Analyst I) in Neurosurgery

Duke University

Durham, NC • On-site

Full-time

Medical, Dental, Retirement

Posted 18 days ago


Duke University rating

6.5

Company rating: 6.5 out of 10

Based on 54 frontline employees who took The Breakroom Quiz

433rd of 529 rated colleges and universities


Job description

School of Medicine Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,600 faculty physicians and researchers, nearly 2,000 students, and more than 6,200 staff, the Duke University School of Medicine along with the Duke University School of Nursing, and Duke University Health System comprise Duke Health, a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Health Integrated Practice, Duke Primary Care, Duke Home Care and Hospice, Duke Health and Wellness, and multiple affiliations.
Be You.
Working Title: Epidemiology Analyst (Research Analyst I) in Neurosurgery
Occupational Summary
The Ostrom Lab in the Department of Neurosurgery is looking for an experienced research analyst to join our team focused on identifying risk factors for primary and metastatic brain tumors. This role involves providing leadership and expertise in conducting complex research activities, including planning, organizing, conducting, and communicating multiple research epidemiological studies.
This position requires:
• An understanding of core statistical methods and statistical programming for monitoring data quality, modifying and cleaning data for analyses and performing statistical analysis.
• Prior experience with cancer registry data and/or large administrative databases such as Medicare, or Electronic Health record data
• Experience in R programming
• The ability to work independently to perform intermediate and advanced statistical analysis and programming.
• Experience in survival analysis.
• Simultaneous balancing of multiple competing projects and deadlines
• Working in close collaboration with the principal investigator and multi-institutional project teams.
• Interpreting and communicating statistical results and methods.
• Reviewing and editing manuscripts, abstracts, and presentations.
Preferred skills
• Performing complex data management tasks in SAS, R, and/or python.
• Experience in geospatial modeling.
• Experience in analyzing data from genome-wide association studies and related downstream analyses (mendelian randomization, LD score regression).
Be Bold.
Work Performed
Project management (30%)
• Lead, coordinate, and perform a variety of complex independent and team activities involved in the collection, analysis, documentation and interpretation of clinical or genomic related information.
• Coordinate the development of research materials and the application of qualitative and quantitative research techniques; write procedures manuals for data collection and coding.
• Establish work procedures; select sources of information and specific data; Prepare correspondence to locate the specific data required.
• Establish work procedures; select sources of information and specific data.
• Train lower-level personnel and peers in research methodology.
• Supervises the work of lower-level employees and trainees engaged in the data analysis.
• Develops leadership and communication skills and shares them with others.
• Is highly organized, with the initiative, and technical aptitude to work with limited supervision.
• Ability to identify problems and solve them pragmatically.
• Manages project responsibilities and takes initiative to complete project-specific responsibilities with minimal supervision.
• Understands the project scope of work and accurately projects to the time and effort needed to complete each phase of project.
• Recognizes when changes to scope will require significantly more effort than allotted and bring this to the attention of the study team.
• Creates timelines for project management independently.
Statistical analysis (40%)
• Evaluates and interprets data and prepares oral presentations or written reports.
• Confer with principal investigator to discuss the interpretation of results and the preparation of manuscripts for publication.
• Perform data management for multiple types of data including, but not limited to, cancer registry data, patient clinical data, environmental exposure data and genetic data.
• Create analytic datasets, combines multiple disparate raw databases and derives analysis variables accurately.
• Prepares statistical analysis plans in collaboration with principal investigator, other lab members, and outside collaborators.
• Research the literature for modern statistical designs and analyses that can be applied to the data and necessary documentation, learns new statistical methods as needed, and applies new skills to future projects.
• Independently generates descriptive and basic test statistics, data analysis and generates statistical modeling results.
Collaboration (20%)
• Collaborates effectively with principal investigator, research group, and internal/external collaborators.
• Identifies potential data problems from analytic queries and brings them to the attention of the team.
• Demonstrates understanding of project data sets and shares knowledge with collaborators.
• Leads statistical aspects of a research project, with consultation or assistance when needed.
• Represents the functional group in project team meetings and contributes constructively to project discussions.
Dissemination (10%)
• Documents analyses, creates summaries, and presents results in written and verbal form to research teams during project meetings.
• Leads analysis and writing without guidance during all phases of manuscript and report development and revision.
• Independently manuscripts submitted to peer-reviewed journals, abstracts, and grants.
Perform other related duties incidental to the work described herein.
The above statements describe the general nature and level of work being performed by individuals assigned to this classification. This is not intended to be an exhaustive list of all responsibilities and duties required of personnel so classified.
Required Qualifications at this Level
Education/Training
Work requires a Bachelor's degree in a field related to the specific position. A Master's degree in Biostatistics, Epidemiology, Public Health, or a related field is strongly preferred.
Experience
Work requires two years of experience in research/data analysis or related position. Prior contribution to analysis of research projects, a working knowledge of R, and solid command of the English language is required. Has knowledge of the core statistical methods including calculating survival, lifetime risk, prevalence and incidence and statistical programming for monitoring data quality, modifying data for analyses (i.e. data management) and performing statistical analysis. Has knowledge of statistical methods for data that includes genetic and environmental exposure information. Experience with cancer registry data is strongly preferred. Familiarity with SAS, SNP array and/or sequencing data management and analysis is beneficial but not required.
How to apply:
Please submit a cover letter describing your prior research experience, including reference to at least one piece of public-facing scientific or public health material (e.g., published or pre-printed manuscript, poster presentation, oral presentation, cancer surveillance reporting, advocacy materials) to which you have made a substantial contribution and/or another example of a leadership role that you have taken in research or public health.
Choose Duke.
Anticipated Pay Range: Duke University provides an annual base salary range for this position as USD $51,448.00 to USD $77,945.00. Duke University considers factors such as (but not limited to) scope and responsibilities of the position; candidate's work experience, education/training, and key skills; internal peer equity; as well as market and organizational considerations when extending an offer.
Your total compensation goes beyond the dollars on your paycheck. Duke provides comprehensive and competitive medical and dental care programs, generous retirement benefits, and a wide array of family-friendly and cultural programs to eligible team members. Learn more at: https://hr.duke.edu/benefits/
Equal Opportunity Employer: Duke is an Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex (including pregnancy and pregnancy- related conditions), sexual orientation, or military status.
Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas-an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.
Essential Physical Job Functions:
Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and reasonable accommodation(s) can be requested with Duke Access and Accommodations Services (email: DAAS@duke.edu; phone: 919-668-1267).

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About Duke University

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Duke is regarded as one of America's leading research universities. Located in Durham, North Carolina, Duke is positioned in the heart of the Research Triangle, which is ranked annually as one of the best places in the country to work and live. Duke has more than 15,000 students who study and conduct research in its 10 undergraduate, graduate, and professional schools. With about 40,000 employees, Duke is the third largest private employer in North Carolina, and it now has international programs in more than 150 countries.

Industry

Colleges, universities, and professional schools

Company size

10,000+ Employees

Headquarters location

Durham, NC, US

Year founded

1838