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Principal Statistical Programmer Jobs in Raleigh, NC

IQVIA

Principal Statistical Programmer

Durham, NC

$98.20K - $273.20K/yr

Principal Statistical Programmer Start Date: Targeted for midJuly Position Summary We are seeking a Principal Statistical Programmer to provide full endtoend statistical programming support across ...

IQVIA, Inc.

Principal Statistical Programmer

Durham, NC · On-site

$98.20K - $273.20K/yr

Principal Statistical Programmer Start Date: Targeted for mid-July Position Summary We are seeking a Principal Statistical Programmer to provide full end-to-end statistical programming support across ...

IQVIA

Principal Statistical Programmer

Durham, NC · On-site

$98.20K - $273.20K/yr

Principal Statistical Programmer Start Date: Targeted for midJuly Position Summary We are seeking a Principal Statistical Programmer to provide full endtoend statistical programming support across ...

IQVIA

Principal Statistical Programmer

Durham, NC · On-site +1

$158.42K - $227.70K/yr

Principal Statistical Programmer (Multiple Openings), IQVIA RDS Inc. Durham, NC. May telecommute (work from home) from anywhere in the U.S. and report to Durham, NC company location. Plan and ...

IQVIA

Principal Statistical Programmer, PKPD

Durham, NC

$98.20K - $273.20K/yr

PK parameter pooling Experience * 8+ years of statistical programming experience in the pharmaceutical or CRO environment. * Demonstrated experience as a Lead Programmer or technical lead. * Prior ...

IQVIA

Principal Statistical Programmer, PKPD

Durham, NC · On-site

$98.20K - $273.20K/yr

PK parameter pooling Experience * 8+ years of statistical programming experience in the pharmaceutical or CRO environment. * Demonstrated experience as a Lead Programmer or technical lead. * Prior ...

PSI CRO

Principal Statistician

Durham, NC

You will contribute to statistical activities related to global clinical trials and work closely with international teams of statisticians, programmers and data managers, including the role of ...

PSI CRO

Principal Statistician

Durham, NC · On-site +1

You will contribute to statistical activities related to global clinical trials and work closely with international teams of statisticians, programmers and data managers, including the role of ...

PSI CRO

Principal Statistician

Durham, NC

You will contribute to statistical activities related to global clinical trials and work closely with international teams of statisticians, programmers and data managers, including the role of ...

PSI CRO

Principal Statistician

Durham, NC

You will contribute to statistical activities related to global clinical trials and work closely with international teams of statisticians, programmers and data managers, including the role of ...

Fortrea

Principal Biostatistician - FSP

Durham, NC · On-site +1

$115K - $130K/yr

As an experienced Principal Biostatistician in our sponsor-dedicated Flexible Solutions business ... and review Statistical Analysis Plans for data presentation, analyses, and provide programming ...

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How much do principal statistical programmer jobs pay per hour?

As of May 29, 2026, the average hourly pay for principal statistical programmer in Raleigh, NC is $82.20, according to ZipRecruiter salary data. Most workers in this role earn between $70.82 and $94.86 per hour, depending on experience, location, and employer.

What is a Principal Statistical Programmer job?

A Principal Statistical Programmer is a senior-level professional responsible for developing, validating, and maintaining statistical programs used in clinical trials and regulatory submissions. They ensure data accuracy, adherence to industry standards (such as CDISC), and compliance with regulatory requirements. They collaborate with statisticians, data managers, and clinical teams to analyze and report trial results. Additionally, they may mentor junior programmers and contribute to process improvements in statistical programming workflows.

What are the key skills and qualifications needed to thrive in the Principal Statistical Programmer position, and why are they important?

To thrive as a Principal Statistical Programmer, you need advanced expertise in statistical programming (typically with SAS or R), a strong understanding of clinical trial data, and a degree in a relevant field such as statistics, mathematics, or computer science. Familiarity with CDISC standards (SDTM, ADaM), regulatory submission requirements, and project management tools is highly valued, and certifications like SAS Certified Advanced Programmer can be advantageous. Leadership, problem-solving, attention to detail, and excellent communication skills are important for managing complex projects and collaborating across multidisciplinary teams. These skills collectively ensure accuracy, regulatory compliance, and successful delivery of statistical programming support within clinical research environments.

What are the typical daily responsibilities of a Principal Statistical Programmer in a clinical research setting?

As a Principal Statistical Programmer, your daily responsibilities often include developing, validating, and maintaining complex statistical programs to support clinical trial data analysis and regulatory submissions. You may lead programming teams, mentor junior staff, and act as a technical expert on study projects, collaborating closely with statisticians, data managers, and clinical teams. The role frequently involves reviewing statistical analysis plans (SAPs), generating data listings and summary tables, and ensuring adherence to industry standards such as CDISC. Effective communication and time management are key, as you’ll often work on multiple projects simultaneously, balancing deliverables and troubleshooting technical challenges. This position offers diverse, impactful work where your expertise significantly contributes to the integrity and success of clinical research programs.
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Principal Statistical Programmer jobs near you
Infographic showing various Principal Statistical Programmer job openings in Raleigh, NC as of May 2026, with employment types broken down into 100% Full Time. Highlights an 44% In-person, and 56% Remote job distribution, with an average salary of $170,973 per year, or $82.2 per hour.
Principal Statistical Programmer

Principal Statistical Programmer

IQVIA

Durham, NC

$98.20K - $273.20K/yr

Full-time

Posted 7 days ago

IQVIA rating

8.1

Company rating: 8.1 out of 10

Based on 51 frontline employees who took The Breakroom Quiz

54th of 203 rated it services

Job description

Job Title: Principal Statistical Programmer

Start Date: Targeted for midJuly

Position Summary

We are seeking a Principal Statistical Programmer to provide full endtoend statistical programming support across clinical development programs. This role requires deep technical expertise, leadership, and handson delivery, covering SDTM, ADaM, TLF development, and regulatory submission support. The Principal Statistical Programmer will serve as a subject matter expert, ensure highquality deliverables, and contribute to programming standards and best practices.

Key Responsibilities

  • Provide endtoend statistical programming support for clinical studies from study setup through submission
  • Lead and perform development and validation of:
    • SDTM datasets
    • ADaM datasets
    • Tables, Listings, and Figures (TLFs)
  • Ensure all deliverables are compliant with CDISC standards and regulatory requirements
  • Support regulatory submissions (e.g., FDA, EMA), including define.xml, submissionready datasets, and reviewer's guides
  • Serve as a Principallevel programmer, providing technical leadership and guidance to other programmers as needed
  • Contribute to and help maintain programming standards, macros, and validation processes
  • Review and approve programming deliverables to ensure accuracy, consistency, and quality
  • Collaborate closely with Biostatistics, Data Management, Clinical Operations, and Regulatory teams
  • Proactively identify risks and propose efficient, compliant solutions within timelines

Required Qualifications

  • Bachelor's or Master's degree in Statistics, Mathematics, Computer Science, Life Sciences, or related field
  • Extensive experience as a statistical programmer, with demonstrated Principallevel responsibilities
  • Strong handson experience with:
    • SDTM and ADaM dataset development
    • TLF programming
    • Regulatory submission deliverables
  • Expert proficiency in base SAS and Advanced SAS with good hands on SAS Macros
  • Indepth knowledge of CDISC standards, regulatory guidelines, and submission requirements
  • Proven ability to manage complex studies independently from start to finish

IQVIA is a leading global provider of clinical research services, commercial insights and healthcare intelligence to the life sciences and healthcare industries. We create intelligent connections to accelerate the development and commercialization of innovative medical treatments to help improve patient outcomes and population health worldwide. Learn more athttps://jobs.iqvia.com

IQVIA is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, status as a protected veteran, or any other status protected by applicable law. https://jobs.iqvia.com/eoe

IQVIA is committed to integrity in our hiring process and maintains a zero tolerance policy for candidate fraud. All information and credentials submitted in your application must be truthful and complete. Any false statements, misrepresentations, or material omissions during the recruitment process will result in immediate disqualification of your application, or termination of employment if discovered later, in accordance with applicable law. We appreciate your honesty and professionalism.

The potential base pay range for this role, when annualized, is $98,200.00 - $273,200.00. The actual base pay offered may vary based on a number of factors including job-related qualifications such as knowledge, skills, education, and experience; location; and/or schedule (full or part-time). Dependent on the position offered, incentive plans, bonuses, and/or other forms of compensation may be offered, in addition to a range of health and welfare and/or other benefits.

What IQVIA employees say

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About IQVIA

Sourced by ZipRecruiter

At IQVIA, we are passionate about helping customers and partners improve results and patient outcomes. Everything we do contributes to this vision for creating a healthier world. In today’s healthcare environment, it’s not only about how much data, information, and technology you have at your fingertips – it’s what you do with it. IQVIA is focused on making intelligent connections for customers across the entire healthcare ecosystem to help you drive healthcare forward. Whether that means partnering with novel technology companies to boost patient engagement, leveraging AI & machine learning to accelerate results, or using decentralized trials to reach the right patients wherever they are – we are always looking for smarter ways to move you forward.

Industry

Health care and social assistance

Company size

10,000+ Employees

Headquarters location

Durham, NC, US

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