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Principal Statistical Programmer Jobs in Cary, NC

IQVIA

Principal Statistical Programmer

Durham, NC

$98K - $273K/yr

Position Summary We are seeking a Principal Statistical Programmer to provide full endtoend statistical programming support across clinical development programs. This role requires deep technical ...

IQVIA

Principal Statistical Programmer

Durham, NC · On-site

$98K - $273K/yr

Position Summary We are seeking a Principal Statistical Programmer to provide full endtoend statistical programming support across clinical development programs. This role requires deep technical ...

GSK

Principal Statistical Programmer

Durham, NC · On-site

The Principal Statistical Programmer will lead programming activities for one or more studies, ensuring high-quality development, validation, and delivery of complex analysis outputs. Drive technical ...

UCB

Principal Statistical Methodologist (US)

Raleigh, NC · On-site

Make your mark for patients We are looking for a Principal Statistical Methodologist who is curious ... Strong statistical programming skills (R preferred; equivalent tools considered). * Sound knowledge ...

PSI CRO

Principal Statistician

Durham, NC

You will contribute to statistical activities related to global clinical trials and work closely with international teams of statisticians, programmers and data managers, including the role of ...

PSI CRO

Principal Statistician

Durham, NC

You will contribute to statistical activities related to global clinical trials and work closely with international teams of statisticians, programmers and data managers, including the role of ...

PSI CRO

Principal Statistician

Durham, NC · On-site +1

You will contribute to statistical activities related to global clinical trials and work closely with international teams of statisticians, programmers and data managers, including the role of ...

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Principal Statistical Programmer information

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How much do principal statistical programmer jobs pay per hour?

As of Aug 17, 2026, the average hourly pay for principal statistical programmer in Cary, NC is $78.34, according to ZipRecruiter salary data. Most workers in this role earn between $67.50 and $90.43 per hour, depending on experience, location, and employer.

What is a principal statistical programmer?

A Principal Statistical Programmer is a senior-level professional responsible for developing, validating, and maintaining statistical programs used in clinical trials and regulatory submissions. They ensure data accuracy, adherence to industry standards (such as CDISC), and compliance with regulatory requirements. They collaborate with statisticians, data managers, and clinical teams to analyze and report trial results. Additionally, they may mentor junior programmers and contribute to process improvements in statistical programming workflows.

What are the key skills and qualifications needed to thrive in the principal statistical programmer position, and why are they important?

To thrive as a Principal Statistical Programmer, you need advanced expertise in statistical programming (typically with SAS or R), a strong understanding of clinical trial data, and a degree in a relevant field such as statistics, mathematics, or computer science. Familiarity with CDISC standards (SDTM, ADaM), regulatory submission requirements, and project management tools is highly valued, and certifications like SAS Certified Advanced Programmer can be advantageous. Leadership, problem-solving, attention to detail, and excellent communication skills are important for managing complex projects and collaborating across multidisciplinary teams. These skills collectively ensure accuracy, regulatory compliance, and successful delivery of statistical programming support within clinical research environments.

What are the typical daily responsibilities of a principal statistical programmer in a clinical research setting?

As a Principal Statistical Programmer, your daily responsibilities often include developing, validating, and maintaining complex statistical programs to support clinical trial data analysis and regulatory submissions. You may lead programming teams, mentor junior staff, and act as a technical expert on study projects, collaborating closely with statisticians, data managers, and clinical teams. The role frequently involves reviewing statistical analysis plans (SAPs), generating data listings and summary tables, and ensuring adherence to industry standards such as CDISC. Effective communication and time management are key, as you’ll often work on multiple projects simultaneously, balancing deliverables and troubleshooting technical challenges. This position offers diverse, impactful work where your expertise significantly contributes to the integrity and success of clinical research programs.

What are popular job titles related to Principal Statistical Programmer jobs in Cary, NC?

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What job categories do people searching Principal Statistical Programmer jobs in Cary, NC look for?

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Principal Statistical Programmer jobs near you
Infographic showing various Principal Statistical Programmer job openings in Cary, NC as of August 2026, with employment types broken down into 100% Full Time. Highlights an 91% In-person, and 9% Remote job distribution, with an average salary of $162,941 per year, or $78.3 per hour.

Principal Statistical Programmer

IQVIA

Durham, NC

$98K - $273K/yr

Full-time

Re-posted 27 days ago

IQVIA rating

8.1

Company rating: 8.1 out of 10

Based on 53 frontline employees who took The Breakroom Quiz

62nd of 224 rated it services

Job description

Position Summary

We are seeking a Principal Statistical Programmer to provide full endtoend statistical programming support across clinical development programs. This role requires deep technical expertise, leadership, and handson delivery, covering SDTM, ADaM, TLF development, and regulatory submission support. The Principal Statistical Programmer will serve as a subject matter expert, ensure highquality deliverables, and contribute to programming standards and best practices.

Key Responsibilities

  • Provide endtoend statistical programming support for clinical studies from study setup through submission

  • Lead and perform development and validation of:

    • SDTM datasets

    • ADaM datasets

    • Tables, Listings, and Figures (TLFs)

  • Ensure all deliverables are compliant with CDISC standards and regulatory requirements

  • Support regulatory submissions (e.g., FDA, EMA), including define.xml, submissionready datasets, and reviewer's guides

  • Serve as a Principallevel programmer, providing technical leadership and guidance to other programmers as needed

  • Contribute to and help maintain programming standards, macros, and validation processes

  • Review and approve programming deliverables to ensure accuracy, consistency, and quality

  • Collaborate closely with Biostatistics, Data Management, Clinical Operations, and Regulatory teams

  • Proactively identify risks and propose efficient, compliant solutions within timelines

Required Qualifications

  • Bachelor's or Master's degree in Statistics, Mathematics, Computer Science, Life Sciences, or related field

  • Extensive experience as a statistical programmer, with demonstrated Principallevel responsibilities

  • Strong handson experience with:

    • SDTM and ADaM dataset development

    • TLF programming

    • Regulatory submission deliverables

  • Expert proficiency in base SAS and Advanced SAS with good hands on SAS Macros

  • Indepth knowledge of CDISC standards, regulatory guidelines, and submission requirements

  • Proven ability to manage complex studies independently from start to finish

IQVIA is a leading global provider of clinical research services, commercial insights and healthcare intelligence to the life sciences and healthcare industries. We create intelligent connections to accelerate the development and commercialization of innovative medical treatments to help improve patient outcomes and population health worldwide. Learn more athttps://jobs.iqvia.com

IQVIA is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, status as a protected veteran, or any other status protected by applicable law. https://jobs.iqvia.com/eoe

IQVIA is committed to integrity in our hiring process and maintains a zero tolerance policy for candidate fraud. All information and credentials submitted in your application must be truthful and complete. Any false statements, misrepresentations, or material omissions during the recruitment process will result in immediate disqualification of your application, or termination of employment if discovered later, in accordance with applicable law. We appreciate your honesty and professionalism.

The potential base pay range for this role, when annualized, is $98,200.00 - $273,200.00. The actual base pay offered may vary based on a number of factors including job-related qualifications such as knowledge, skills, education, and experience; location; and/or schedule (full or part-time). Dependent on the position offered, incentive plans, bonuses, and/or other forms of compensation may be offered, in addition to a range of health and welfare and/or other benefits.

What IQVIA employees say

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Benefits

Hours and flexibility

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About IQVIA

Sourced by ZipRecruiter

At IQVIA, we are passionate about helping customers and partners improve results and patient outcomes. Everything we do contributes to this vision for creating a healthier world. In today’s healthcare environment, it’s not only about how much data, information, and technology you have at your fingertips – it’s what you do with it. IQVIA is focused on making intelligent connections for customers across the entire healthcare ecosystem to help you drive healthcare forward. Whether that means partnering with novel technology companies to boost patient engagement, leveraging AI & machine learning to accelerate results, or using decentralized trials to reach the right patients wherever they are – we are always looking for smarter ways to move you forward.

Industry

Health care and social assistance

Company size

10,000+ Employees

Headquarters location

Durham, NC, US

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