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Principal Statistical Programmer Jobs in Cary, NC

The Principal Quality Engineer is working in close collaboration with NPI core development teams ... SPC (statistical process control) Preferred Skills & Experience: * Proficiency with Lean ...

Principal Data Scientist

Raleigh, NC · On-site +1

$147K - $243K/yr

... engineering using statistical techniques; data querying and transformation, including SQL; and working with engineering and ML Ops team members to develop and operationalize data science solutions ...

... and Statistics Education, Science Education, and Engineering and Technology Education. The ... Principal administrative liaison between the graduate student, the graduate program, the Directors ...

Project Engineer - Asphalt

Raleigh, NC · On-site

$61K - $78K/yr

Principals ONLY - NO Recruiters Description Who We Are Vinci Construction USA is a full-service ... The Project Engineer will interface with clients, attend meetings, and provide statistical reports ...

Use data and statistical analysis to drive business decisions and target improved results across ... Experience in multiple programming languages, including R and Python. * Deep understanding of GLMs ...

Use data and statistical analysis to drive business decisions and target improved results across ... Experience in multiple programming languages, including R and Python. * Deep understanding of GLMs ...

Showing results 21-40

Principal Statistical Programmer information

See Cary, NC salary details

$51

$78

$108

How much do principal statistical programmer jobs pay per hour?

As of Sep 7, 2026, the average hourly pay for principal statistical programmer in Cary, NC is $78.34, according to ZipRecruiter salary data. Most workers in this role earn between $67.50 and $90.43 per hour, depending on experience, location, and employer.

What is a principal statistical programmer?

A Principal Statistical Programmer is a senior-level professional responsible for developing, validating, and maintaining statistical programs used in clinical trials and regulatory submissions. They ensure data accuracy, adherence to industry standards (such as CDISC), and compliance with regulatory requirements. They collaborate with statisticians, data managers, and clinical teams to analyze and report trial results. Additionally, they may mentor junior programmers and contribute to process improvements in statistical programming workflows.

What are the typical daily responsibilities of a principal statistical programmer in a clinical research setting?

As a Principal Statistical Programmer, your daily responsibilities often include developing, validating, and maintaining complex statistical programs to support clinical trial data analysis and regulatory submissions. You may lead programming teams, mentor junior staff, and act as a technical expert on study projects, collaborating closely with statisticians, data managers, and clinical teams. The role frequently involves reviewing statistical analysis plans (SAPs), generating data listings and summary tables, and ensuring adherence to industry standards such as CDISC. Effective communication and time management are key, as you’ll often work on multiple projects simultaneously, balancing deliverables and troubleshooting technical challenges. This position offers diverse, impactful work where your expertise significantly contributes to the integrity and success of clinical research programs.

What are the key skills and qualifications needed to thrive in the principal statistical programmer position, and why are they important?

To thrive as a Principal Statistical Programmer, you need advanced expertise in statistical programming (typically with SAS or R), a strong understanding of clinical trial data, and a degree in a relevant field such as statistics, mathematics, or computer science. Familiarity with CDISC standards (SDTM, ADaM), regulatory submission requirements, and project management tools is highly valued, and certifications like SAS Certified Advanced Programmer can be advantageous. Leadership, problem-solving, attention to detail, and excellent communication skills are important for managing complex projects and collaborating across multidisciplinary teams. These skills collectively ensure accuracy, regulatory compliance, and successful delivery of statistical programming support within clinical research environments.

What are popular job titles related to Principal Statistical Programmer jobs in Cary, NC?

For Principal Statistical Programmer jobs in Cary, NC, the most frequently searched job titles are:

What job categories do people searching Principal Statistical Programmer jobs in Cary, NC look for?

The top searched job categories for Principal Statistical Programmer jobs in Cary, NC are:

What cities near Cary, NC are hiring for Principal Statistical Programmer jobs?

Cities near Cary, NC with the most Principal Statistical Programmer job openings:

Infographic showing various Principal Statistical Programmer job openings in Cary, NC as of August 2026, with employment types broken down into 88% Full Time, 10% Part Time, 1% Temporary, and 1% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $162,941 per year, or $78.3 per hour.

$143K - $229K/yr

Full-time

Medical, Retirement, PTO

Re-posted yesterday


Key responsibilities

  • Lead the development and testing of hypotheses across all functional data sets

  • Design and develop scalable, efficient data pipeline processes for data ingestion, cleansing, transformation, integration, and validation

  • Identify actionable insights, suggest recommendations, and communicate results to cross-functional groups


Blue Cross and Blue Shield of North Carolina rating

7.8

Company rating: 7.8 out of 10

Based on 13 frontline employees who took The Breakroom Quiz

197th of 315 rated insurance


Job description

Job Description

The Principal Data Scientist will serve as the principal lead to provide accurate and quality analyses that translate data in sound organizational decisions. In this role you will provide strategic thought leadership and partner with other functional areas to deliver collaborative work products that align with divisional and enterprise strategy. You will own delivery of multiple large and/or complex data science and engineering projects.

What You'll Do

  • Lead in the development and testing of hypotheses across all functional data sets

  • Lead requirements gathering sessions with business and technical staff to distill technical requirement from business requests

  • Define and implement integrated data models, allowing integration of data from multiple sources

  • Design and develop scalable, efficient data pipeline processes to handle data ingestion, cleansing, transformation, integration, and validation

  • Define and implement data stores based on system requirements and consumer requirements

  • Design and develop models to understand and solve multiple complex business solutions using a variety of methods including data mining, statistical analysis, predictive modeling and analysis, stochastic modeling, pattern recognition, probability analysis, and network analysis

  • Design and implement production models leveraging technologies such Python, and R

  • Leverage existing data sets and engineer new data sets including development of SQL queries, data integration and resolution of data quality issues

  • Apply advanced conceptual understanding of Big Data systems to data set engineering and analytic model implementation

  • Lead development and reviews of complex analytic models and algorithms

  • Identify actionable insights, suggest recommendations, and influence business direction by effectively communicating results to cross functional groups

  • Document and test analytic processes including performance and thorough data validation and verification

  • Engage with enterprise business areas to incorporate feedback into audit process including but not limited to Payment Integrity, SIU, Provider, Behavioral Health, Med Policy, Claims, Pharmacy
  • Articulate analytic methods and drive business outcomes with responsible business areas
  • Consult with executive level leadership across the organization- with responsibility to drive CoC ideation for Commercial and Medicare
  • Informally lead other analysts and synthesize information and make recommendations to executive leadership
What You Bring
  • Bachelor's degree or advanced degree (where required)

  • 8+ years of experience in related field.

  • In lieu of degree, 10+ years of experience in related field.

  • Strong Analytic/Data Science skills:

  • Experience with Snowflake

  • Experience building AI Agents

  • Understand Bell curve analysis

  • Incorporate Industry benchmarks into analysis

  • Perform outlier detection

  • Strong healthcare experience with Payment Integrity/FWA business knowledge is required

  • understanding of FWA concepts, CMS guidelines, Medical/Reimbursement Policy are all strongly preferred

Salary Range

At Blue Cross NC, we take great pride in a fair and equitable compensation package that reflects market-price and our starting salaries are typically planned near the middle of the range listed. Compensation decisions are driven by factors including experience and training, specialized skill sets, licensure and certifications and other business and organizational needs.Our base salary is part of a robust Total Rewards package that includes an Annual Incentive Bonus, 401(k) with employer match, Paid Time Off (PTO), and competitive health benefits and wellness programs.

Based on annual corporate goal achievement and individual performance.

$143,616.00 - $229,786.00

Skills

Big Data, Complex Data Analysis, Data Analysis, Data Engineering, Data Mining, Data Modeling Techniques, Data Science, Data Visualization, Machine Learning (ML), Predictive Analytics, Predictive Modeling, Python (Programming Language), Statistical Analysis, Statistical Models

_____________________________________________________________________
JOB ALERT FRAUD: We have become aware of scams from individuals, organizations, and internet sites claiming to represent Blue Cross and Blue Shield of North Carolina in recruitment activities in return for disclosing financial information. Our hiring process does not include text-based conversations or interviews and never requires payment or fees from job applicants. All our career opportunities are published on https://bcbsnc.wd5.myworkdayjobs.com/en-US/BCBSNC. If you have already provided your personal information that you suspect is fraudulent activity, please report it to your local authorities. Any fraudulent activity should be reported to: HR.Staffing@BCBSNC.com.


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