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Principal Statistical Programmer Jobs (NOW HIRING)

IQVIA, Inc.

Principal Statistical Programmer

Durham, NC · On-site

$98.20K - $273.20K/yr

Principal Statistical Programmer Start Date: Targeted for mid-July Position Summary We are seeking a Principal Statistical Programmer to provide full end-to-end statistical programming support across ...

IQVIA

Principal Statistical Programmer

Durham, NC

$98.20K - $273.20K/yr

Principal Statistical Programmer Start Date: Targeted for midJuly Position Summary We are seeking a Principal Statistical Programmer to provide full endtoend statistical programming support across ...

IQVIA

Principal Statistical Programmer

Durham, NC

$98.20K - $273.20K/yr

Principal Statistical Programmer Start Date: Targeted for midJuly Position Summary We are seeking a Principal Statistical Programmer to provide full endtoend statistical programming support across ...

IQVIA

Principal Statistical Programmer

Durham, NC

$98.20K - $273.20K/yr

Principal Statistical Programmer Start Date: Targeted for midJuly Position Summary We are seeking a Principal Statistical Programmer to provide full endtoend statistical programming support across ...

IQVIA

Principal Statistical Programmer

Durham, NC

$98.20K - $273.20K/yr

Principal Statistical Programmer Start Date: Targeted for midJuly Position Summary We are seeking a Principal Statistical Programmer to provide full endtoend statistical programming support across ...

Vrtx

Principal Statistical Programmer

Boston, MA · Remote

$149.20K - $223.80K/yr

The Principal Statistical Programmer works with management to delegate tasks appropriately, track progress, and provide expert technical support to team members. In addition, the Principal ...

ImmunityBio, Inc.

Principal Statistical Programmer

Position Summary A Principal Statistical Programmer is an expert in management, technical oversight, and quality of statistical programming activities related to the analyses of clinical trial data ...

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How much do principal statistical programmer jobs pay per hour?

As of Jun 1, 2026, the average hourly pay for principal statistical programmer in the United States is $84.56, according to ZipRecruiter salary data. Most workers in this role earn between $72.84 and $97.60 per hour, depending on experience, location, and employer.

What is a Principal Statistical Programmer job?

A Principal Statistical Programmer is a senior-level professional responsible for developing, validating, and maintaining statistical programs used in clinical trials and regulatory submissions. They ensure data accuracy, adherence to industry standards (such as CDISC), and compliance with regulatory requirements. They collaborate with statisticians, data managers, and clinical teams to analyze and report trial results. Additionally, they may mentor junior programmers and contribute to process improvements in statistical programming workflows.

What are the key skills and qualifications needed to thrive in the Principal Statistical Programmer position, and why are they important?

To thrive as a Principal Statistical Programmer, you need advanced expertise in statistical programming (typically with SAS or R), a strong understanding of clinical trial data, and a degree in a relevant field such as statistics, mathematics, or computer science. Familiarity with CDISC standards (SDTM, ADaM), regulatory submission requirements, and project management tools is highly valued, and certifications like SAS Certified Advanced Programmer can be advantageous. Leadership, problem-solving, attention to detail, and excellent communication skills are important for managing complex projects and collaborating across multidisciplinary teams. These skills collectively ensure accuracy, regulatory compliance, and successful delivery of statistical programming support within clinical research environments.

What are the typical daily responsibilities of a Principal Statistical Programmer in a clinical research setting?

As a Principal Statistical Programmer, your daily responsibilities often include developing, validating, and maintaining complex statistical programs to support clinical trial data analysis and regulatory submissions. You may lead programming teams, mentor junior staff, and act as a technical expert on study projects, collaborating closely with statisticians, data managers, and clinical teams. The role frequently involves reviewing statistical analysis plans (SAPs), generating data listings and summary tables, and ensuring adherence to industry standards such as CDISC. Effective communication and time management are key, as you’ll often work on multiple projects simultaneously, balancing deliverables and troubleshooting technical challenges. This position offers diverse, impactful work where your expertise significantly contributes to the integrity and success of clinical research programs.
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Principal Statistical Programmer jobs near you
Principal Statistical Programmer

Principal Statistical Programmer

IQVIA, Inc.

Durham, NC • On-site

$98.20K - $273.20K/yr

Full-time

Posted 10 days ago

IQVIA rating

8.1

Company rating: 8.1 out of 10

Based on 51 frontline employees who took The Breakroom Quiz

53rd of 203 rated it services

Job description

Job Title: Principal Statistical Programmer
Start Date: Targeted for mid-July
Position Summary
We are seeking a Principal Statistical Programmer to provide full end-to-end statistical programming support across clinical development programs. This role requires deep technical expertise, leadership, and hands-on delivery, covering SDTM, ADaM, TLF development, and regulatory submission support. The Principal Statistical Programmer will serve as a subject matter expert, ensure high-quality deliverables, and contribute to programming standards and best practices.
Key Responsibilities
  • Provide end-to-end statistical programming support for clinical studies from study setup through submission
  • Lead and perform development and validation of:
    • SDTM datasets
    • ADaM datasets
    • Tables, Listings, and Figures (TLFs)
  • Ensure all deliverables are compliant with CDISC standards and regulatory requirements
  • Support regulatory submissions (e.g., FDA, EMA), including define.xml, submission-ready datasets, and reviewer's guides
  • Serve as a Principal-level programmer, providing technical leadership and guidance to other programmers as needed
  • Contribute to and help maintain programming standards, macros, and validation processes
  • Review and approve programming deliverables to ensure accuracy, consistency, and quality
  • Collaborate closely with Biostatistics, Data Management, Clinical Operations, and Regulatory teams
  • Proactively identify risks and propose efficient, compliant solutions within timelines

Required Qualifications
  • Bachelor's or Master's degree in Statistics, Mathematics, Computer Science, Life Sciences, or related field
  • Extensive experience as a statistical programmer, with demonstrated Principal-level responsibilities
  • Strong hands-on experience with:
    • SDTM and ADaM dataset development
    • TLF programming
    • Regulatory submission deliverables
  • Expert proficiency in base SAS and Advanced SAS with good hands on SAS Macros
  • In-depth knowledge of CDISC standards, regulatory guidelines, and submission requirements
  • Proven ability to manage complex studies independently from start to finish

IQVIA is a leading global provider of clinical research services, commercial insights and healthcare intelligence to the life sciences and healthcare industries. We create intelligent connections to accelerate the development and commercialization of innovative medical treatments to help improve patient outcomes and population health worldwide. Learn more at https://jobs.iqvia.com
IQVIA is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, status as a protected veteran, or any other status protected by applicable law. https://jobs.iqvia.com/eoe
IQVIA is committed to integrity in our hiring process and maintains a zero tolerance policy for candidate fraud. All information and credentials submitted in your application must be truthful and complete. Any false statements, misrepresentations, or material omissions during the recruitment process will result in immediate disqualification of your application, or termination of employment if discovered later, in accordance with applicable law. We appreciate your honesty and professionalism.
The potential base pay range for this role, when annualized, is $98,200.00 - $273,200.00. The actual base pay offered may vary based on a number of factors including job-related qualifications such as knowledge, skills, education, and experience; location; and/or schedule (full or part-time). Dependent on the position offered, incentive plans, bonuses, and/or other forms of compensation may be offered, in addition to a range of health and welfare and/or other benefits.

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About IQVIA

Sourced by ZipRecruiter

At IQVIA, we are passionate about helping customers and partners improve results and patient outcomes. Everything we do contributes to this vision for creating a healthier world. In today’s healthcare environment, it’s not only about how much data, information, and technology you have at your fingertips – it’s what you do with it. IQVIA is focused on making intelligent connections for customers across the entire healthcare ecosystem to help you drive healthcare forward. Whether that means partnering with novel technology companies to boost patient engagement, leveraging AI & machine learning to accelerate results, or using decentralized trials to reach the right patients wherever they are – we are always looking for smarter ways to move you forward.

Industry

Health care and social assistance

Company size

10,000+ Employees

Headquarters location

Durham, NC, US

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