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Principal Statistical Programmer Jobs in Houston, TX

Principal AI/ML Software Engineer

Houston, TX · On-site

$128K - $172K/yr

Principal AI/ML Software Engineer Job Location (Short): Houston, Texas-USA | Madison, Alabama-USA ... Strong foundation in statistics, A/B testing, causal inference, and experimental design • ...

Principal Data Engineer

Houston, TX · On-site

$106K - $127K/yr

Principal Data Engineer Location: Houston, TX - 4 days/week onsite Duration: Full time / Direct ... Bachelor's Degree Computer Science, Data Science, MIS, Engineering, Mathematics, Statistics or ...

Build LLM-powered solutions using prompt engineering, fine-tuning, inference optimization, and agent-based architectures. Business Decision Support * Convert statistical and ML findings into ...

Principal AI Data Scientist

Spring, TX · On-site

$147K - $230K/yr

Principal AI Data Scientist Description - About the Position The HP Enterprise AI & Machine ... and statistical modeling. Preferred Certifications Programming Language/s Certification (SQL ...

You build and run the A/B testing program with statistical rigor (orthogonal testing with intention ... You're able to pull and interpret funnel + behavioral data without always going through engineering ...

You build and run the A/B testing program with statistical rigor (orthogonal testing with intention ... You're able to pull and interpret funnel + behavioral data without always going through engineering ...

You build and run the A/B testing program with statistical rigor (orthogonal testing with intention ... You're able to pull and interpret funnel + behavioral data without always going through engineering ...

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Principal Statistical Programmer information

See Houston, TX salary details

$53

$80

$111

How much do principal statistical programmer jobs pay per hour?

As of Aug 10, 2026, the average hourly pay for principal statistical programmer in Houston, TX is $80.75, according to ZipRecruiter salary data. Most workers in this role earn between $69.57 and $93.22 per hour, depending on experience, location, and employer.

What is a principal statistical programmer?

A Principal Statistical Programmer is a senior-level professional responsible for developing, validating, and maintaining statistical programs used in clinical trials and regulatory submissions. They ensure data accuracy, adherence to industry standards (such as CDISC), and compliance with regulatory requirements. They collaborate with statisticians, data managers, and clinical teams to analyze and report trial results. Additionally, they may mentor junior programmers and contribute to process improvements in statistical programming workflows.

What are the key skills and qualifications needed to thrive in the principal statistical programmer position, and why are they important?

To thrive as a Principal Statistical Programmer, you need advanced expertise in statistical programming (typically with SAS or R), a strong understanding of clinical trial data, and a degree in a relevant field such as statistics, mathematics, or computer science. Familiarity with CDISC standards (SDTM, ADaM), regulatory submission requirements, and project management tools is highly valued, and certifications like SAS Certified Advanced Programmer can be advantageous. Leadership, problem-solving, attention to detail, and excellent communication skills are important for managing complex projects and collaborating across multidisciplinary teams. These skills collectively ensure accuracy, regulatory compliance, and successful delivery of statistical programming support within clinical research environments.

What are the typical daily responsibilities of a principal statistical programmer in a clinical research setting?

As a Principal Statistical Programmer, your daily responsibilities often include developing, validating, and maintaining complex statistical programs to support clinical trial data analysis and regulatory submissions. You may lead programming teams, mentor junior staff, and act as a technical expert on study projects, collaborating closely with statisticians, data managers, and clinical teams. The role frequently involves reviewing statistical analysis plans (SAPs), generating data listings and summary tables, and ensuring adherence to industry standards such as CDISC. Effective communication and time management are key, as you’ll often work on multiple projects simultaneously, balancing deliverables and troubleshooting technical challenges. This position offers diverse, impactful work where your expertise significantly contributes to the integrity and success of clinical research programs.

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What job categories do people searching Principal Statistical Programmer jobs in Houston, TX look for? The top searched job categories for Principal Statistical Programmer jobs in Houston, TX are:
Infographic showing various Principal Statistical Programmer job openings in Houston, TX as of August 2026, with employment types broken down into 95% Full Time, and 5% Nights. Highlights an 86% In-person, 5% Hybrid, and 9% Remote job distribution, with an average salary of $167,964 per year, or $80.8 per hour.

Principal Data Scientist

Augment Professional Services

Houston, TX • On-site

Full-time

Re-posted 8 days ago


Job description

About Augment Professional Services (APS)

Augment Professional Services (APS) delivers specialized talent, consulting expertise, and project support to organizations operating in complex technical environments. Our teams partner with clients across the Technology, Energy, Utilities, and EPC sectors to support critical initiatives in digital transformation, data and analytics, infrastructure modernization, and engineering delivery.

Through a flexible services model that includes managed services, project-based delivery, and embedded technical expertise, APS helps organizations accelerate innovation, scale capabilities, and execute high-impact initiatives with confidence.


Position Overview

We are seeking a Principal Data Scientist with deep expertise in Artificial Intelligence, Large Language Models (LLMs), Natural Language Processing (NLP), Computer Vision (CV), and Generative AI.

This role will serve as a technical leader and architect of AI-driven solutions, responsible for designing, building, and deploying advanced machine learning systems that deliver measurable business impact. The ideal candidate brings both strong technical depth and the ability to translate complex AI methodologies into real-world applications.

The Principal Data Scientist will work closely with cross-functional stakeholders, engineers, and leadership to drive innovation through scalable AI solutions and production-ready machine learning systems.

Key responsibilities include:

  • Designing and developing advanced machine learning and deep learning models

  • Building solutions leveraging Large Language Models (LLMs), Generative AI, NLP, and Computer Vision

  • Architecting scalable AI and ML pipelines from experimentation through production deployment

  • Developing and optimizing models through fine-tuning, prompt engineering, and inference optimization

  • Building end-to-end machine learning workflows including data ingestion, feature engineering, training, evaluation, deployment, and monitoring

  • Translating complex data science methodologies into actionable insights and business strategies

  • Partnering with business leaders to identify opportunities where AI can drive innovation and operational efficiency

  • Communicating technical concepts and model outcomes to both technical and non-technical stakeholders

  • Mentoring data scientists and helping establish best practices for model development and MLOps

Required Technical Skills Position Overview
  • Strong expertise in Artificial Intelligence and Machine Learning, including:

    • Natural Language Processing (NLP)

    • Computer Vision (CV)

    • Generative AI

    • Deep Learning

  • Hands-on experience working with:

    • Large Language Models (LLMs)

    • Prompt engineering and model fine-tuning

    • Multi-agent AI architectures

    • Model optimization and inference efficiency

  • Experience building and deploying production-scale machine learning systems

  • Proficiency with modern ML frameworks and ecosystems such as:

    • Python

    • PyTorch or TensorFlow

    • Hugging Face

    • LangChain or similar LLM frameworks

  • Familiarity with MLOps practices, scalable AI infrastructure, and data pipelines

Required Soft Skills
  • Curious and Innovative: Passionate about solving complex business problems using data and AI

  • Ownership and Initiative: Ability to drive projects from concept through deployment

  • Business Acumen: Understanding of how AI and machine learning solutions support business outcomes

  • Effective Communication: Ability to explain technical models and AI methodologies to non-technical audiences

  • Collaborative Leadership: Ability to work effectively across engineering, product, and business teams

Preferred Qualifications
  • Master’s or Ph.D. in a quantitative field such as:

    • Computer Science

    • Data Science

    • Statistics

    • Engineering

    • Applied Mathematics

    • Economics

  • Experience developing and deploying Generative AI or deep learning models in production environments

  • Experience working with large-scale datasets and enterprise AI platforms

Equal Opportunity Statement

Augment Professional Services and our client partners are committed to fostering inclusive and diverse workplaces. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other legally protected characteristic in accordance with applicable laws.