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Principal Statistical Programmer Jobs in Raleigh, NC

PSI CRO

Principal Statistician

Durham, NC · On-site

You will contribute to statistical activities related to global clinical trials and work closely with international teams of statisticians, programmers and data managers, including the role of ...

Itron, Inc

Principal Quality Engineer

Raleigh, NC · Hybrid

The Principal Quality Engineer is working in close collaboration with NPI core development teams ... SPC (statistical process control) Preferred Skills & Experience: * Proficiency with Lean ...

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All JobsPrincipal Statistical Programmer JobsPrincipal Statistical Programmer Jobs in Raleigh, NC

Principal Statistical Programmer information

See Raleigh, NC salary details

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How much do principal statistical programmer jobs pay per hour?

As of Aug 20, 2026, the average hourly pay for principal statistical programmer in Raleigh, NC is $82.19, according to ZipRecruiter salary data. Most workers in this role earn between $70.82 and $94.86 per hour, depending on experience, location, and employer.

What is a principal statistical programmer?

A Principal Statistical Programmer is a senior-level professional responsible for developing, validating, and maintaining statistical programs used in clinical trials and regulatory submissions. They ensure data accuracy, adherence to industry standards (such as CDISC), and compliance with regulatory requirements. They collaborate with statisticians, data managers, and clinical teams to analyze and report trial results. Additionally, they may mentor junior programmers and contribute to process improvements in statistical programming workflows.

What are the typical daily responsibilities of a principal statistical programmer in a clinical research setting?

As a Principal Statistical Programmer, your daily responsibilities often include developing, validating, and maintaining complex statistical programs to support clinical trial data analysis and regulatory submissions. You may lead programming teams, mentor junior staff, and act as a technical expert on study projects, collaborating closely with statisticians, data managers, and clinical teams. The role frequently involves reviewing statistical analysis plans (SAPs), generating data listings and summary tables, and ensuring adherence to industry standards such as CDISC. Effective communication and time management are key, as you’ll often work on multiple projects simultaneously, balancing deliverables and troubleshooting technical challenges. This position offers diverse, impactful work where your expertise significantly contributes to the integrity and success of clinical research programs.

What are the key skills and qualifications needed to thrive in the principal statistical programmer position, and why are they important?

To thrive as a Principal Statistical Programmer, you need advanced expertise in statistical programming (typically with SAS or R), a strong understanding of clinical trial data, and a degree in a relevant field such as statistics, mathematics, or computer science. Familiarity with CDISC standards (SDTM, ADaM), regulatory submission requirements, and project management tools is highly valued, and certifications like SAS Certified Advanced Programmer can be advantageous. Leadership, problem-solving, attention to detail, and excellent communication skills are important for managing complex projects and collaborating across multidisciplinary teams. These skills collectively ensure accuracy, regulatory compliance, and successful delivery of statistical programming support within clinical research environments.

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What job categories do people searching Principal Statistical Programmer jobs in Raleigh, NC look for?

The top searched job categories for Principal Statistical Programmer jobs in Raleigh, NC are:

What cities near Raleigh, NC are hiring for Principal Statistical Programmer jobs?

Cities near Raleigh, NC with the most Principal Statistical Programmer job openings:

Principal Statistical Programmer jobs near you
Infographic showing various Principal Statistical Programmer job openings in Raleigh, NC as of August 2026, with employment types broken down into 87% Full Time, 10% Part Time, 1% Temporary, and 2% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $170,964 per year, or $82.2 per hour.

Principal Statistician

PSI CRO

Durham, NC • On-site

Full-time

Re-posted 14 days ago

Job description

Company Description

We are the company that cares - for our staff, for our clients, for our partners and for the quality of work we do. A dynamic, global company founded in 1995, we bring together more than 2,700 driven, dedicated and passionate individuals. We work on the frontline of medical science, changing lives, and bringing new medicines to those who need them.

Job Description

You will contribute to statistical activities related to global clinical trials and work closely with international teams of statisticians, programmers and data managers, including the role of biostatistics project lead.

In this role, you will:

  • Act as a communication line for project teams, clients, vendors and internal team on statistical questions
  • Conduct statistical analysis for clinical trials including, interim analysis, final analysis, analysis for DSMBs/DMCs and PK analysis
  • Develop and review study protocols, statistical analysis plans, analysis dataset specifications according to CDISC ADaM standard and other project-specific documents
  • Review statistical deliverables such as tables, figures, listings and analysis datasets
  • Conduct departmental induction course and project-specific training for statisticians and SAS programmers
  • Prepare for and attend internal and external study audits pertinent to Statistics
  • Participate in preparation of internal/external audits follow up
  • Provide input to standard operating procedures and other Quality Systems Documents (QSDs) pertinent to activities of Biostatistics department
  • Liaise with DM on statistical questions related to data issues
  • Participate in bid defense and in kick-off meetings
  • Lead teams of SAS programmers and/or statisticians on the project level
Qualifications
  • MSc in Statistics or equivalent
  • Expert knowledge and understanding of the statistical principles, concepts, methods, and standards used in clinical research
  • Expert knowledge and understanding of the SAS programming
  • Expert knowledge and understanding of CDISC ADaM standard
  • Expert knowledge and understanding of adaptive designs
  • Expert knowledge and understanding of sample size calculation
  • Expert knowledge and understanding of relevant regulations and guidelines (e.g. FDA, EMA, ICH)
  • Ability to apply advanced statistical techniques in support of clinical research studies and to analyze, interpret, and draw conclusions from complex statistical information
  • Ability to consult with clinical investigators, interpret research requirements, and determine statistical analysis strategies
  • Strong presentation and communication skills
Additional Information

Our mission is to be the best CRO in the world as measured by our employees, clients, sites, and vendors. Our recruitment process is easy and straightforward, and we'll be there with you every step of the way. 

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