Job Summary:
Ramona is reimagining microscopy for modern biology. They are seeking a Computational Imaging Engineer to develop calibration procedures and improve image quality for their Multi-Camera Array Microscope platform.
Responsibilities:
• Develop rigorous, systematic, and mathematically grounded calibration procedures for multi-axis, multi-magnification optical instruments.
• Characterize sensor and image noise sources and build models to quantify and correct for them.
• Model and correct optical and geometric image deformations introduced by the imaging system.
• Design and implement high-performance deconvolution algorithms to recover image detail across a range of numerical apertures.
• Develop methods for background estimation, source characterization, and background subtraction in microscopy images.
• Characterize how motion-system accuracy and mechanical vibration affect image formation, and develop approaches to mitigate their impact.
• Characterize illumination sources and their contribution to image quality, and develop correction strategies.
• Characterize fluorescence imaging performance — including excitation/emission behavior, photobleaching, spectral crosstalk, and signal-to-background ratio — across magnifications and sample types, as a critical input to system calibration.
• Investigate the optical properties of diverse sample materials and assess their variability, building this understanding into the system's calibration and analysis pipelines.
• Translate optical systems models and computer vision techniques into robust, production-ready software that integrates with the broader imaging platform.
• Collaborate closely with optics, mechatronics, and software engineers to validate calibration approaches against real instrument behavior.
• Document calibration methodologies, models, and validation procedures for internal and external use.
• Evaluate and adopt emerging techniques in computational imaging, optical systems modeling, and computer vision to improve calibration accuracy and scalability.
Qualifications:
Required:
• Bachelor's or Master's degree in Optical Engineering, Physics, Electrical Engineering, or a related field (or equivalent experience).
• 2+ years of experience.
• Strong foundation in the mathematics and physics underlying image formation, including Fourier optics, signal processing, and linear algebra.
• Hands-on experience with image deconvolution, deblurring, or related inverse-problem techniques.
• Experience characterizing noise, background, or illumination effects in optical or imaging systems.
• Experience with geometric or optical calibration of imaging or measurement systems.
• Strong proficiency in Python (or similar) for scientific computing and image processing.
• Familiarity with how mechanical accuracy, vibration, or motion-system behavior affects image quality.
• Strong problem-solving skills, attention to detail, and scientific curiosity.
• Ability to communicate clearly and collaborate across disciplines spanning optics, mechatronics, and software.
• Experience with computer vision techniques relevant to image registration, restoration, or quantitative analysis.
Preferred:
• Master's or Ph.D. degree in Optics, Physics, or a closely related field.
• 5+ years of experience.
• Experience with optical systems modeling or simulation tools.
• Experience working on multi-axis or multi-magnification imaging instruments.
Company:
Ramona develops high-throughput microscopy tools to unlock previously impossible experiments within the modern biology lab. Founded in 2018, the company is headquartered in Durham, USA, with a team of 11-50 employees. The company is currently Early Stage.