The qualifications that you need to get an office assistant job with no experience include a high school diploma or GED certificate and clerical or administrative skills. Some employers prefer entry-level applicants who have a postsecondary certificate or associate degree in business administration or a related field, but this is not always necessary. Most jobs require familiarity with Microsoft Office software, schedule management applications, and data entry systems. This job involves communicating over the phone and face-to-face with clients and colleagues, so you need the ability to communicate confidently and clearly. Entry-level workers need to be willing to undergo additional training if needed.