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Manager Biotherapeutics Jobs (NOW HIRING)

Manifold Bio

Senior Director, Biotherapeutics

Boston, MA

$240K - $340K/yr

Manage and mentor internal protein scientists and protein engineers * Build and focus teams in a ... Foster strong collaborative interactions between biotherapeutics teams and teams supporting AI/ML ...

Vrtx

Executive Director, Biotherapeutics DMPK

Boston, MA · On-site

$268K - $402K/yr

This leader will be based in Boston but manage and oversee the work of DMPK-BA teams at our Vertex ... Develop vision, strategy, and capabilities for the Biotherapeutics DMPK-BA teams across Boston and ...

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How much do manager biotherapeutics jobs pay per year?

As of Jun 15, 2026, the average yearly pay for manager biotherapeutics in the United States is $61,351.00, according to ZipRecruiter salary data. Most workers in this role earn between $44,000.00 and $69,000.00 per year, depending on experience, location, and employer.

What are Manager Biotherapeutics?

A Manager Biotherapeutics is a professional responsible for overseeing teams and projects involved in the research, development, and production of biotherapeutic products such as monoclonal antibodies, vaccines, and cellular therapies. They coordinate scientific activities, manage budgets, ensure compliance with regulatory standards, and facilitate collaboration between cross-functional teams. Their role is crucial in advancing new biologic medicines from research to market while maintaining quality, safety, and efficiency throughout the process.

What are the key skills and qualifications needed to thrive as a Manager Biotherapeutics, and why are they important?

To thrive as a Manager Biotherapeutics, you need a solid background in life sciences or biotechnology, leadership experience, and expertise in drug development processes. Familiarity with laboratory information management systems (LIMS), regulatory compliance tools, and project management software is typically required, along with relevant certifications such as PMP or advanced degrees (e.g., Ph.D., MSc). Strong interpersonal, organizational, and problem-solving skills help foster effective team collaboration and drive project success. These skills and qualifications are essential for ensuring regulatory adherence, optimizing research outcomes, and leading teams in the fast-paced biotherapeutics sector.

How does a Manager Biotherapeutics typically collaborate with cross-functional teams during the drug development process?

A Manager Biotherapeutics works closely with multidisciplinary teams, including research scientists, regulatory affairs, clinical operations, and manufacturing. They coordinate project timelines, ensure alignment on objectives, and facilitate communication between departments to drive biotherapeutic programs forward. Regular meetings, detailed project tracking, and problem-solving sessions are common, and the role often requires balancing scientific rigor with business priorities. This collaborative approach is essential for successful development and timely delivery of biotherapeutic products.
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Manager Biotherapeutics jobs near you
Infographic showing various Manager Biotherapeutics job openings in the United States as of June 2026, with employment types broken down into 85% Full Time, 14% Part Time, and 1% Contract. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $61,351 per year, or $29.5 per hour.
Senior Director, Biotherapeutics

Senior Director, Biotherapeutics

Manifold Bio

Boston, MA

$240K - $340K/yr

Other

Medical, Dental, Vision, Retirement, PTO

Posted yesterday

Job description

Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.
Position:

Manifold Bio is seeking an exceptional Senior Director of Biotherapeutics to help guide and mature our discovery, characterization, and production of shuttled therapeutics. This role spans discovery and nonclinical development, including bioengineering strategies to generate best-in-class molecules and oversight of external contract manufacturing organizations (CDMOs) to develop processes and manufacture drug product for clinical trials.

As a member of our leadership team, you will contribute to high-level strategy and help build internal resources to support our ambitious growth plans. This is a unique opportunity to shape the future of a cutting-edge biotechnology company while working with a collaborative, innovative team.

Key Responsibilities:

Team Management & Development

  • Manage and mentor internal protein scientists and protein engineers
  • Build and focus teams in a capital-efficient manner to support current and future pipeline needs
  • Foster strong collaborative interactions between biotherapeutics teams and teams supporting AI/ML protein design and screening, oligonucleotide therapeutic discovery, and pharmacology

Program Execution

  • Support the discovery and characterization of shuttled therapeutics via 1-2 matrix project teams, serving as biotherapeutics lead or project lead
  • Map out critical path activities through IND-enabling studies and ensure key activities are resourced and executed efficiently
  • Engage with consultants, contractors and  CROs/CDMOs to efficiently build expertise and capabilities that accelerate program progression
  • Set and implement strategy for developability assessment and early-stage de-risking
  • Prepare and present data packages for partnering discussions and investor presentations

Strategic Leadership

  • Contribute to high-level strategy and key objectives for discovery and development of shuttled therapeutics
  • Establish development candidate nomination criteria for novel biotherapeutics with particular focus on developability metrics 
  • Identify and outline opportunities for backup molecule discovery and selection
Qualifications:

Required Experience & Skills

  • Extensive experience in biotherapeutics across a range of protein modalities
  • Proven track record engineering antibodies for clinical development
  • Deep knowledge of state-of-the-art protein engineering approaches
  • Experience with protein expression systems, purification methods, and characterization including developability assays
  • Prior experience liaising with CDMOs

Preferred Qualifications

  • Expertise with novel modalities and complex formats, including ADCs, tissue-targeted therapeutics, and bispecific antibodies
  • Understanding of high-throughput screening and bioanalytical technologies
  • Experience with generative AI models for protein and/or oligonucleotide design

Base Salary Range: $240,000-340,000

This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate's experience, interview performance, and expected impact.

This role is eligible for:

  • Annual performance-based target bonus
  • Stock options
  • Comprehensive medical, dental, and vision coverage
  • 401(k) plan
  • Flexible paid time off and holidays
  • Perks including on-site gym, onsite lunch, and commuter support

Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.

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