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Home Based Principal Investigator Jobs (NOW HIRING)

Celerion

Principal Investigator

Lincoln, NE · On-site

Pre-Study: • Review protocol and Investigator Brochure for subject safety, scientific, and ... Review pre-dose lab work, ECGs, and other study data and determine appropriate action plan based on ...

Celerion

Principal Investigator

Lincoln, NE

Review protocol and Investigator Brochure for subject safety, scientific, and operational ... Review pre-dose lab work, ECGs, and other study data and determine appropriate action plan based on ...

Celerion

Principal Investigator

Lincoln, NE

Pre-Study: · Review protocol and Investigator Brochure for subject safety, scientific, and ... Review pre-dose lab work, ECGs, and other study data and determine appropriate action plan based on ...

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Home Based Principal Investigator information

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$19.5K

$142.7K

$260.5K

How much do home based principal investigator jobs pay per year?

As of Sep 6, 2026, the average yearly pay for home based principal investigator in the United States is $142,668.00, according to ZipRecruiter salary data. Most workers in this role earn between $86,000.00 and $200,000.00 per year, depending on experience, location, and employer.

What is the difference between Home Based Principal Investigator vs Clinical Research Coordinator?

AspectHome Based Principal InvestigatorClinical Research Coordinator
Required credentialsMedical degree or relevant advanced degree, research experienceBachelor's degree, research training, certification often preferred
Work environmentLeading research projects, overseeing study conduct, often remotely or in clinicsManaging daily study activities, recruiting participants, data collection
Employer and industry usageResearch institutions, hospitals, pharmaceutical companiesResearch sites, hospitals, clinics

The Home Based Principal Investigator typically holds advanced medical credentials and oversees clinical studies, often working remotely or in clinical settings. In contrast, a Clinical Research Coordinator manages day-to-day study tasks, focusing on participant recruitment and data collection. Both roles are essential in clinical research but differ in responsibilities, credentials, and work environment.

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Home Based Principal Investigator jobs near you
Infographic showing various Home Based Principal Investigator job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 77% Full Time, 16% Part Time, and 6% Contract. Highlights an 88% Physical, 2% Hybrid, and 10% Remote job distribution, with an average salary of $142,668 per year, or $68.6 per hour.

Neurologist Principal Investigator

Irvine Clinical Research

Long Beach, CA • On-site

$300K - $350K/yr

Full-time

Medical, Dental, Vision, PTO

Re-posted 6 hours ago

Job description

Irvine Clinical Research is the largest independent clinical research site network on the West Coast. With 5 research centers in California, we are leaders in the search for new treatments in neurology, psychiatry, and obesity medicine. Our largest area of research is in Alzheimer's Disease prevention and treatment drug trials, and our doctors were the largest contributors in the world to the most recently FDA-approved medication in Alzheimer's Disease.
 
Irvine Clinical Research is hiring a Neurologist who will serve as a Principal Investigator. The physician will oversee Phase 1, 2, and 3 clinical trials of some of the most promising drugs under investigation in memory disorders and other neurological conditions. This includes next-generation disease-modifying anti-amyloid therapies in the same class as donanemab and lecanemab, anti-tau agents, and novel therapies like antisense oligonucleotides (ASOs).
 
Our hiring needs vary per location (Inglewood, Long Beach, Oakland, Riverside), so please indicate any preferred locations in your application.
Job Duties
  • Lead study team as a Principal or Sub-Investigator, ensuring trials are conducted safely and per protocol
  • Conduct clinical intake interviews to determine medical eligibility of potential study participants
  • Educate potential participants about diseases and the benefits of clinical trial participation
  • Manage the safety of study participants; respond appropriately to adverse events in a timely manner
  • Perform cerebrospinal fluid collection (lumbar puncture) in diagnostic and therapeutic studies
  • Provide medical leadership to our team of psychologists and study coordinators
Job Requirements
  • Valid license to practice medicine in California (or license-eligible)
  • Board-certified in neurology or psychiatry
  • Experience working with older adults in a clinical or research setting
  • Clinical research experience is preferred, but not required
  • A command of professional spoken and written English
$300,000 - $350,000 a year
Hours and Compensation
This is a full-time employment position based in-person at one of our clinics (Riverside, Inglewood, Long Beach, or Oakland). There are no planned overnight or weekend hours.
 
The starting salary for this position is $300,000 per year. Higher salary is available with candidates meet one of the following criteria: (1) current/previous investigator in pharmaceutical clinical trials of Alzheimer's Disease (2) superior skill in intrathecal administration and CSF collection in clinic.
 
The company pays for 100% of health/dental/vision individual insurance costs for eligible full-time employees. Vacation (PTO) is earned at a rate of 3 weeks per year.
 
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