ZipRecruiter

Log In

1

High Content Imaging Jobs (NOW HIRING)

Biohub

Manager/ Director, Engineering

Chicago, IL · On-site

Oversee integration of molecular measurement technologies (e.g., spatial omics, proteomics, high-content imaging) directly into automated pipelines. * Develop custom hardware, fixtures, and ...

Transcripta Bio

Computational Biologist

Palo Alto, CA · On-site

... high-content imaging data. * Analyze data from drug perturbation screens to identify transcriptomic signatures, compound-gene associations, and patterns of drug response across disease-relevant cell ...

Medra

Research Associate - Protein

San Francisco, CA · On-site

Familiarity with imaging-based cell assays (e.g., high-content imaging, fluorescence microscopy) * Experience with cell-free protein expression or specialized enzyme workflows * Comfort working with ...

New

Mayo Clinic

Research Fellow - Neurology

Rochester, MN · On-site

The fellow will design and execute experiments that combine advanced stem-cell culture and differentiation, CRISPR-based perturbations, high-content imaging, electrophysiology, and transcriptomic ...

Biohub

Scientist, Stem Cell Genomics

San Francisco, CA · On-site +1

The successful candidate will develop and implement single-cell and multi-omics approaches in human stem cell systems, and integrate these with CRISPR-based perturbation and high-content imaging ...

next page

Showing results 1-20

People also search for

All JobsHigh Content Imaging Jobs

High Content Imaging information

See salary details

$15

$38

$77

How much do high content imaging jobs pay per hour?

As of Jun 7, 2026, the average hourly pay for high content imaging in the United States is $38.91, according to ZipRecruiter salary data. Most workers in this role earn between $26.20 and $45.19 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a High Content Imaging Specialist, and why are they important?

To thrive as a High Content Imaging Specialist, expertise in cell biology, image analysis, and microscopy, often with an advanced degree in a life science field, is essential. Familiarity with high-throughput imaging platforms (such as PerkinElmer Opera Phenix or Molecular Devices ImageXpress), image analysis software (like CellProfiler or ImageJ), and data management systems is typically required. Strong problem-solving skills, attention to detail, and effective communication are crucial for optimizing assays and collaborating with cross-functional teams. These competencies ensure accurate data acquisition, reliable experimental results, and successful integration of imaging technologies in research workflows.

What are some common challenges faced by professionals working in High Content Imaging, and how can they be addressed?

Professionals in High Content Imaging often encounter challenges such as managing large volumes of data, ensuring image quality and consistency, and troubleshooting complex imaging equipment. These challenges can be addressed by developing strong data management skills, staying current with image analysis software, and collaborating closely with IT and instrument support teams. Additionally, regular training on new technologies and maintaining clear documentation can help ensure smooth workflows and minimize downtime.

What is high content imaging?

High content imaging is an advanced microscopy technique used primarily in biological and pharmaceutical research to capture and analyze large volumes of complex cellular data. It combines high-resolution imaging with automated data analysis to assess multiple cellular features simultaneously, making it a powerful tool for drug discovery, toxicity testing, and cell biology studies. This approach enables researchers to gather quantitative information from thousands of cells in a single experiment, increasing efficiency and data quality. High content imaging often uses fluorescence labeling and sophisticated software to extract meaningful biological insights from images.

What is the difference between High Content Imaging vs Cell Imaging Specialist?

AspectHigh Content ImagingCell Imaging Specialist
Required CredentialsBachelor's or higher in biology, biochemistry, or related fields; experience with microscopy and imaging softwareSimilar credentials; often includes microscopy and cell biology expertise
Work EnvironmentResearch labs, pharmaceutical companies, biotech firmsLaboratories focusing on cell analysis, drug discovery, or biomedical research
Industry UsageUsed across biotech, pharma, academic researchPrimarily in research and development settings within biotech and pharma
Common Search/ComparisonHigh Content Imaging vs Cell Imaging Specialist

High Content Imaging involves automated microscopy and image analysis to study cellular responses on a large scale, often used in drug screening. Cell Imaging Specialist focuses on detailed microscopy of cells, emphasizing manual or semi-automated imaging techniques. While both roles require microscopy skills and biological knowledge, High Content Imaging emphasizes high-throughput analysis, whereas Cell Imaging Specialists focus on detailed cellular visualization.

What cities are hiring for High Content Imaging jobs? Cities with the most High Content Imaging job openings:
What states have the most High Content Imaging jobs? States with the most job openings for High Content Imaging jobs include:
What job categories do people searching High Content Imaging jobs look for? The top searched job categories for High Content Imaging jobs are:
High Content Imaging jobs near you
Analytical Development Senior Research Scientist, Imaging Assay Development

Analytical Development Senior Research Scientist, Imaging Assay Development

Vertex Pharmaceuticals

Boston, MA • On-site

$122K - $183K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 21 days ago

Job description

Job Description
General Summary:
We are seeking a highly motivated and experienced Senior Scientist to join our Analytical Development team. The successful candidate will play a critical role in the development, optimization, and transfer of imaging-based assays to automation platforms or quality control (QC) environments. This position requires a strong background in analytical development, imaging technologies, and assay automation, as well as a proven ability to work collaboratively in a cross-functional team environment.
Key Duties and Responsibilities:
  • Assay Development:
    • Design, develop, optimize, qualify/validate imaging-based assays to support drug development and manufacturing processes.
    • Evaluate and implement advanced imaging technologies to enhance assay sensitivity, specificity, and throughput.
    • Develop robust and reproducible methods for quantitative image analysis.
  • Technology Transfer:
    • Lead the transfer of imaging-based assays to automation platforms or QC environments, ensuring compliance with regulatory requirements and industry standards.
    • Collaborate with cross-functional teams, including automation engineers, quality assurance, and manufacturing, to ensure seamless assay implementation.
    • Provide technical support and training to QC teams for assay execution and troubleshooting.
  • Data Analysis and Interpretation:
    • Analyze and interpret complex imaging data to support decision-making in product development and quality control.
    • Develop and qualify/validate data analysis pipelines and algorithms for imaging-based assays.
  • Documentation and Compliance:
    • Author and review technical documents, including protocols, reports, and standard operating procedures (SOPs).
    • Ensure compliance with regulatory guidelines (e.g., FDA, ICH, USP) and internal quality standards.
  • Collaboration and Leadership:
    • Act as a subject matter expert (SME) for imaging-based assays within the organization.
    • Mentor and train junior scientists and research associates.
  • Collaborate with cross-functional teams, including research, process development, and quality assurance, to support project goals.

Knowledge and Skills:
Required:
  • Understanding of analytical development for biologics, cell and genetic therapy products
  • Image-based assay expertise: IHC, IF
  • Experience or knowledge in confocal microscopy, and image-based high throughput instruments (e.g. Opera, Operetta, CX7 and FlowCam)
  • Strong knowledge of imaging technologies, image acquisition, and analysis software (e.g., ImageJ, CellProfiler, or similar tools).
  • Technical expertise in mammalian cell culture, and cell based assays.
  • Ability to multi-task as necessary, managing competing priorities and advancing multiple projects within required timelines
  • Strong communication skills and a willingness to reach out across teams to accomplish program goals
  • Familiar with regulatory (FDA, ICH, USP, etc) guidance surrounding analytical assay development for cell based assays.
  • Experience working collaboratively across teams to achieve analytical development goals
  • Participation on global development teams(s) where contributions are made to form CMC strategy is preferred

Preferred:
  • Strong background in analytical method development, qualification, validation and tech transfer for cell therapy product.
  • A background in stem cell biology, experience with stem cell (ESC, iPSC) derived cell therapy product.
  • Familiar with regulatory guidance and experience with regulatory filing for CGT products

Other: Flexible team player excited to collaborate with internal and external partners.
Education and Experience:
  • Ph.D. in Biology, Cell biology, Biochemistry or a related field with 3-5+ years of relevant industry experience, or M.S. with 5+ years of relevant industry experience, or a BS/BA with 8+ years of relevant industry experience.
  • Proven expertise in developing and optimizing imaging-based assays (e.g., fluorescence microscopy, high-content imaging, or other imaging modalities).
  • Experience with assay transfer to automated platforms or QC environments is highly desirable.
  • Preferred: 3+ years of relevant industry experience in the cell and gene therapy analytical assay development.

Pay Range:
$122,400 - $183,600
Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
On-Site Designated
Flex Eligibility Status:
In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.
#LI-Onsite
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

Apply