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High Content Imaging Jobs (NOW HIRING)

Broad Institute

Senior Research Scientist I

Cambridge, MA · On-site

$115K - $161K/yr

We use systematic approaches in genomics, biology, high content imaging, chemistry, and machine learning coupled with the Broad's culture of creativity, risk taking, and open sharing, to successfully ...

Aequor

Scientist

South San Francisco, CA

Candidates with prior exposure to high-content imaging assays, small molecule support work, and complex biological assay development are highly preferred. The hiring manager is seeking a highly ...

Arcadia Science

Imaging Specialist

Emeryville, CA

The core is built to enable high-content imaging of diverse organisms -- from 2 to 250 µm, on timescales from milliseconds to hours -- using both label-free and reporter-based approaches. Our ...

Arcadia Science

Imaging Specialist

Emeryville, CA · On-site

The core is built to enable high-content imaging of diverse organisms - from 2 to 250 m, on timescales from milliseconds to hours - using both label-free and reporter-based approaches. Our current ...

Arcadia Science

Imaging Specialist

Emeryville, CA · On-site

The core is built to enable high-content imaging of diverse organisms - from 2 to 250 µm, on timescales from milliseconds to hours - using both label-free and reporter-based approaches. Our current ...

Nikon Inc.

Advanced Biosystems Specialist

Seattle, WA · On-site

$110K/yr

Job Type Full-time Description Overall responsibility is to increase sales and market penetration of confocal, multiphoton, super resolution, high content, and other laser-based imaging systems ...

Nikon Inc

Advanced Biosystems Specialist

Melville, NY · On-site

$70K - $110K/yr

Overall responsibility is to increase sales and market penetration of confocal, multiphoton, super resolution, high content, and other laser-based imaging systems within a multi-state territory and ...

UL Research Institutes

NC · On-site

This role primarily supports the generation of high-throughput high-content imaging (e.g., Cell Painting) data by performing laboratory experiments, generation, analysis, and interpretation of ...

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How much do high content imaging jobs pay per hour?

As of Jun 7, 2026, the average hourly pay for high content imaging in the United States is $38.91, according to ZipRecruiter salary data. Most workers in this role earn between $26.20 and $45.19 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a High Content Imaging Specialist, and why are they important?

To thrive as a High Content Imaging Specialist, expertise in cell biology, image analysis, and microscopy, often with an advanced degree in a life science field, is essential. Familiarity with high-throughput imaging platforms (such as PerkinElmer Opera Phenix or Molecular Devices ImageXpress), image analysis software (like CellProfiler or ImageJ), and data management systems is typically required. Strong problem-solving skills, attention to detail, and effective communication are crucial for optimizing assays and collaborating with cross-functional teams. These competencies ensure accurate data acquisition, reliable experimental results, and successful integration of imaging technologies in research workflows.

What are some common challenges faced by professionals working in High Content Imaging, and how can they be addressed?

Professionals in High Content Imaging often encounter challenges such as managing large volumes of data, ensuring image quality and consistency, and troubleshooting complex imaging equipment. These challenges can be addressed by developing strong data management skills, staying current with image analysis software, and collaborating closely with IT and instrument support teams. Additionally, regular training on new technologies and maintaining clear documentation can help ensure smooth workflows and minimize downtime.

What is high content imaging?

High content imaging is an advanced microscopy technique used primarily in biological and pharmaceutical research to capture and analyze large volumes of complex cellular data. It combines high-resolution imaging with automated data analysis to assess multiple cellular features simultaneously, making it a powerful tool for drug discovery, toxicity testing, and cell biology studies. This approach enables researchers to gather quantitative information from thousands of cells in a single experiment, increasing efficiency and data quality. High content imaging often uses fluorescence labeling and sophisticated software to extract meaningful biological insights from images.

What is the difference between High Content Imaging vs Cell Imaging Specialist?

AspectHigh Content ImagingCell Imaging Specialist
Required CredentialsBachelor's or higher in biology, biochemistry, or related fields; experience with microscopy and imaging softwareSimilar credentials; often includes microscopy and cell biology expertise
Work EnvironmentResearch labs, pharmaceutical companies, biotech firmsLaboratories focusing on cell analysis, drug discovery, or biomedical research
Industry UsageUsed across biotech, pharma, academic researchPrimarily in research and development settings within biotech and pharma
Common Search/ComparisonHigh Content Imaging vs Cell Imaging Specialist

High Content Imaging involves automated microscopy and image analysis to study cellular responses on a large scale, often used in drug screening. Cell Imaging Specialist focuses on detailed microscopy of cells, emphasizing manual or semi-automated imaging techniques. While both roles require microscopy skills and biological knowledge, High Content Imaging emphasizes high-throughput analysis, whereas Cell Imaging Specialists focus on detailed cellular visualization.

What cities are hiring for High Content Imaging jobs? Cities with the most High Content Imaging job openings:
What states have the most High Content Imaging jobs? States with the most job openings for High Content Imaging jobs include:
What job categories do people searching High Content Imaging jobs look for? The top searched job categories for High Content Imaging jobs are:
High Content Imaging jobs near you
Senior Research Scientist I

Senior Research Scientist I

Broad Institute

Cambridge, MA • On-site

$115K - $161K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 24 days ago

Job description

General information
Location
Cambridge, MA
Ref #
44143
Job Family
Research
Date published
05/12/2026
Time Type
Full time
Pay Range
$115,000.00/yr - $161,667.00/yr
Description & Requirements
Embedded within the Broad Institute, the Center for the Development of Therapeutics (CDoT)) is a highly collaborative organization of professional drug discovery scientists. Our mission is to translate cutting edge biological insights originating from the Broad community into impactful drug discovery projects. We partner with faculty from MIT, Harvard, and the Harvard teaching hospitals together with industry partners in pharmaceutical, biotechnology and venture capital firms to validate druggable targets and identify leads. We combine our deep expertise in drug discovery with the knowledge and unique capabilities of the Broad Institute to explore drug discovery projects in a wide range of disease areas (including oncology, cardiovascular, psychiatry, infectious and rare diseases). We use systematic approaches in genomics, biology, high content imaging, chemistry, and machine learning coupled with the Broad's culture of creativity, risk taking, and open sharing, to successfully advance science and develop new treatments for patients.
We are seeking a passionate and highly motivated Senior Research Scientist to join CDoT's High Content Imaging (HCI) team. This role is designed for an experienced scientist who thrives at the intersection of complex biology and high-throughput technology. You will be part of a collaborative team developing cutting edge high content imaging methodologies, including small molecule, genetic and chemical perturbation screening, to advance therapeutic and basic biology projects.
The ideal candidate blends deep technical expertise in molecular and cell biology, high content imaging and data analysis with a "systems-thinking" approach to operational efficiency and automation.
PRINCIPLE DUTIES AND RESPONSIBILITIES
Essential Functions
  • Methodology Leadership: Drive the design, optimization, and implementation of next-generation HCI assays, including screening workflows.
  • Scale & Automation: Partner with automation engineers to transition bench-scale assays into robust, high-throughput production pipelines.
  • Cross-Functional Collaboration: Act as a technical bridge between cellular biologists, data scientists, and ML engineers to ensure data quality and biological relevance.
  • Strategic Innovation: Evaluate and integrate emerging technologies in small molecule screening, perturbation biology and imaging to maintain the Broad's competitive edge.
  • Mentorship: Provide technical guidance and project leadership to junior scientists and research associates within the HCI ecosystem, management of scientists and/or research assistants.
  • High content imaging expertise: High level of enthusiasm for exploring and implementing new molecular and cell-based technologies related to High Content Imaging.
  • Work Style: Exceptional flexibility and a willingness to pivot strategies within a fast-paced, dynamic research environment.
  • Communication: Ability to communicate complex technical concepts to diverse stakeholders, from public representatives, donors, and institutional leadership to cellular biologists, automation engineers, data scientists and software engineers.

Additional Desirable Capabilities
  • HCI Software Ecosystem: Direct familiarity with High Content Imaging pipelines, specifically Revvity Harmony, Image Artist, and Signal applications.
  • Automation & Robotics: Hands-on experience with high-throughput 384-well plate handling using a variety of liquid handling and robotic-based automation platforms.
  • Optical Pooled Screening: Previous experience or theoretical grounding in OPS workflows and analysis.
  • Advanced Analytics: Application of Machine Learning classification models to biological imaging data.

MINIMUM QUALIFICATIONS Required
  • PhD in Molecular or Cellular Biology or related field with 5+ years of relevant experience
  • Experience managing and/or mentoring scientists or research associates
  • Extensive experience working with cells of diverse origins and various genetic/chemical perturbation approaches.
  • Significant experience with genetic (CRISPR, RNAi) and chemical perturbations in complex cellular models.
  • Significant experience developing phenotypic image-based assays suitable for small molecule or genetic screening
  • A proven track record of working at scale and a keen appreciation for process optimization and reproducibility.
  • Proven ability to process large-scale datasets, including expertise in:
  • Preprocessing: Normalization, batch correction, and rigorous Quality Control (QC).
  • Analysis: Data exploration and visualization using Dimensionality Reduction (e.g., UMAP, t-SNE) and Clustering.

The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law.
At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits.
The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations.
Should you need a reasonable accommodation to complete the application or interview process, please contact recruiting@broadinstitute.org for assistance.

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