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Head Of Clinical Operations Jobs (NOW HIRING)

Forhyre

Head of Clinical Operations

New York, NY · On-site

We are looking for a competent Head of Clinical Operations who will own critical functions across the business, including expansion strategy, new vertical launches, supply chain management, clinical ...

Carda Health

Head of Clinical Operations

As Head of Clinical Operations, you will own the full clinical delivery infrastructure at Carda Health. You will build and lead the teams, systems, and processes that power our virtual cardiac and ...

Argenta

Manager of Clinical Operations

Shawnee, KS · Hybrid

This role will work closely with the Head of US Clinical on leading the execution of the US ... This is an exciting opportunity for a technically sound operational leader who thrives in high ...

Argenta

Manager of Clinical Operations

Shawnee, KS · Remote

This role will work closely with the Head of US Clinical on leading the execution of the US ... This is an exciting opportunity for a technically sound operational leader who thrives in high ...

Argenta

Manager of Clinical Operations

Shawnee, KS · On-site

This role will work closely with the Head of US Clinical on leading the execution of the US ... This is an exciting opportunity for a technically sound operational leader who thrives in high ...

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Head Of Clinical Operations information

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$60K

$146K

$282.5K

How much do head of clinical operations jobs pay per year?

As of Aug 7, 2026, the average yearly pay for head of clinical operations in the United States is $145,969.00, according to ZipRecruiter salary data. Most workers in this role earn between $102,000.00 and $173,500.00 per year, depending on experience, location, and employer.

What is the difference between Head Of Clinical Operations vs Clinical Operations Manager?

AspectHead Of Clinical OperationsClinical Operations Manager
ResponsibilitiesOversees entire clinical operations, strategic planning, and leadershipManages daily clinical trial activities, team supervision, and project execution
Required CredentialsTypically advanced degrees (e.g., MSc, PhD), extensive industry experienceBachelor’s or Master’s degree, relevant industry experience
Work EnvironmentSenior leadership, cross-departmental collaboration, strategic focusOperational setting, team management, project-focused

The Head Of Clinical Operations is a senior leadership role responsible for strategic oversight of clinical trials, while the Clinical Operations Manager handles day-to-day trial management. Both roles require industry experience and relevant credentials, but differ in scope and level of responsibility.

How does the head of clinical operations typically interact with cross-functional teams during a clinical trial?

As the Head of Clinical Operations, you will regularly collaborate with teams across clinical development, data management, regulatory affairs, and medical affairs. Your role often involves leading project meetings, aligning timelines, and ensuring that all departments are working toward common trial goals. This cross-functional collaboration is crucial for addressing challenges, maintaining compliance, and delivering trials on schedule. Strong communication and leadership skills are essential, as you will frequently act as the primary point of contact between internal teams and external partners such as CROs.

What are the key skills and qualifications needed to thrive as a head of clinical operations?

To thrive as a Head Of Clinical Operations, you need strong leadership in clinical management, deep knowledge of regulatory requirements, and experience in healthcare administration, typically supported by an advanced degree in a health-related field. Familiarity with clinical trial management systems (CTMS), electronic data capture (EDC) platforms, and often certifications like PMP or Lean Six Sigma are common requirements. Outstanding communication, problem-solving, and strategic planning skills set top candidates apart in this role. These competencies are crucial for ensuring efficient clinical processes, regulatory compliance, and the successful delivery of high-quality patient care and research outcomes.
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Head Of Clinical Operations jobs near you
Infographic showing various Head Of Clinical Operations job openings in the United States as of August 2026, with employment types broken down into 85% Full Time, 12% Part Time, 1% Temporary, and 2% Contract. Highlights an 94% Physical, 2% Hybrid, and 4% Remote job distribution, with an average salary of $145,969 per year, or $70.2 per hour.

Head of Clinical Operations

Kumquat Biosciences Inc

San Diego, CA • On-site

$225K - $325K/yr

Full-time

Posted 24 days ago

Job description

We are looking for a highly experienced and results-driven Head of Clinical Operations to join our team at Kumquat Biosciences. As the Head of Clinical Operations, you will be responsible for overseeing the planning, execution, and delivery of clinical trial programs in collaboration with the medical product leads. This individual will oversee clinical operations across multiple studies and be responsible for operational excellence to meet corporate and clinical program goals. An ideal candidate is a strategic thinker with deep experience in clinical operations and cross-functional collaboration with excellent communication skills in the life sciences or healthcare industry.
Key Responsibilities:
  • Oversee the day-to-day clinical operations team, including Clinical Operations Study Leads (COSLs), Clinical Research Associates (CRAs), and other operations staff.
  • Develop and implement SOPs, work instructions, tools, templates, workflows, and study-level performance metrics to optimize operational efficiency and compliance.
  • Strike new and manage existing business relationships with CROs, clinical sites, vendors, and consultants to ensure high-quality vendor performance and financial accountability.
  • Collaborate with Medical, Clinical Science, Data Management, Quality Assurance, Regulatory, Clinical Supply, Regulatory and other departments to support clinical development programs.
  • Perform as a key member of a product development team to provide timelines, budgets, feasibility, and product strategy
  • Support COSLs in study start-up, development of study budgets, plans, and timely and quality study execution with excellent vendor oversight.
  • Monitor clinical trial progress, identify risks and mitigation strategies, and provide regular updates to leadership.
  • Help strategize with study teams for rapid study start-up, site initiation, accruals to assigned product trials, and rapid database locks (60 days or less).
  • Ensure compliance with ICH-GCP guidelines, FDA regulations, and other applicable global regulatory requirements.
  • Lead and mentor team members, fostering a high-performance culture and supporting professional development.
  • Help lead inspection readiness initiative and regulatory authority inspections/audits. Be a key member of the audit response team.

Requirements
  • Bachelor's degree in a related field (Life Sciences, Nursing, etc.).
  • Minimum of 12 years of clinical research experience, including 5+ years in a leadership or management role.
  • Experience in early-phase oncology trials, and/or immunology and inflammation (I & I) trials, biomarker driven therapy, and small molecule drugs
  • Clinical operations lead of a minimum of 1 prior successful product approval and NDA submission with experience of a minimum of 1 accelerated approval pathway and compressed regulatory timelines
  • Experience in global clinical trials, early and late phase research
  • Strong understanding of clinical development processes, ICH-GCP, FDA, and international regulatory requirements.
  • Proven track record of successfully managing global clinical trials across all phases.
  • Excellent leadership, communication, and interpersonal skills.
  • Ability to thrive in a fast-paced, dynamic, and collaborative environment.

Salary Description
$225k - $325k

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