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The Mayo Clinic Department of Neuroscience is recruiting an exceptional scientist (PhD, MD/PhD, MD or equivalent) who is a leading expert in neurodegenerative and related diseases to establish a robust research program at Mayo Clinic. The candidate is expected to have an outstanding track record in innovative scientific discovery with strong translational component in areas including biomarker discoveries, novel therapeutic approaches such as RNA and cellular therapies, utilizing human data, biospecimens and model systems to accelerate discoveries toward disease-modifying therapies and cures. This individual will integrate efforts across sites and disciplines such as Neuroscience, Neurology, Artificial Intelligence and Pathology and Laboratory Medicine to leverage large-scale human datasets and biospecimens. By combining expertise in human disease biology, model systems, brain health, and aging, this scientist will uncover key disease mechanisms and drive predictive and therapeutic advances in neurodegenerative and related disorders. The ideal candidate will have a track record of basic and translational science discoveries, experience engaging with business development, and will be poised to take advantage of large-scale, multi-PI research opportunities from the National Institutes of Health (NIH), ARPA and other funding agencies. The candidate will be eligible for all faculty privileges and be involved in the education of trainees.
Qualifications
The candidate will have strong expertise and experience in basic and translational research in neurodegeneration and related disorders, brain health and disease, from mechanisms to cures. The ideal candidate is expected to have a history of extramural funding, high impact publications, as well as a proven record of collaborative team science endeavors. This scientist will have a track record of basic and translational science research approaches including but not limited to model systems such as animal or human stem cell-based models, cell biology, and/or genetic engineering to uncover biological basis of disease and treatment thereof. The candidate will be expected to develop and apply these tools for generating diagnostic, prognostic, preventative or therapeutic applications in collaboration with other investigators and taking advantage of the innovative, translational environment at Mayo Clinic. The required qualifications include the following:

• Ph.D., M.D., M.D./Ph.D. or equivalent degree in a relevant discipline

• Academic rank of Associate Professor or Professor, or equivalent rank

• Proven track record of robust, sustained and current grant funding from the National Institutes of Health (NIH) and other federal agencies and national/international renown

• An exceptional and innovative investigator (physician-scientist or scientist) with demonstrated scientific excellence and previous leadership/administrative/management experience in academic medicine or biopharma

The position will be located at the Mayo Clinic Florida site in Jacksonville.
The Department of Neuroscience
The Department of Neuroscience is internationally recognized for academic excellence with a specific focus on understanding the etiology and developing diagnostic and treatment methods for complex neurologic diseases, including neurodegenerative dementias, movement, neurovascular, neuroimmune disorders and aging. The Department spans all Mayo Clinic sites and includes 28 primary and 12 joint faculty members, 58 allied health staff, 57 postdoctoral associates, and 53 doctoral students. Scientists within the neuroscience department have strong expertise in neurogenomics, neuropathology, disease modeling, molecular and cell biology, immunity, and experimental therapeutics. The Department faculty play key roles in the Alzheimer's Disease Research Center and other large-scale NIH-funded consortia. In 2025, the total cost of grant funding to the Department of Neuroscience was $284M, the majority of which was from federal grants. Our faculty holds leadership roles on major NIH and foundation programs including but not limited to AMP-AD, CLEAR-AD, Dementia with Lewy Bodies Consortium, Tau Center without walls.
Highlights of Mayo Clinic Research Enterprise:

• Over 5,200 research personnel, including 321 faculty level research investigators and 948 physicians who are actively involved in research.

• 11,220 peer-reviewed papers were published in 2024.

• Investments in research each year that result in hundreds of new clinical trials. In 2024, the institution received over $753 million in extramural research awards supplemented with over $517 million of institutional support.

• Nearly 10,000 active studies involving human participants in progress. Nearly 6,000 research grants and contracts.

• State-of-the art laboratories and shared resource facilities, including those for microscopy and imaging, cell and molecular biology, animal models, production of iPS cells and clinical grade MSCs, biomedical engineering and mathematics, materials testing, a Medical Genomics Facility, a Mouse Modeling Facility, Molecular and Microscopic Core Facilities, and unique Human Disease Tissue Banks.

• Over 470,000 square feet of research laboratory space includes several robotic freezers capable of storing 3.5 million DNA samples.

• Mayo Clinic supports innovation and has a wealth of resources available - including an integrated health record and collaboration with top specialists.

• Mayo Clinic Brain Bank housed within the Department of Neuroscience and including 11,000 unique brains with neuropathologic characterizations from donors with neurodegenerative diseases and other conditions.

Applications should include a full CV/Bibliography, statement of research interests, and the names/contact information of five references. Please reach out to Natalie Brewster, Physician/Scientist Recruiter with questions: Brewster.natalie@mayo.edu
About Us
Why Mayo Clinic
Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans - to take care of you and your family, now and in the future. And with continuing education and advancement opportunities at every turn, you can build a long, successful career with Mayo Clinic.
Benefits Highlights

• Medical: Multiple plan options.
• Dental: Delta Dental or reimbursement account for flexible coverage.
• Vision: Affordable plan with national network.
• Pre-Tax Savings: HSA and FSAs for eligible expenses.
• Retirement: Competitive retirement package to secure your future.

About the Team
Just as our reputation has spread beyond our Minnesota roots, so have our locations. Today, our employees are located at our three major campuses in Phoenix/Scottsdale, Arizona, Jacksonville, Florida, Rochester, Minnesota, and at Mayo Clinic Health System campuses throughout Midwestern communities, and at our international locations. Each Mayo Clinic location is a special place where our employees thrive in both their work and personal lives. Learn more about what each unique Mayo Clinic campus has to offer, and where your best fit is.
Equal Opportunity
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status or disability status. Learn more about the "EOE is the Law". Mayo Clinic participates in E-Verify and may provide the Social Security Administration and, if necessary, the Department of Homeland Security with information from each new employee's Form I-9 to confirm work authorization.