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How much do downstream scientist jobs pay per hour?

As of Jun 11, 2026, the average hourly pay for downstream scientist in the United States is $41.01, according to ZipRecruiter salary data. Most workers in this role earn between $28.12 and $49.52 per hour, depending on experience, location, and employer.

What is a Downstream Scientist job?

A Downstream Scientist is responsible for the purification and recovery of biological products, such as proteins, antibodies, or viral vectors, after production in upstream processes. They develop and optimize techniques like chromatography, filtration, and centrifugation to ensure product purity and yield. Downstream Scientists work in industries such as biopharmaceuticals, biotechnology, and bioprocessing, often collaborating with upstream teams, analytical scientists, and regulatory professionals. Their role is critical in ensuring that biologic drugs and therapeutics meet quality and regulatory standards for patient use.

What are the key skills and qualifications needed to thrive in the Downstream Scientist position, and why are they important?

To thrive as a Downstream Scientist, you need a solid background in biochemistry, chemical engineering, or related life sciences, with expertise in protein purification, chromatography, and process optimization. Familiarity with laboratory information management systems (LIMS), analytical instruments like HPLC and FPLC, and relevant GMP or GLP certifications is highly valuable. Strong problem-solving skills, attention to detail, teamwork, and effective communication distinguish top performers in this role. These skills are essential for maintaining product quality, meeting regulatory standards, and ensuring smooth collaboration in biopharmaceutical manufacturing environments.

What are the typical challenges faced by Downstream Scientists, and how can they prepare for them?

Downstream Scientists often encounter challenges such as troubleshooting purification processes, optimizing yield and consistency, and meeting stringent regulatory requirements. Adapting to evolving technologies and variable production scales can also be demanding, especially in dynamic biopharmaceutical settings. Gaining hands-on experience with diverse purification methods and staying updated with industry best practices can help you address these challenges effectively. Collaborating closely with upstream and quality assurance teams is also crucial for smooth workflow and continuous improvement.

More about Downstream Scientist jobs
What cities are hiring for Downstream Scientist jobs? Cities with the most Downstream Scientist job openings:
What are the most commonly searched types of Downstream Scientist jobs? The most popular types of Downstream Scientist jobs are:
What states have the most Downstream Scientist jobs? States with the most job openings for Downstream Scientist jobs include:
Infographic showing various Downstream Scientist job openings in the United States as of June 2026, with employment types broken down into 1% As Needed, 95% Full Time, 1% Part Time, and 3% Contract. Highlights an 90% Physical, 3% Hybrid, and 7% Remote job distribution, with an average salary of $85,299 per year, or $41 per hour.
Field Application Scientist, Downstream Bioprocessing (MA)

Field Application Scientist, Downstream Bioprocessing (MA)

Thermo Fisher Scientific

Stoughton, MA

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 14 days ago


Thermo Fisher Scientific rating

7.7

Company rating: 7.7 out of 10

Based on 397 frontline employees who took The Breakroom Quiz

186th of 518 rated manufacturers


Job description

Work Schedule

Standard (Mon-Fri)

Environmental Conditions

Cleanroom: no hair products, jewelry, makeup, nail polish, perfume, exposed piercings, facial hair etc... allowed, Office

Job Description

How You Will Make an Impact

At Thermo Fisher Scientific, our mission is to enable our customers to make the world healthier, cleaner, and safer.

As a Field Application Scientist (FAS) within the BioProduction Group, you will serve as a bioprocessing domain expert—helping biotechnology and biopharmaceutical customers accelerate technology adoption, process design, and optimization across downstream workflows.

You will engage customers on a peer-to-peer, application-focused basis, providing technical leadership and process insight before, during, and after the sale. Acting as both a trusted advisor and problem solver, you will ensure customers achieve compliance, speed, and performance using Thermo Fisher Scientific solutions while helping shape our future innovations through Voice of Customer (VOC) feedback.

Location:

This is a Field application scientist role covering a Massachusetts territory. Residency in MA is required. No relocation assistance provided.

What You Will Do

  • Serve as a technical expert and consultant, applying deep bioprocessing knowledge across purification, filtration and single-use technologies.
  • Engage customers peer-to-peer to support process development, optimization, and technology integration across downstream workflows.
  • Lead pre- and post-sales technical activities, including product evaluations, proof-of-principle (PoP) studies, demos, pilot runs, and technology qualification in regulated environments.
  • Provide comprehensive troubleshooting as the entry point for quality and performance issues, collaborating with Quality, Field Service, and Technical Support to ensure fast, compliant resolution.
  • Deliver technical training for both internal and external audiences—covering process scientists, engineers, and operators—to build capability and confidence in Thermo Fisher systems.
  • Conduct workflow consulting and GEMBA walks at customer sites to identify process improvement opportunities and align solutions with operational goals.
  • Support Bioprocessing Development Center (BDC) activities and on-site demonstrations, ensuring consistent messaging and technical excellence.
  • Develop and implement adoption plans with measurable achievements (e.g., time-to-first-run, time-to-first-GMP lot) and conduct follow-up utilization reviews.
  • Document all activities in CRM/SFDC, maintaining accurate technical engagement records, win plans, and risk mitigation plans.
  • Collaborate cross-functionally with Account Managers, Field Service Engineers, Technical Support, Product Management, R&D, and Quality/Regulatory to deliver seamless end-to-end outcomes.
  • Gather and communicate the Voice of Customer (VOC) to inform product roadmaps, feature development, and best-practice content (application notes, white papers, and case studies).
  • Represent Thermo Fisher Scientific at industry events—including conferences, workshops, and webinars—by delivering workflow-based technical presentations and thought leadership.

How You Will Get There

Education

  • Bachelors degree in Chemical Engineering, Biochemical Engineering, Bioengineering, Biotechnology, or a related discipline (or equivalent bioprocessing experience).
  • Masters degree or PhD highly preferred

Experience

  • 5+ years of hands-on experience in bioprocessing (Process Development, MSAT, or cGMP Manufacturing) with proficiency in at least one of the following:
  • Single-use chromatography systems, and filtration
  • Downstream purification (chromatography, UF/DF)
  • Proven record of technical engagement and process troubleshooting in Process Development and cGMP environments.
  • Experience supporting scale-up, tech transfer, and process optimization projects from development to manufacturing.

Knowledge, Skills, and Abilities

  • Deep understanding of bioprocessing workflows, cGMP principles, and regulatory expectations (FDA, EMA, Annex 1).
  • Ability to interpret URS, P&IDs, batch records, and qualification protocols; comfortable with automation systems and process control HMIs.
  • Skilled in process design, optimization, and workflow consulting, using data-driven analysis to identify improvements.
  • Familiarity with PAT tools , DoE, and QbD principles (ICH Q8/9/10).
  • Knowledge of ASME-BPE standards and risk-based extractables/leachables evaluations for single-use systems.
  • Proficient in data analysis tools (Excel, JMP; scripting a plus) and technical writing.
  • Strong communication, problem-solving, and influencing skills; effective in multi-functional collaboration.
  • Experience using Salesforce.com (SFDC CRM) for opportunity and activity tracking.
  • Demonstrates Thermo Fisher Scientific’s Four I’s values: Integrity, Intensity, Innovation, and Involvement.
  • Ability to commute within the territory up to 75% of the time (3 days out a week) is required.

Our Mission

At Thermo Fisher Scientific, we are driven by our mission to enable our customers to make the world healthier, cleaner, and safer. Join our Bioproduction team and help our customers deliver life-changing medicines through innovation in bioprocessing and technical partnership.

Compensation and Benefits

The salary range estimated for this position based in Massachusetts is $104,000.00–$154,000.00.

This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:

  • A choice of national medical and dental plans, and a national vision plan, including health incentive programs

  • Employee assistance and family support programs, including commuter benefits and tuition reimbursement

  • At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy

  • Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan

  • Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount

For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards


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