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Downstream Scientist Jobs (NOW HIRING)

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Downstream Process Development Scientist - Tech Transfer Consultant

San Carlos, CA · On-site

$75 - $90/hr

  • Retirement

Downstream Process Development Scientist / Tech Transfer Consultant * Employment Type: Contract * Compensation: $75-$90/hour, depending on experience and technical background. * Function: Process ...

Posted today

AIS Inc

Data Scientist

Miami, FL · On-site +1

  • Medical

  • Dental

  • PTO

Generate data products suitable for use by downstream scientific stakeholders (e.g., stock assessment scientists) * Maintain awareness of SEFSC analytical needs and existing workflows to align data ...

AIS Inc

Data Scientist

Miami, FL · Remote

  • Medical

  • Dental

  • PTO

Generate data products suitable for use by downstream scientific stakeholders (e.g., stock assessment scientists) * Maintain awareness of SEFSC analytical needs and existing workflows to align data ...

AIS, Inc.

Data Scientist

Miami, FL · On-site

  • Medical

  • Dental

  • PTO

Generate data products suitable for use by downstream scientific stakeholders (e.g., stock assessment scientists) * Maintain awareness of SEFSC analytical needs and existing workflows to align data ...

Danimer Scientific

Downstream Processing Operator

Winchester, KY · On-site

$16.50 - $20.75/hr

  • Medical

  • Dental

  • Vision

  • Retirement

Downstream Processing (DSP) Operator Winchester, KY | Biodegradable Plastics Schedule: 12 Hour ... Non-exempt | Full-time At Danimer Scientific, we're building the future of sustainable materials ...

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How much do downstream scientist jobs pay per hour?

As of Aug 14, 2026, the average hourly pay for downstream scientist in the United States is $41.01, according to ZipRecruiter salary data. Most workers in this role earn between $28.12 and $49.52 per hour, depending on experience, location, and employer.

What is a downstream scientist?

A Downstream Scientist is responsible for the purification and recovery of biological products, such as proteins, antibodies, or viral vectors, after production in upstream processes. They develop and optimize techniques like chromatography, filtration, and centrifugation to ensure product purity and yield. Downstream Scientists work in industries such as biopharmaceuticals, biotechnology, and bioprocessing, often collaborating with upstream teams, analytical scientists, and regulatory professionals. Their role is critical in ensuring that biologic drugs and therapeutics meet quality and regulatory standards for patient use.

What are the key skills and qualifications needed to thrive as a downstream scientist?

To thrive as a Downstream Scientist, you need a solid background in biochemistry, chemical engineering, or related life sciences, with expertise in protein purification, chromatography, and process optimization. Familiarity with laboratory information management systems (LIMS), analytical instruments like HPLC and FPLC, and relevant GMP or GLP certifications is highly valuable. Strong problem-solving skills, attention to detail, teamwork, and effective communication distinguish top performers in this role. These skills are essential for maintaining product quality, meeting regulatory standards, and ensuring smooth collaboration in biopharmaceutical manufacturing environments.

What are the typical challenges faced by downstream scientists, and how can they prepare for them?

Downstream Scientists often encounter challenges such as troubleshooting purification processes, optimizing yield and consistency, and meeting stringent regulatory requirements. Adapting to evolving technologies and variable production scales can also be demanding, especially in dynamic biopharmaceutical settings. Gaining hands-on experience with diverse purification methods and staying updated with industry best practices can help you address these challenges effectively. Collaborating closely with upstream and quality assurance teams is also crucial for smooth workflow and continuous improvement.

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Downstream Scientist jobs near you
Infographic showing various Downstream Scientist job openings in the United States as of August 2026, with employment types broken down into 1% Internship, 1% As Needed, 87% Full Time, 7% Part Time, and 4% Contract. Highlights an 88% Physical, 3% Hybrid, and 9% Remote job distribution, with an average salary of $85,299 per year, or $41 per hour.

Scientist II, Downstream Viral Vector Process Development

GeneFab

Alameda, CA

$130K - $150K/yr

Full-time

Re-posted 20 days ago

Job description

GeneFab is seeking an experienced Downstream Process Development Scientist/Lead focused on viral vector purification (AAV and Lentiviral) for in vivo gene therapy. It is a technical, project-based role within a CRDMO environment that balances hands-on process optimization with cross-functional leadership and client-facing responsibilities.
 Responsibilities
  • Design, optimize, and scale-up downstream processes for the purification of viral
    vectors, with a focus on in vivo gene therapy products and lentiviral vectors.
  • Execute experimental plans, analyze data, and provide insightful
    recommendations to improve process efficiency, yield, and product quality.
  • Collaborate with cross-functional teams, including Upstream Process
    Development, Analytical Development, and Manufacturing, to ensure seamless
    integration of processes.
  • Troubleshoot and resolve technical challenges in downstream processes, ensuring
    robust and scalable solutions.
  • Present internally and to client with project status updates
  • Stay abreast of industry trends, emerging technologies, and regulatory guidelines
    to contribute to the continuous improvement of processes and compliance.
  • Provide direction and leadership to development associates as the team expands.
Qualifications
  • Ph.D. or Master’s degree in Chemical Engineering, Biochemical Engineering,
    Biotechnology, or related field with a minimum of 3 years (Ph.D.) or 5 years
    (Master’s) of relevant industry experience
  • Proven expertise in downstream process development for viral vectors, with a
    focus on AAV and lentiviral vectors.
  • Hands-on experience with chromatography, filtration, TFF and other downstream
    processing techniques.
  • Strong analytical and problem-solving skills, with the ability to interpret complex
    data sets.
  • Excellent communication skills and the ability to work collaboratively in a team
    environment.
  • Knowledge of regulatory requirements and quality standards related to
    biopharmaceutical manufacturing.
  • Experience with formulation science preferred
About GeneFab 
GeneFab is a contract manufacturing and synthetic biology biofoundry focused on cell and gene therapies. GeneFab was formed in 2023 with a vision to combine industry leading expertise in synthetic biology with advanced cGMP capabilities in order to accelerate the development and commercialization of genetic medicines. GeneFab offers its customers an extensive technology platform and know-how that spans early stage product design, technical development, and cGMP compliant production. GeneFab's technology platform includes bioinformatic-guided discovery of cell type promoters, directed evolution of small molecule-regulated gene switches, and the engineering of highly sensitive kill switches for enhanced safety and control of cellular therapies.

We are committed to an inclusive and diverse GeneFab. We believe that different perspectives lead to better ideas, and better ideas allow us to better understand the needs and interests of our diverse GeneFab team. We welcome people of different backgrounds, experiences, abilities, and perspectives and are an equal opportunity employer.

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.