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Downstream Scientist Jobs (NOW HIRING)

Actalent

Associate Scientist Downstream PD

Boston, MA

$43 - $48/hr

Associate Scientist-Downstream Process Development Join a dynamic and innovative team dedicated to advancing gene therapy processes. This role is perfect for individuals passionate about hands-on ...

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How much do downstream scientist jobs pay per hour?

As of Aug 14, 2026, the average hourly pay for downstream scientist in the United States is $41.01, according to ZipRecruiter salary data. Most workers in this role earn between $28.12 and $49.52 per hour, depending on experience, location, and employer.

What is a downstream scientist?

A Downstream Scientist is responsible for the purification and recovery of biological products, such as proteins, antibodies, or viral vectors, after production in upstream processes. They develop and optimize techniques like chromatography, filtration, and centrifugation to ensure product purity and yield. Downstream Scientists work in industries such as biopharmaceuticals, biotechnology, and bioprocessing, often collaborating with upstream teams, analytical scientists, and regulatory professionals. Their role is critical in ensuring that biologic drugs and therapeutics meet quality and regulatory standards for patient use.

What are the key skills and qualifications needed to thrive as a downstream scientist?

To thrive as a Downstream Scientist, you need a solid background in biochemistry, chemical engineering, or related life sciences, with expertise in protein purification, chromatography, and process optimization. Familiarity with laboratory information management systems (LIMS), analytical instruments like HPLC and FPLC, and relevant GMP or GLP certifications is highly valuable. Strong problem-solving skills, attention to detail, teamwork, and effective communication distinguish top performers in this role. These skills are essential for maintaining product quality, meeting regulatory standards, and ensuring smooth collaboration in biopharmaceutical manufacturing environments.

What are the typical challenges faced by downstream scientists, and how can they prepare for them?

Downstream Scientists often encounter challenges such as troubleshooting purification processes, optimizing yield and consistency, and meeting stringent regulatory requirements. Adapting to evolving technologies and variable production scales can also be demanding, especially in dynamic biopharmaceutical settings. Gaining hands-on experience with diverse purification methods and staying updated with industry best practices can help you address these challenges effectively. Collaborating closely with upstream and quality assurance teams is also crucial for smooth workflow and continuous improvement.

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Downstream Scientist jobs near you
Infographic showing various Downstream Scientist job openings in the United States as of August 2026, with employment types broken down into 1% Internship, 1% As Needed, 87% Full Time, 7% Part Time, and 4% Contract. Highlights an 88% Physical, 3% Hybrid, and 9% Remote job distribution, with an average salary of $85,299 per year, or $41 per hour.

Downstream Manufacturing Scientist

Kashiv Biosciences LLC

Piscataway, NJ • On-site

$95K/yr

Full-time

Re-posted 13 days ago

Job description

Job Type
Full-time
Description
Downstream Manufacturing Scientist (Piscataway, NJ): Perform downstream process at multiple scales in a cGMP environment, column packing, process troubleshooting and data analysis; provide technical direction in the execution and development of the purification process; use programs to collect and evaluate operating data to conduct on- line adjustments to products, instruments, or equipment as well as prepares / reviews all quality management related documents (Deviation / Change control/investigation reports etc.). Base Salary: $95,000 per year.
Requirements
Req's Master's degree (or foreign equivalent degree) in Molecular and Cell Biology or a related field, with knowledge of at least 5 skills from the following list: process development, cGMP Manufacturing MSAT, Bacterial & Mammalian Cell Culture, Depth Filtration, Quality Management Systems, Downstream Purification & Analytical Chromatography.
Apply to HR at Kashiv BioSciences LLC, 20 New England Avenue, Piscataway, NJ 08854.

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