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Downstream Process Jobs in Raleigh, NC (NOW HIRING)

Valspec

CQV Consultant

Holly Springs, NC · On-site

Downstream Processing * CIP (Clean-in-Place) Systems * PSE (Process Support Equipment) * Clean Utilities Key Responsibilities * Execute CQV lifecycle activities including commissioning, IQ/OQ, and ...

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Downstream Process information

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$13

$23

$34

How much do downstream process jobs pay per hour?

As of Jul 9, 2026, the average hourly pay for downstream process in Raleigh, NC is $23.98, according to ZipRecruiter salary data. Most workers in this role earn between $19.18 and $27.36 per hour, depending on experience, location, and employer.

What are some common challenges faced by professionals working in downstream process roles within biomanufacturing?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What are the key skills and qualifications needed to thrive as a Downstream Process Engineer, and why are they important?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What is a Downstream Process in biotechnology?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.
What are popular job titles related to Downstream Process jobs in Raleigh, NC? For Downstream Process jobs in Raleigh, NC, the most frequently searched job titles are:
What job categories do people searching Downstream Process jobs in Raleigh, NC look for? The top searched job categories for Downstream Process jobs in Raleigh, NC are:
What cities near Raleigh, NC are hiring for Downstream Process jobs? Cities near Raleigh, NC with the most Downstream Process job openings:
Downstream Process jobs near you
Infographic showing various Downstream Process job openings in Raleigh, NC as of July 2026, with employment types broken down into 18% Locum Tenens, 69% Full Time, 7% Part Time, 1% Temporary, 4% Contract, and 1% Summer. Highlights an 84% Physical, 5% Hybrid, and 11% Remote job distribution, with an average salary of $49,886 per year, or $24 per hour.
CQV Consultant

CQV Consultant

Valspec

Holly Springs, NC • On-site

Full-time

Medical, Retirement

Re-posted 20 days ago

Job description

Valspec—a global provider of system validation and lifecycle services—provides commissioning and qualification of computerized systems for clients in the Life Sciences industry. Established in 1999, Valspec's mission is to provide a wide spectrum of services that help its clients meet their capital project and lifecycle maintenance goals.

Valspec's projects are critical to the industry, and to the people who rely on its products. Many projects ensure that life-changing drugs are available to those who need them; others streamline production to meet demand at a lower cost, allowing for the discovery of new and innovative therapies.

CQV Consultant – Upstream / Downstream / CIP / PSE / Clean Utilities

Location: Holly Springs (100% Onsite)
Type: Long-Term Contract
Start Date: ASAP

Overview We are seeking experienced CQV Consultants to support a major biopharmaceutical manufacturing project in Holly Springs, NC. This is a long-term onsite opportunity supporting commissioning, qualification, and validation activities across multiple process and utility systems in a GMP manufacturing environment. We are specifically looking for strong "A+" level consultants with hands-on pharmaceutical or biotech project experience supporting large-scale manufacturing operations.

We are hiring CQV professionals with experience in one or more of the following areas:

  • Upstream Processing
  • Downstream Processing
  • CIP (Clean-in-Place) Systems
  • PSE (Process Support Equipment)
  • Clean Utilities

Key Responsibilities

  • Execute CQV lifecycle activities including commissioning, IQ/OQ, and field verification
  • Support startup and qualification of GMP manufacturing equipment and utility systems
  • Author, review, and execute validation documentation and protocols
  • Coordinate with engineering, operations, quality, automation, and project teams
  • Support deviation investigations, change controls, and CAPA activities
  • Ensure compliance with GMP, FDA, and regulatory requirements
  • Participate in walkdowns, system turnover, and punch-list resolution
  • Maintain accurate documentation in accordance with data integrity and quality standards

Qualifications

  • Prior CQV experience in pharmaceutical, biotech, or GMP-regulated manufacturing environments
  • Strong knowledge of commissioning and qualification processes
  • Experience supporting one or more of the following: Upstream, Downstream, CIP, PSE, or Clean Utilities systems
  • Familiarity with GMP documentation practices and regulatory requirements
  • Ability to work onsite in Holly Springs, NC on a full-time basis
  • Strong communication and cross-functional collaboration skills

Preferred Experience

  • Large-scale biologics or vaccine manufacturing projects
  • Startup or greenfield facility experience
  • Experience with DeltaV, MES, or automated process systems
  • Knowledge of clean utilities including WFI, clean steam, compressed gases, and purified water systems

Why Join Valspec?

At Valspec, we offer more than just a job — we provide a career experience rooted in a standout culture, collaborative environment, and a strong sense of ownership. As an Employee Stock Ownership Plan (ESOP) company, every team member has a stake in our success, fostering a shared commitment to excellence and innovation. We also offer a highly competitive benefits package, including:

  • Premium medical coverage
  • 401(k) with company match
  • Tuition reimbursement
  • Unique performance incentives
  • And more — all designed to support your growth, well-being, and future.

Join a team where your contributions matter, your development is prioritized, and your success is shared.

When receiving e-mails from a Proconex or Valspec recruiter, you will only receive e-mails from addresses ending in @proconexdirect.com, @proconex.net or @valspec.net. Any other domains are impersonations and should be ignored.

Candidates must be legally eligible to work in the United States without company sponsorship. Also, we are not interested in working on a corp-to-corp basis with other companies at this time.

Any third-party unsolicited resume submission(s) will immediately become the property of Valspec. Valspec will not pay any fee to a submitting employment agency, person, or entity unless a signed agreement is established.

Valspec is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to sex, race, color, religion, national origin, age, sexual orientation, gender identity, disability, protected veteran status or any other protected class. We are committed to providing a professional environment free of any discrimination or harassment, and we are proud to be a Drug-Free Workplace.