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Downstream Process Jobs in Durham, NC (NOW HIRING)

Amgen SA

Senior Process Engineer

Holly Springs, NC · On-site

$120 - $150/hr

Senior Process Engineer * Provide system ownership for biopharmaceutical process equipment and ... Provide rotational on‑call support to ensure 24/7 reliability of upstream and downstream systems.

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Downstream Process information

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How much do downstream process jobs pay per hour?

As of Aug 22, 2026, the average hourly pay for downstream process in Durham, NC is $23.84, according to ZipRecruiter salary data. Most workers in this role earn between $19.04 and $27.16 per hour, depending on experience, location, and employer.

What is a downstream process?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.

What are the key skills and qualifications needed to thrive as a downstream process engineer?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What are some common challenges faced by professionals working in downstream process roles?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What are popular job titles related to Downstream Process jobs in Durham, NC?

For Downstream Process jobs in Durham, NC, the most frequently searched job titles are:

What job categories do people searching Downstream Process jobs in Durham, NC look for?

The top searched job categories for Downstream Process jobs in Durham, NC are:

What cities near Durham, NC are hiring for Downstream Process jobs?

Cities near Durham, NC with the most Downstream Process job openings:

Downstream Process jobs near you
Infographic showing various Downstream Process job openings in Durham, NC as of August 2026, with employment types broken down into 1% As Needed, 78% Full Time, 16% Part Time, 4% Contract, and 1% Nights. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $49,590 per year, or $23.8 per hour.

Downstream Process Equipment Engineer

Technical Source

Holly Springs, NC • On-site

Contractor

Re-posted 18 days ago

Job description

Technical Source is currently in search of a Downstream Process Engineer for our pharmaceutical client in the Raleigh-Durham-Chapel Hill Area. This is a long-term contract position that requires on-site work. The qualified candidate should have experience supporting the start-up and commissioning of downstream process equipment.

Responsibilities of the Downstream Process Engineer include:

  • P&ID Walkdowns and Redlining
  • Provide Engineering Support to C&Q of Downstream Equipment
  • Troubleshoot Downstream Manufacturing Equipment
  • Interface with Vendors and Relevant Teams
  • Lead Process Improvement Efforts

Qualifications of the Downstream Process Engineer include:

  • Bachelor's Degree in Engineering (Chemical Preferred)
  • 3+ Years of Experience in Process Engineering
  • Experience Working in a Greenfield Environment
  • Extensive Knowledge of Stainless Steel Downstream Equipment

*No C2C or Sponsorship is available at this time*

*Compensation will scale based on experience and fit*