ZipRecruiter

Log In

1

Downstream Process Jobs in Raleigh, NC (NOW HIRING)

Astrix Inc

Manufacturing Associate

Cary, NC · On-site

The ideal candidate holds a BS degree and has hands-on expertise within both upstream and downstream processing. 6 month contract (potential of becoming permanent) Schedule M-F, 8am-4pm Key ...

previous pagenext page

Showing results 21-40

All JobsDownstream Process JobsDownstream Process Jobs in Raleigh, NC

Downstream Process information

See Raleigh, NC salary details

$13

$23

$34

How much do downstream process jobs pay per hour?

As of Aug 22, 2026, the average hourly pay for downstream process in Raleigh, NC is $23.98, according to ZipRecruiter salary data. Most workers in this role earn between $19.18 and $27.36 per hour, depending on experience, location, and employer.

What is a downstream process?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.

What are the key skills and qualifications needed to thrive as a downstream process engineer?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What are some common challenges faced by professionals working in downstream process roles?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What are popular job titles related to Downstream Process jobs in Raleigh, NC?

For Downstream Process jobs in Raleigh, NC, the most frequently searched job titles are:

What job categories do people searching Downstream Process jobs in Raleigh, NC look for?

The top searched job categories for Downstream Process jobs in Raleigh, NC are:

What cities near Raleigh, NC are hiring for Downstream Process jobs?

Cities near Raleigh, NC with the most Downstream Process job openings:

Downstream Process jobs near you
Infographic showing various Downstream Process job openings in Raleigh, NC as of August 2026, with employment types broken down into 1% As Needed, 79% Full Time, 16% Part Time, 3% Contract, and 1% Nights. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $49,886 per year, or $24 per hour.

Manufacturing Associate

Astrix Inc

Cary, NC • On-site

Contractor

Re-posted 15 days ago

Job description

Pay Rate Low: 38 | Pay Rate High: 40
Opportunity to join a cutting edge biotech organization developing innovative gene therapies that enable precise, durable, and scalable treatments for genetic diseases.
We are seeking a motivated Manufacturing Associate with 2+ years of experience in cell and gene therapy production or similar biomanufacturing space. The ideal candidate holds a BS degree and has hands-on expertise within both upstream and downstream processing.
6 month contract (potential of becoming permanent)
Schedule M-F, 8am-4pm
Key Responsibilities:
  • Operate and maintain bioreactors for cell culture and gene therapy manufacturing.
  • Perform downstream purification using AKTA chromatography systems.
  • Monitor process parameters and ensure compliance with SOPs and quality standards.
  • Support batch documentation and data recording.
  • Collaborate with cross-functional teams to optimize manufacturing workflows.
Qualifications:
  • Bachelor's degree in Biotechnology, Biochemistry, or related field.
  • Minimum 2 years' experience in upstream and downstream cell/gene therapy or other related manufacturing.
  • Proficiency with bioreactor operation and AKTA chromatography.
  • Strong attention to detail and adherence to GMP guidelines.
  • Effective communication and teamwork skills.

#LI-ZW1

Apply