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Downstream Process Jobs in Raleigh, NC (NOW HIRING)

BTEC Scientist

Raleigh, NC · On-site

$63K - $88K/yr

We are looking for a self-driven Scientist who thrives in a collaborative team environment and is ready to lead laboratory work, instruct students, and master complex downstream processes. Your daily ...

We are looking for a self-driven Scientist who thrives in a collaborative team environment and is ready to lead laboratory work, instruct students, and master complex downstream processes. Your daily ...

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Downstream Process information

See Raleigh, NC salary details

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$34

How much do downstream process jobs pay per hour?

As of Jul 9, 2026, the average hourly pay for downstream process in Raleigh, NC is $23.98, according to ZipRecruiter salary data. Most workers in this role earn between $19.18 and $27.36 per hour, depending on experience, location, and employer.

What are some common challenges faced by professionals working in downstream process roles within biomanufacturing?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What are the key skills and qualifications needed to thrive as a Downstream Process Engineer, and why are they important?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What is a Downstream Process in biotechnology?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.
What are popular job titles related to Downstream Process jobs in Raleigh, NC? For Downstream Process jobs in Raleigh, NC, the most frequently searched job titles are:
What cities near Raleigh, NC are hiring for Downstream Process jobs? Cities near Raleigh, NC with the most Downstream Process job openings:
Infographic showing various Downstream Process job openings in Raleigh, NC as of July 2026, with employment types broken down into 18% Locum Tenens, 69% Full Time, 7% Part Time, 1% Temporary, 4% Contract, and 1% Summer. Highlights an 84% Physical, 5% Hybrid, and 11% Remote job distribution, with an average salary of $49,886 per year, or $24 per hour.
Technical Sales Specialist, BioProduction Downstream Workflow (South East)

Technical Sales Specialist, BioProduction Downstream Workflow (South East)

Thermo Fisher Scientific

Clayton, NC

$103K - $143K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 26 days ago


Thermo Fisher Scientific rating

7.7

Company rating: 7.7 out of 10

Based on 409 frontline employees who took The Breakroom Quiz

190th of 528 rated manufacturers


Job description

Work Schedule

Standard (Mon-Fri)

Environmental Conditions

Office

Job Description

As part of the Thermo Fisher Scientific team, you’ll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life every single day to enable our customers to make the world healthier, cleaner and safer. We provide our global teams with the resources needed to achieve individual career goals while helping to take science a step beyond by developing solutions for some of the world’s toughest challenges, like protecting the environment, making sure our food is safe or helping find cures for cancer.

Location:

This is a field sales position covering a South East territory. Residency within the territory is required. Preference for residents in Georgia or North Carolina given the concentration of accounts. No relocation assistance is provided.
DESCRIPTION:
Join our collaborative team at Thermo Fisher Scientific as a Senior Product Specialist, where you'll support revenue growth and customer success across our innovative product portfolios. In this role, you'll apply your technical expertise and consultative sales approach to identify opportunities, build strong customer relationships, and deliver solutions that enable groundbreaking scientific advances. Working with cross-functional teams, you'll provide technical leadership in customer engagements, conduct product demonstrations, and serve as a trusted advisor to help customers achieve their research and development goals. Your contributions will directly support our mission of enabling customers to make the world healthier, cleaner, and safer.
REQUIREMENTS:

  • Bachelor's or advanced degree (B.S, M.A, PhD. or equivalent experience) in Chemistry or related field.
  • Experience within Bioproduction is preferred
  • 5 plus years sales experience in biopharmaceutical market required.
  • Demonstrated technical expertise across the downstream bioprocessing workflow, including chromatography resins, process liquids and production solutions, and production chemicals and services supporting biopharmaceutical process development and manufacturing applications
  • Proven ability to build and maintain strong customer relationships through:
  • Developing a comprehensive understanding of customer accounts, manufacturing processes, and stakeholder priorities
  • Assessing and interpreting customer process and operational needs
  • Delivering tailored technical and commercial solutions across the downstream workflow
  • Strong analytical capabilities with experience evaluating:
  • Territory sales performance, market dynamics, and growth opportunities
  • Technical data, manufacturing workflows, and application-specific information
  • Self-motivated professional with the ability to work effectively both independently and within cross-functional and matrixed team environments
  • Established track record of sales success and strategic relationship management within downstream bioprocessing, process development, and biopharmaceutical manufacturing organizations
  • Ability to effectively position integrated downstream solutions spanning chromatography, buffers and process liquids, production chemicals, and manufacturing support services to optimize customer process performance and scalability

Compensation and Benefits

The base salary range estimated for this position based in Georgia- $103,000 -$143,000
- This position is eligible to receive a sales commission based on individual performance in accordance with company policy. We offer a comprehensive Total Rewards package our U.S. colleagues and their families can count on, which includes:
•A choice of national medical and dental plans, and a national vision plan, including health incentive programs
•Employee assistance and family support programs, and tuition reimbursement
•At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy

•Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan

• Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount


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