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Downstream Process Jobs in Ohio (NOW HIRING)

Kelly Services

Chemical Operator

Bowling Green, OH

$24/hr

Pulling of correct raw materials for fermentation * Assist in monitoring of fermentation inventory * Assist in downstream processing of fermentors; (centrifugation, spray drying) * Assist in ...

Kelly Services

Chemical Operator

Bowling Green, OH

$24/hr

Pulling of correct raw materials for fermentation * Assist in monitoring of fermentation inventory * Assist in downstream processing of fermentors; (centrifugation, spray drying) * Assist in ...

Cleveland-Cliffs, Inc.

Process Engineer

Mansfield, OH · On-site

The Company is vertically integrated from the mining of iron ore, production of pellets and direct reduced iron, and processing of ferrous scrap through primary steelmaking and downstream finishing ...

AK Steel

Process Engineer

Mansfield, OH

The Company is vertically integrated from the mining of iron ore, production of pellets and direct reduced iron, and processing of ferrous scrap through primary steelmaking and downstream finishing ...

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Downstream Process information

What are some common challenges faced by professionals working in downstream process roles within biomanufacturing?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What are the key skills and qualifications needed to thrive as a Downstream Process Engineer, and why are they important?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What is a Downstream Process in biotechnology?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.
What are popular job titles related to Downstream Process jobs in Ohio? For Downstream Process jobs in Ohio, the most frequently searched job titles are:
What job categories do people searching Downstream Process jobs in Ohio look for? The top searched job categories for Downstream Process jobs in Ohio are:
What cities in Ohio are hiring for Downstream Process jobs? Cities in Ohio with the most Downstream Process job openings:
Downstream Process jobs near you
Project Manager - Downstream Biologics

Project Manager - Downstream Biologics

Pinnaql

Cincinnati, OH • On-site

Full-time

Posted 16 days ago

Job description

Validation & Engineering Group, Inc. (V&EG) a Pinnaql company is a leading services supplier who provides solutions for the Pharmaceutical, Biotechnology, Chemical, Food, and Medical Devices industries in the following areas: Laboratory, Compliance, Computer, Engineering, Project Management, Validation, and other services.
We are seeking a talented, dedicated individual committed to work under the highest ethics standards for the following position:
  • Project Manager - Downstream Biologics

Description:
Leads capital projects within downstream biologics manufacturing, supporting capacity expansion and facility enhancements within existing operations. Manages projects through the full project lifecycle from concept through engineering, construction, and CQV, ensuring alignment with business and site objectives.
Responsibilities:
  • Lead capital projects from initiation through design, construction, and CQV completion.
  • Manage projects related to downstream biologics processes, including fill/finish, cell culture, reactors, and related systems.
  • Drive capacity expansion initiatives within existing manufacturing facilities.
  • Coordinate cross-functional teams including Engineering, Site Operations, and CQV stakeholders.
  • Present project updates, project status, and key decisions to Global Engineering leadership and site executives.
  • Ensure adherence to scope, schedule, cost, and quality objectives.
  • Manage project execution to support business goals and site operational requirements.
  • Facilitate communication and collaboration across project teams and stakeholders.
  • Support project planning, risk management, and decision-making throughout the project lifecycle.

Qualifications:
  • Experience leading capital projects within pharmaceutical, biotechnology, or biologics manufacturing environments.
  • Strong knowledge of downstream biologics manufacturing processes, including fill/finish, cell culture, reactors, and associated process systems.
  • Experience managing projects through engineering, construction, commissioning, qualification, and validation (CQV) phases.
  • Experience supporting manufacturing capacity expansion projects within existing operating facilities.
  • Strong project management skills with demonstrated ability to manage scope, schedule, cost, and quality objectives.
  • Experience leading cross-functional teams and coordinating multiple stakeholders.
  • Strong leadership, communication, and presentation skills.
  • Ability to present project updates and strategic recommendations to senior leadership and executive stakeholders.
  • Strong organizational, analytical, and problem-solving skills.
  • Ability to manage multiple priorities in a fast-paced project environment.
  • Available to work extended hours, possibility of weekends and holidays.

At Validation & Engineering Group, people always come first. We believe that when you're empowered to do your best work, bold ideas thrive and real progress happens. This isn't just a job - it's an opportunity to make a meaningful difference by shaping the future of healthcare and technology alongside a purpose-driven, supportive team.
Excited to build something meaningful together? We look forward to hearing from you.
Validation & Engineering Group is an equal opportunity employer. All applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran status, or disability status.

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