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Downstream Process Jobs in Ohio (NOW HIRING)

Kelly Services

Chemical Operator

Bowling Green, OH

$24/hr

Pulling of correct raw materials for fermentation * Assist in monitoring of fermentation inventory * Assist in downstream processing of fermentors; (centrifugation, spray drying) * Assist in ...

Cleveland-Cliffs, Inc.

Process Engineer

Mansfield, OH · On-site

The Company is vertically integrated from the mining of iron ore, production of pellets and direct reduced iron, and processing of ferrous scrap through primary steelmaking and downstream finishing ...

AK Steel

Process Engineer

Mansfield, OH

The Company is vertically integrated from the mining of iron ore, production of pellets and direct reduced iron, and processing of ferrous scrap through primary steelmaking and downstream finishing ...

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Downstream Process information

What are some common challenges faced by professionals working in downstream process roles within biomanufacturing?

Professionals in downstream process roles often encounter challenges such as optimizing purification steps to maximize yield and product purity while minimizing costs and processing time. They must also troubleshoot issues related to equipment performance, scalability, and regulatory compliance, especially when transitioning from lab-scale to large-scale production. Collaboration with upstream teams, quality assurance, and engineering is critical to address these challenges and ensure a smooth workflow. Staying current with technological advances and regulatory requirements also plays a significant role in day-to-day success.

What are the key skills and qualifications needed to thrive as a Downstream Process Engineer, and why are they important?

To thrive as a Downstream Process Engineer, you need a solid background in chemical or biochemical engineering, knowledge of purification techniques, and typically a relevant degree. Familiarity with process control systems, chromatography, filtration technologies, and GMP compliance, as well as certifications like Six Sigma, are commonly required. Strong problem-solving, teamwork, and communication skills help you excel in cross-functional teams and address complex production challenges. These skills ensure efficient, high-quality product recovery and compliance with industry standards in biomanufacturing environments.

What is the difference between Downstream Process vs Upstream Process?

AspectDownstream ProcessUpstream Process
PurposePurifies and isolates the target product from the mixtureProduces the initial product, such as cell culture or fermentation
ActivitiesFiltration, chromatography, centrifugation, purificationCell growth, fermentation, media preparation
Work EnvironmentLaboratories, bioprocessing facilitiesBioreactors, fermentation tanks, labs
Required SkillsBioprocessing techniques, chromatography, filtrationMicrobiology, cell culture, fermentation technology

Downstream Process focuses on purifying the product, while Upstream Process involves producing the raw material. Both are essential steps in biopharmaceutical manufacturing, often working sequentially to ensure high-quality product output.

What is a Downstream Process in biotechnology?

A Downstream Process refers to the series of steps involved in the purification and recovery of biological products, such as proteins, enzymes, or antibodies, after they have been produced by microorganisms or cells during fermentation or cell culture. It typically includes cell separation, product isolation, purification, and polishing to achieve the desired product quality and purity. Downstream processing is crucial for ensuring that biopharmaceutical products meet regulatory and safety standards before they reach the market.
What are popular job titles related to Downstream Process jobs in Ohio? For Downstream Process jobs in Ohio, the most frequently searched job titles are:
What job categories do people searching Downstream Process jobs in Ohio look for? The top searched job categories for Downstream Process jobs in Ohio are:
What cities in Ohio are hiring for Downstream Process jobs? Cities in Ohio with the most Downstream Process job openings:
Downstream Process jobs near you
Production Technician (Bioprocessing)

Production Technician (Bioprocessing)

Kelly Services

Bowling Green, OH • On-site

$24/hr

Full-time

Medical, Dental, Vision, Life, Retirement

Posted 19 hours ago

Job description

Production Technician (Bioprocessing)
Work Schedule: 2nd Shift; 3pm-11pm
Location: Bowling Green, OH
Job Status: Direct Hire/Full Benefits
Salary: $24 per hour with potential pay increases
The Production Technician (Bioprocessing) will be responsible for the manufacturing of microbial products, monitoring  the downstream process of the fermenters.
Job Responsibilities: other duties may be assigned as needed.
  • Ensure standard operating procedures are followed and reviewed
  • Ensure batch records are completed
  • Pulling of correct raw materials for fermentation
  • Assist in monitoring of fermentation inventory
  • Assist in downstream processing of fermentors; (centrifugation, spray drying)
  • Assist in preventative maintenance of fermentation equipment
  • Ensure department is clean and organized at all times and free of hazards and safety violations
  • Operation of forklifts as required
  • Batching of media for fermentation runs
  • SIP, CIP of fermentors
  • Work odd shifts as required
  • Labeling of fermentation vessel pipes and valves
  • Participate in safety training programs
  • Monitoring of in process fermentation
  • Assist with microscopic observation of bacteria example: harvest of batch
  • Ensuring fermentation equipment is labelled
  • Using of the autoclave for fermentation addition bottles example: acid, base, defoamer bottles
  • Assist in the training of new technicians
  • Strong knowledge of pressure vessels
  • Strong knowledge of pump and pumping operations
  • The ability to identify different types of valves and how they operate, (both pneumatic and hand valves)
  • Strong trouble shooting skills in both mechanical and electrical applications
  • Basic sampling skills
  • Chemical Operator experience preferred
  • Preferred confined space, lock out tag out training
  • Experience working with boilers a plus
  • Experience working with PLC's and HMI a plus
Job Requirements:
  • High School Diploma or Equivalent
  • Proficient with Microsoft Word and Outlook
  • Must be able to lift up to 50lbs.
  • Ability to work odd shift and Overtime as needed
For immediate consideration, please forward your updated resume.
 
As part of our promise to talent, Kelly supports those who work with us through a variety of benefits, perks, and work-related resources. Kelly offers eligible employees voluntary benefit plans including medical, dental, vision, telemedicine, term life, whole life, accident insurance, critical illness, a legal plan, and short-term disability. As a Kelly employee, you will have access to a retirement savings plan, service bonus and holiday pay plans (earn up to eight paid holidays per benefit year), and a transit spending account. In addition, employees are entitled to earn paid sick leave under the applicable state or local plan. Click here for more information on benefits and perks that may be available to you as a member of the Kelly Talent Community.

Why Kelly® Science & Clinical?

Kelly Science & Clinical is your connection to premier scientific and clinical companies looking to hire industry experts just like you. Our team creates expert talent solutions to solve the world’s most critical challenges. Every day, we match science professionals with dream jobs that fit their skills, interests, and career goals-it’s the way we think job searching should be. Nearly 100 percent of our science recruiters have a professional background and education in science, so we know a thing or two about the science market and how to get your expertise noticed.

About Kelly

Work changes everything. And at Kelly, we’re obsessed with where it can take you. To us, it’s about more than simply accepting your next job opportunity. It’s the fuel that powers every next step of your life. It’s the ripple effect that changes and improves everything for your family, your community, and the world. Which is why, here at Kelly, we are dedicated to providing you with limitless opportunities to enrich your life-just ask the 300,000 people we employ each year.
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