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Director Trial Master File Jobs (NOW HIRING)

GQR

Associate Director TMF

Hayward, CA · On-site

$165K - $200K/yr

About the Company A Clinical-Stage Biotech advancing a cardiometabolic pipeline toward pivotal trials is hiring its Associate Director, Trial Master File. About the Role You will own TMF strategy ...

GQR

Associate Director TMF

San Mateo, CA · On-site

$165K - $200K/yr

About the Company A Clinical-Stage Biotech advancing a cardiometabolic pipeline toward pivotal trials is hiring its Associate Director, Trial Master File. About the Role You will own TMF strategy ...

GQR

Associate Director TMF

Fremont, CA · On-site

$165K - $200K/yr

About the Company A Clinical-Stage Biotech advancing a cardiometabolic pipeline toward pivotal trials is hiring its Associate Director, Trial Master File. About the Role You will own TMF strategy ...

GQR

Associate Director TMF

Sunnyvale, CA · On-site

$165K - $200K/yr

About the Company A Clinical-Stage Biotech advancing a cardiometabolic pipeline toward pivotal trials is hiring its Associate Director, Trial Master File. About the Role You will own TMF strategy ...

GQR

Associate Director TMF

Mundelein, IL · On-site

$165K - $200K/yr

About the Company A Clinical-Stage Biotech advancing a cardiometabolic pipeline toward pivotal trials is hiring its Associate Director, Trial Master File. About the Role You will own TMF strategy ...

GQR

Associate Director TMF

Santa Clara, CA · On-site

$165K - $200K/yr

About the Company A Clinical-Stage Biotech advancing a cardiometabolic pipeline toward pivotal trials is hiring its Associate Director, Trial Master File. About the Role You will own TMF strategy ...

GQR

Associate Director TMF

San Jose, CA · On-site

$165K - $200K/yr

About the Company A Clinical-Stage Biotech advancing a cardiometabolic pipeline toward pivotal trials is hiring its Associate Director, Trial Master File. About the Role You will own TMF strategy ...

GQR

Associate Director TMF

San Francisco, CA · On-site

$165K - $200K/yr

About the Company A Clinical-Stage Biotech advancing a cardiometabolic pipeline toward pivotal trials is hiring its Associate Director, Trial Master File. About the Role You will own TMF strategy ...

GQR

Associate Director TMF

Sonoma, CA · On-site

$165K - $200K/yr

About the Company A Clinical-Stage Biotech advancing a cardiometabolic pipeline toward pivotal trials is hiring its Associate Director, Trial Master File. About the Role You will own TMF strategy ...

GQR

Associate Director TMF

Alameda, CA · On-site

$165K - $200K/yr

About the Company A Clinical-Stage Biotech advancing a cardiometabolic pipeline toward pivotal trials is hiring its Associate Director, Trial Master File. About the Role You will own TMF strategy ...

GQR

Associate Director TMF

Santa Rosa, CA · On-site

$165K - $200K/yr

About the Company A Clinical-Stage Biotech advancing a cardiometabolic pipeline toward pivotal trials is hiring its Associate Director, Trial Master File. About the Role You will own TMF strategy ...

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All JobsDirector Trial Master File Jobs

Director Trial Master File information

See salary details

$45K

$128.4K

$232.5K

How much do director trial master file jobs pay per year?

As of Jun 23, 2026, the average yearly pay for director trial master file in the United States is $128,367.00, according to ZipRecruiter salary data. Most workers in this role earn between $58,000.00 and $188,500.00 per year, depending on experience, location, and employer.

What is the difference between Director Trial Master File vs Clinical Trial Coordinator?

AspectDirector Trial Master FileClinical Trial Coordinator
CredentialsAdvanced degrees (e.g., Life Sciences, Healthcare), experience in clinical trial documentationBachelor's degree, certification in clinical research preferred
Work EnvironmentSenior management, overseeing TMF processes across projectsOperational role, supporting trial activities at site or sponsor level
Industry UsageUsed in pharmaceutical, biotech, and CRO settings for document oversightCommonly employed in clinical sites and research organizations

The Director Trial Master File focuses on strategic oversight and management of trial documentation, ensuring compliance and quality. In contrast, the Clinical Trial Coordinator handles day-to-day trial activities, including document collection and site coordination. Both roles are essential but differ in scope, responsibilities, and seniority within the clinical research process.

What are the key skills and qualifications needed to thrive as a Director Trial Master File, and why are they important?

To thrive as a Director Trial Master File, you need deep knowledge of clinical trial processes, regulatory guidelines (such as GCP and ICH), and extensive experience in TMF management, often supported by a relevant degree and prior leadership in clinical operations. Expertise with electronic Trial Master File (eTMF) systems, document management platforms, and familiarity with industry certifications like DIA TMF Practitioner are highly valued. Strong leadership, attention to detail, and excellent communication skills distinguish top performers in this role. These capabilities ensure regulatory compliance, audit readiness, and effective oversight of clinical trial documentation, which are critical for successful drug development.

What are some common challenges a Director of Trial Master File faces when ensuring TMF completeness and inspection readiness?

A Director of Trial Master File often encounters challenges related to maintaining TMF completeness across multiple studies and vendors, ensuring timely document submission, and preparing for regulatory inspections. Coordinating efforts among cross-functional teams—including clinical operations, regulatory affairs, and external partners—can be complex, especially when aligning on documentation standards and resolving discrepancies. Proactive communication, robust quality control processes, and familiarity with evolving regulatory requirements are key to overcoming these challenges and ensuring inspection readiness.

What are Director Trial Master File roles and responsibilities?

A Director of Trial Master File (TMF) oversees the management and quality of TMF systems, which are essential for documenting the conduct of clinical trials. They ensure that all trial documentation is complete, accurate, and compliant with regulatory requirements. This role involves developing TMF strategies, leading teams, implementing best practices, and collaborating with clinical, regulatory, and quality assurance departments to support clinical trial audits and inspections. The director also manages TMF vendors, monitors key performance indicators, and drives process improvements.
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Director Trial Master File jobs near you
Infographic showing various Director Trial Master File job openings in the United States as of June 2026, with employment types broken down into 100% Full Time. Highlights an 78% In-person, and 22% Remote job distribution, with an average salary of $128,367 per year, or $61.7 per hour.
Trial Master File [TMF] Administrator

Trial Master File [TMF] Administrator

Medpace, Inc.

Cincinnati, OH • On-site

$32.25 - $44/hr

Other

Medical, PTO

Posted 9 days ago

Medpace rating

8.4

Company rating: 8.4 out of 10

Based on 8 frontline employees who took The Breakroom Quiz

15th of 57 rated research

Job description

Job Summary

We are currently hiring individuals seeking an exciting career in clinical research, managing our Trial Master File. The Trial Master File (TMF) is a collection of documents that stores all data and research collected on a given trial. The TMF allows us to conduct a clinical trial and ensures data integrity. It is an integral tool and helps teams manage trials more effectively. TMF oversight is important to the successful execution of a trial and ultimately plays a big role in a new drug or device receiving approval by the FDA. In this position, you will be working with a highly experienced team of other administrators and clinical research professionals that can help you grow your skillset while working for a growing and developing company. *This position is fully office-based in Cincinnati, OH. 

Responsibilities

The Clinical Records Administrator supports TMF oversight for a trial by ensuring documents meet established quality standards. This role appeals to those with a methodical and curious mind. It requires both independent and computer-based work, as well as frequent communication and collaboration with trial teams.

  • Manage electronic filing system for trial documentation;
  • Track, maintain, and perform quality check of electronic documents;
  • Communicate with internal associates globally regarding the TMF; and
  • Prepare documents for shipment
Qualifications
  • Associates degree, or equivalent;
  • Experience in document administration;
  • High attention to detail;
  • Exemplary organizational skills
  • Strong written and verbal communication skills; and
  • Knowledge of MS Office (Excel and Outlook)
Medpace Overview

Medpace is a full-service clinical contract research organization (CRO). We provide Phase I-IV clinical development services to the biotechnology, pharmaceutical and medical device industries. Our mission is to accelerate the global development of safe and effective medical therapeutics through its scientific and disciplined approach. We leverage local regulatory and therapeutic expertise across all major areas including oncology, cardiology, metabolic disease, endocrinology, central nervous system, anti-viral and anti-infective. Headquartered in Cincinnati, Ohio, employing more than 6,000 people across 40+ countries.

Why Medpace?

People. Purpose. Passion. Make a Difference Tomorrow. Join Us Today.

The work we've done over the past 30+ years has positively impacted the lives of countless patients and families who face hundreds of diseases across all key therapeutic areas. The work we do today will improve the lives of people living with illness and disease in the future.

Cincinnati Perks

  • Cincinnati Campus Overview
  • Flexible work environment
  • Competitive PTO packages, starting at 20+ days
  • Competitive compensation and benefits package
  • Company-sponsored employee appreciation events
  • Employee health and wellness initiatives
  • Community involvement with local nonprofit organizations
  • Discounts on local sports games, fitness gyms and attractions
  • Modern, ecofriendly campus with an on-site fitness center
  • Structured career paths with opportunities for professional growth
  • Discounted tuition for UC online programs

Awards

  • Named a Top Workplace in 2024 by The Cincinnati Enquirer

  • Recognized by Forbes as one of America's Most Successful Midsize Companies in 2021, 2022, 2023 and 2024
  • Continually recognized with CRO Leadership Awards from Life Science Leader magazine based on expertise, quality, capabilities, reliability, and compatibility

What to Expect Next

A Medpace team member will review your qualifications and, if interested, you will be contacted with details for next steps.

Employment Type: OTHER
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About Medpace

Sourced by ZipRecruiter

Medpace is a globally recognized clinicial contract research organization (CRO) based in Cincinnati, OH, in the United States. Established in 1992, it operates in the healthcare sector, providing scientifically-driven outsourcing solutions for the development of drugs and medical devices. It offers comprehensive services like full-service clinical development services, regulatory affairs management, clinical pharmacology, data management, statistical analysis, and medical writing. By applying a scientifically-driven, therapeutically-focused, and patient-centric approach, Medpace's mission is to accelerate the global development of safe and effective medical therapies.

Industry

Medical equipment and supplies manufacturing

Company size

1,001 - 5,000 Employees

Headquarters location

Cincinnati, OH, US

Year founded

1992

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