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Director Biophysics Jobs (NOW HIRING)

AbbVie

Associate Director, Technical PDS&T

Irvine, CA · On-site

... the Director, PDS&T Toxins. Responsibilities: * Manage the protein characterization group by ... In-depth expertise of a broad range of biological, biochemical and biophysical methods for biologic ...

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Director Biophysics information

What are the key skills and qualifications needed to thrive as a Director of Biophysics, and why are they important?

To thrive as a Director of Biophysics, you need a Ph.D. in biophysics or a related field, extensive research experience, and strong leadership capabilities. Expertise with advanced biophysical instrumentation, data analysis software, and familiarity with regulatory and laboratory compliance systems is crucial. Strong communication, strategic thinking, and team management skills set outstanding candidates apart in this role. These abilities are vital for guiding research direction, ensuring high-quality scientific output, and fostering collaboration across multidisciplinary teams.

How does a Director of Biophysics typically collaborate with cross-functional teams in pharmaceutical research and development?

A Director of Biophysics frequently partners with teams such as medicinal chemistry, structural biology, and computational biology to drive drug discovery projects forward. They play a pivotal role in translating complex biophysical data into actionable insights for project teams and often lead the design of experimental strategies to address key scientific questions. Effective communication and leadership are essential, as the director must ensure alignment between diverse scientific groups and help prioritize resources and timelines. Regular cross-departmental meetings and project reviews are common to maintain progress and foster innovation.

What does a Director of Biophysics do?

A Director of Biophysics leads and manages research teams focused on understanding the physical principles underlying biological systems. They are responsible for designing and overseeing experiments, developing innovative research strategies, and ensuring that projects align with organizational goals. This role often involves collaborating with scientists across disciplines, managing resources and budgets, and communicating findings to stakeholders. Directors of Biophysics play a crucial role in advancing scientific knowledge and developing new technologies in areas like drug discovery, medical devices, and biotechnology.

What is the difference between Director Biophysics vs Research Scientist Biophysics?

AspectDirector BiophysicsResearch Scientist Biophysics
Required CredentialsPhD in Biophysics or related field, extensive experienceMaster's or PhD, focus on research
Work EnvironmentLeadership role, strategic planning, team managementLaboratory research, experimental work
Employer & Industry UsageBiotech, pharmaceutical companies, research institutionsAcademic labs, research institutions, industry R&D
Common Search & ComparisonLeadership, management, strategic oversightResearch, experimental techniques, data analysis

The main difference between a Director Biophysics and a Research Scientist Biophysics lies in their roles and responsibilities. The Director typically oversees research programs, manages teams, and sets strategic goals, while the Research Scientist focuses on conducting experiments and analyzing data. Both roles require advanced degrees and experience, but the Director's position emphasizes leadership and management within the biophysics field.

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Director Biophysics jobs near you
Infographic showing various Director Biophysics job openings in the United States as of May 2026, with employment types broken down into 77% Full Time, 8% Part Time, and 15% Contract. Highlights an 100% In-person job distribution.
Director/Senior Director, Antibody Discovery

Director/Senior Director, Antibody Discovery

BigHat Biosciences

San Mateo, CA

$230K - $270K/yr

Full-time

Medical, Dental, Vision, Retirement

Posted 15 days ago

Job description

Description
The Role: BigHat is seeking an exceptional and highly experienced individual for a position as Director/Senior Director of Antibody Discovery. This individual will lead the company’s antibody discovery and display function. They will be responsible for conceiving of and leading multi-year team and technology strategy as well as managing routine operational execution for identification and maturation of high-quality antibodies across antigen types for both BigHat and BigHat-partnered therapeutic research programs.

Key Responsibilities
  • Lead BigHat’s antibody discovery and display functions, setting the scientific, technical, and strategic direction 
  • Oversee the routine execution of display-based selection campaigns to enhance and diversify affinity, developability, and function across diverse antibody formats and antigen types in support of BigHat and BigHat-partnered therapeutic programs
  • Manage and mentor a team of scientists responsible for antibody library design, generation, screening, selection, and early optimization
  • Shape and expand BigHat’s antibody discovery technologies and capabilities, including new display and selection methods, library design strategies, and technical approaches that leverage and enhance the company’s integrated experimental and computational platform
  • Provide scientific leadership across discovery and early optimization efforts, ensuring antibodies emerging from selections possess strong functional and developability characteristics
  • Work closely with leaders in Protein Sciences, Data Science/Machine Learning, Engineering, and Platform groups to ensure seamless progression from discovery through characterization and optimization
  • Collaborate with biology and therapeutic research leads to ensure display outputs align with and advance program objectives
  • Foster a collaborative and high-performance culture within the discovery organization

Skills Knowledge and Expertise
  • Ph.D. in molecular biology, biochemistry, protein engineering, or related discipline with 12+ years of experience in antibody discovery and engineering within academia, biotechnology, or pharmaceutical industries
  • 8+ years of managerial experience leading scientific teams
  • Strong expertise with protein display systems such as yeast, phage, mammalian, or mRNA display
  • Demonstrated experience with antibody library design, construction, screening, and selection analysis
  • Deep understanding of antibody structure-function relationships and mechanisms of antigen recognition
  • Experience integrating antibody discovery workflows with downstream characterization and developability assessment, including functional screening and biophysical evaluation of antibody candidates
  • Familiarity with computational or ML-enabled approaches to protein design and optimization
  • Experience advancing biologics from early discovery through lead optimization stages
  • Knowledge of diverse antibody modalities including multispecific antibodies, antibody fragments, and other advanced formats
  • Strong leadership skills with experience building and mentoring scientific teams
  • Strategic thinker capable of aligning discovery activities with broader company goals
  • Excellent communication and cross-functional collaboration skills
  • Self-motivated and comfortable working in a fast-paced startup environment
  • Must be willing to work onsite 5 days per week

Total Rewards
The salary estimated for this position is $230,000 - $270,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.
What BigHat Offers:
  • Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
  • Dental, and vision coverage through Guardian
  • Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
  • 401(k) with company match 
  • DTO, two weeks of company-wide shutdown, and 12 company holidays
  • Paid parental leave