Digital Transformation Director Jobs in Reston, VA

Job Summary:

TheDirector, GTO Digital Initiativesleads the day-to-day delivery of priority digital transformation initiatives within the GTO digital portfolio. This role converts portfolio priorities into executable delivery plans, coordinates matrixed contributors, strengthens governance and delivery field, and provides portfolio management support to the Senior Director, GTO Digital Transformation.

The initial anchor program for this role is theBiologics workstream within the OPS2030 Digital Tech Transfer initiative, including associated pilots and scale-readiness activities. Over time, the role may also support other GTO digital initiatives requiring senior delivery leadership, transformation field, and cross-functional coordination.

Key Responsibilities:

Digital Initiative Delivery

• Lead delivery execution:Lead day-to-day delivery of assigned GTO digital initiatives, beginning with the Biologics Digital Tech Transfer workstream and growing to other priority initiatives as portfolio needs evolve.
• Manage pilots and workstreams:Own planning, execution, achievement tracking, risk management, dependency management, and readiness for scale for assigned pilots and workstreams.
• Translate strategy into execution:Convert priorities established by the Senior Director and governance teams into executable delivery plans, achievements, decision points, and blocking issue pathways.
• Represent Biologics requirements:Ensure Biologics requirements are represented across Development, Commercial, Alexion, and site perspectives for the initial DTT anchor program.
• Coordinate enabling partners:Partner with Data, Architecture, IT, PMO, Enterprise Data Office, and other capability teams to support foundations, domain models, semantic layers, integrations, and governance needs.

Portfolio Management Support:

• Maintain portfolio tracking:Manage portfolio tracking, delivery cadence, status reporting, dependency views, and governance materials on behalf of the Senior Director.
• Prepare governance updates:Develop clear program and governance updates that proactively surface risks, blockers, decision needs, and resource gaps.
• Support intake and roadmap hygiene:Maintain intake subject area and roadmap updates while recognizing that prioritization, scope approval, and trade-off decisions remain with the Senior Director.

Financial and Delivery Management

• Track initiative financials:Own forecast versus actual spend, accruals, cross-charges, vendor and purchase order status, and budget risks for assigned initiatives and workstreams.
• Track delivery performance:Maintain project and task tracking for breakthroughs, risks, actions, dependencies, resource demand, and delivery readiness.
• Provide regular reporting:Report financial and delivery status on a defined cadence without requiring repeated follow-up.

Transformation and Future-State Build

• Drive process re imagination:Advance simplification, automation, AI-enabled workflows, knowledge retention, and scalable future-state ways of working.
• Translate concepts into delivery:Convert transformation opportunities into pilots, use cases, business capabilities, delivery plans, and measurable outcomes.
• Challenge status quo:Help move programs beyond simple digitization toward redesigned, data-enabled, and AI-ready tech transfer processes.

Minimum Qualifications

• Bachelor's degreein Engineering, Life Sciences, Pharmaceutical Sciences, Biotechnology, Information Systems, Data Science, Business, or a related field.

• Minimum 10+ years of experience
• Demonstrated experience in pharmaceutical, biotechnology, manufacturing, technical operations, digital transformation, program delivery, or related areas.
• Demonstrated experience leadingcomplex, matrixed digital transformation programsin manufacturing, technical operations, tech transfer, process development, MS&T, quality, data, or other regulated environments.
• Strongprogram and project managementcapabilities with the ability to lead teams and workstreams without direct line authority.
• Strongfinancial management skills, including experience with forecasts, actual spend, accruals, vendor status, purchase orders, cross-charges, and delivery tracking.
• Understanding oftechnical operations and digital transformation in regulated environments.
• Strongcustomer management, facilitation, executive communication, risk management, and escalationskills.
• Collaborative, low-ego operating style with the ability to work effectively within a defined role scope while providing senior delivery leadership.

Preferred Qualifications

• Advanced degreesuch as MBA, MS, PhD, PharmD, or equivalent experience.
• Experience inBiologics tech transfer lifecycle, including drug substance, drug product, analytical, manufacturing readiness, and quality/regulatory considerations.
• Experience withenterprise data strategy, domain modeling, semantic technologies, ontologies, data governance, knowledge management, or digital manufacturing platforms.
• Experience withAI, GenAI, analytics, automation, digital manufacturing, or Industry 4.0 initiativesin regulated environments.
• Experience partnering withPMO, Enterprise Data, Architecture, IT, consulting partners, and cross-functional business teams.

Success Measures

• Assigned digital initiatives are delivered with clear ownership, governance, cadence, risk management, and readiness for scale.
• Biologics requirements are consistently represented across Development, Commercial, Alexion, site, data, architecture, and enterprise program forums.
• Spend, resource demand, vendor and purchase order status, milestones, risks, and dependencies are proactively tracked and reported.
• Sponsor capacity is increased by shifting day-to-day delivery leadership for assigned initiatives to this role while strategic and enterprise accountability remains with the Senior Director.
• Programs advance beyond status-quo digitization toward simplified, data-enabled, and AI-ready future-state tech transfer processes.

When we put unexpected teams in the same room, we unleash bold thinking with the power to encourage life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

The annual base pay for this position ranges from $172,466.40 - $258,699.60 USD Annual. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Are you ready to bring new insights and fresh thinking to the table?Fantastic! We have one seat available, and we hope it's yours. Apply today.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

Date Posted

30-Jul-2026

Closing Date

11-Aug-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.