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Computer Informatics Jobs in California (NOW HIRING)

Astrana Health, Inc.

$103K - $170K/yr

Clinical Informatics Analyst Department: 8610-Hospital Admin Employment Type: Full Time Location ... Work As One Team What You'll Do Builds, tests, implements, and supports computer applications and ...

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All JobsComputer Informatics JobsComputer Informatics Jobs in California

Computer Informatics information

See California salary details

$41.9K

$84.5K

$123.4K

How much do computer informatics jobs pay per year?

As of Aug 16, 2026, the average yearly pay for computer informatics in California is $84,488.00, according to ZipRecruiter salary data. Most workers in this role earn between $68,100.00 and $98,700.00 per year, depending on experience, location, and employer.

What are some common challenges faced by professionals in computer informatics and how can they be addressed?

Professionals in Computer Informatics often encounter challenges such as managing large volumes of data, ensuring data security, and integrating new technologies into existing systems. Staying current with rapidly evolving tools and best practices is essential, as is effective communication with multidisciplinary teams. To address these challenges, it's helpful to continuously update technical skills, participate in cross-functional meetings, and leverage collaboration tools to streamline workflows and maintain data integrity.

What is the difference between Computer Informatics vs Computer Science?

AspectComputer InformaticsComputer Science
Required CredentialsBachelor's degree in Computer Informatics or related fieldBachelor's or higher in Computer Science or related field
Work EnvironmentHealthcare, business, and technology sectors focusing on information systemsResearch, software development, and algorithm design in various industries
Employer & Industry UsageHospitals, healthcare organizations, and tech companiesTech firms, academia, research labs, and software companies
Common Search & Comparison IntentUnderstanding career paths, job roles, and skillsExploring technical depth, programming, and research opportunities

Computer Informatics focuses on applying information technology in practical settings like healthcare and business, emphasizing systems and data management. In contrast, Computer Science is more research-oriented, emphasizing algorithms, programming, and theoretical foundations. Both fields share similar credentials but serve different industry needs and career paths.

What is computer informatics?

Computer Informatics is the study and practice of collecting, processing, storing, and retrieving information using computer systems and technology. It combines aspects of computer science, information technology, and data management to solve problems and improve decision-making in various fields. Professionals in computer informatics work with databases, networks, software development, and data analysis to optimize the use of information within organizations. The field is essential in industries such as healthcare, business, education, and government, where efficient and secure information management is critical.

Is computer informatics still in demand?

Computer informatics is a growing field with strong demand due to increasing reliance on data management, healthcare technology, and information systems. Professionals with skills in data analysis, programming, and health informatics are sought after across various industries, including healthcare, finance, and technology sectors.

What are the key skills and qualifications needed to thrive as a computer informatics professional?

To thrive as a Computer Informatics professional, you need a solid background in information systems, programming, data analysis, and database management, often supported by a relevant degree. Familiarity with SQL, Python or Java, data visualization tools, and certifications like CompTIA ITF+ or Certified Information Systems Security Professional (CISSP) are highly valuable. Strong analytical thinking, problem-solving abilities, and effective communication set top performers apart in this field. These skills and qualifications are crucial for developing, managing, and securing information systems that support organizational decision-making and operations.

What are popular job titles related to Computer Informatics jobs in California?

For Computer Informatics jobs in California, the most frequently searched job titles are:

What job categories do people searching Computer Informatics jobs in California look for?

The top searched job categories for Computer Informatics jobs in California are:

What cities in California are hiring for Computer Informatics jobs?

Cities in California with the most Computer Informatics job openings:

Computer Informatics jobs near you
Infographic showing various Computer Informatics job openings in California as of August 2026, with employment types broken down into 87% Full Time, and 13% Part Time. Highlights an 100% In-person job distribution, with an average salary of $84,488 per year, or $40.6 per hour.

Director, Research Informatics

Denali Therapeutics

South San Francisco, CA

$204K - $265K/yr

Full-time

Medical, Retirement

Posted 5 days ago

Job description

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

Research Informatics is responsible for the scientific data platforms and internal software that underpin the full research and development pipeline at Denali Therapeutics. This function owns the strategy, implementation, and ongoing support of the digital tools that enable scientists to register molecular entities and to track, analyze, and document associated experimental data across the full lifecycle, from early discovery through translational and development handoffs. These tools include Denali's Electronic Laboratory Notebook (ELN), the internal experiment data management platforms that underpin our scientific documentation, and the AI capabilities that unlock the full value of our data.
The Director of Research Informatics will lead this function, serving as the strategic and operational owner of our scientific data platforms, including Benchling, Dotmatics, and our internal software and AI tool integration. This individual will define the informatics roadmap, drive stakeholder alignment behind it, and build a high-caliber engineering team, while serving as a trusted technical partner to Discovery, enterprise IT, and other operational leadership. This is a hands-on leadership role: the Director will set technical direction and make software architecture and design-space decisions, not simply manage from a distance.

Key Accountabilities / Core Job Responsibilities

  • Owns the strategy, roadmap, and operational delivery of Research Informatics, including Benchling, Dotmatics, internal software systems, and AI integration.

  • Leads and grows a team responsible for platform support, configuration, validation, and continuous improvement across Discovery, Development, and Technical Operations.

  • Partners with scientists and lab operations leads to translate business and scientific requirements into scalable, well-engineered platform solutions.

  • Serves as subject matter expert on ELN capabilities and experiment data workflows, advising on platform selection and integration strategy.

  • Communicates platform strategy, status, and risk clearly to senior stakeholders, from group leaders to senior management.

  • Engages hands-on in configuration and platform build work, alongside strategic oversight.

  • Drives vendor relationships and manages platform migrations, escalations, and contract performance.

  • Explores and integrates next-generation, AI-driven experiment capture concepts, including passive documentation architectures that reduce manual interface dependency while preserving compliant, attributable records.

  • Owns roadmap prioritization and backlog decisions, balancing input from scientific, engineering, and IT stakeholders.

  • Leads direct report(s) through annual goal setting, growth planning, adherence to company policies, maintains training compliance, and provides ongoing feedback on growth, development, and areas of improvement.

Qualifications/Skills

  • Typically requires a Bachelor's degree in a technical field (computer science, data science, engineering, or related); advanced degree preferred.

  • Typically requires 10+ years building and delivering software solutions, including 7+ years in pharma, biotech, or life sciences supporting laboratory informatics or scientific platforms.

  • Typically requires 8+ years of people management experience, including building and growing engineering teams.

  • Hands-on expertise with scientific data platforms (e.g., Benchling, Dotmatics) and experience leading ELN/registry migrations preferred.

  • Experience partnering with enterprise IT on security, licensing, and infrastructure, and familiarity applying AI/ML workflows to biological or chemical data, preferred.

Salary Range: $204,000.00 to $265,000.00 .Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers

This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

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