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Clinical Research Associate 1099 Jobs (NOW HIRING)

ICON

Senior Clinical Research Associate

Blue Bell, PA · On-site

ICON plc is seeking an experienced Senior Clinical Research Associate (Senior CRA) or Clinical Research Associate (CRA) to join our dynamic, collaborative team. In this role, you will be a key ...

Icon plc

Senior Clinical Research Associate

Houston, TX · Hybrid

Contract Senior Clinical Research Associate - Home-Based (US) ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to ...

ICON

Senior Clinical Research Associate

Blue Bell, PA · On-site

As a Clinical Research Associate at ICON , you will play a pivotal role in designing and analyzing clinical trials, interpreting complex medical data, and contributing to the advancement of ...

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Clinical Research Associate 1099 information

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$36K

$94.3K

$143.5K

How much do clinical research associate 1099 jobs pay per year?

As of Jul 16, 2026, the average yearly pay for clinical research associate 1099 in the United States is $94,314.00, according to ZipRecruiter salary data. Most workers in this role earn between $62,500.00 and $128,000.00 per year, depending on experience, location, and employer.

What is a Clinical Research Associate 1099?

A Clinical Research Associate (CRA) 1099 is an independent contractor who oversees clinical trials for pharmaceutical, biotechnology, or medical device companies. Unlike traditional W-2 employees, CRAs working under a 1099 agreement operate as self-employed professionals, managing their own taxes and benefits. Their responsibilities include monitoring study sites, ensuring compliance with protocols, and safeguarding patient safety and data integrity. This role offers more flexibility but also requires handling administrative tasks that would typically be managed by an employer.

What are some common challenges independent (1099) Clinical Research Associates face, and how can they be managed?

Independent Clinical Research Associates (CRAs) often face challenges such as managing multiple sponsor expectations, maintaining consistent study documentation, and navigating variable workloads. As a 1099 contractor, you are responsible for your own scheduling, invoicing, and tax obligations, which requires strong organizational skills. Building clear communication channels with sponsor teams and staying updated on regulatory requirements can help ensure study quality and compliance. Networking with other independent CRAs and utilizing professional resources can also provide support and guidance.

What are the key skills and qualifications needed to thrive as a Clinical Research Associate 1099, and why are they important?

To thrive as a Clinical Research Associate 1099, you need a solid understanding of clinical trial protocols, GCP (Good Clinical Practice) guidelines, and typically a bachelor’s degree in life sciences or a related field. Familiarity with electronic data capture (EDC) systems, regulatory documentation, and often certifications like ACRP or SOCRA are important. Strong organizational skills, attention to detail, and effective communication enable you to manage multiple studies and collaborate with diverse teams. These skills ensure compliance, data integrity, and the successful execution of clinical research projects.

What is the difference between Clinical Research Associate 1099 vs Clinical Research Associate W-2?

AspectClinical Research Associate 1099Clinical Research Associate W-2
Employment StatusIndependent contractorEmployee
TaxationResponsible for own taxes, self-employedTaxes withheld by employer
Work EnvironmentTypically contract-based, flexible locationsUsually full-time, in-house or site-based
CredentialsOften similar certifications, e.g., CCR, but no employer-mandated benefitsSame certifications, with benefits provided by employer

The main difference between a Clinical Research Associate 1099 and a W-2 is employment status. The 1099 role is an independent contractor, offering flexibility but requiring self-management of taxes and benefits. The W-2 role is a traditional employee position with taxes and benefits handled by the employer. Both roles often require similar credentials and work in comparable environments, but their employment structure impacts taxes, benefits, and work arrangements.

More about Clinical Research Associate 1099 jobs
What cities are hiring for Clinical Research Associate 1099 jobs? Cities with the most Clinical Research Associate 1099 job openings:
What states have the most Clinical Research Associate 1099 jobs? States with the most job openings for Clinical Research Associate 1099 jobs include:
What job categories do people searching Clinical Research Associate 1099 jobs look for? The top searched job categories for Clinical Research Associate 1099 jobs are:
Clinical Research Associate 1099 jobs near you
Infographic showing various Clinical Research Associate 1099 job openings in the United States as of July 2026, with employment types broken down into 83% Full Time, and 17% Part Time. Highlights an 75% In-person, and 25% Remote job distribution, with an average salary of $94,314 per year, or $45.3 per hour.
Senior Clinical Research Associate

Senior Clinical Research Associate

Cognitive Research Corporation

Remote

Full-time

Posted 8 days ago

Job description

The Senior Clinical Research Associate is responsible for overseeing the execution of clinical trials at Investigative Sites. The Clinical Research Associate acts as a liaison between the study Sponsor, CRC and Investigative Sites. They will proactively identify and resolve clinical project issues and participate in process improvement initiatives as applicable. The CRA facilitates successful execution of studies by Investigative Sites and helps to ensure the rights, safety and welfare of human research participants as well as data integrity in clinical trials.
Essential Duties & Responsibilities
  • Initiates, monitors, and closes-out investigative sites in accordance with FDA/ICH regulations.
  • Tracks and maintains study specific non-Case Report Form database
  • Administers Clinical research projects; collects investigator documentation, site management, clinical contact, and prepare reports as required
  • Ensures appropriate source document review and source document verification as required
  • Reviews Case Report Forms to identify erroneous, missing, or incomplete data
  • Generates queries to resolve problematic data to appropriate personnel, and review responses to assure the database is updated accordingly
  • Verifies study drug accountability; generates and tracks drug shipments and storage
  • Travels as necessary, based on project needs and according to Clinical Monitoring Plan requirements
  • Performs data collection, retrieval, entry and clean up as necessary
  • Develops and maintains strong relationships with Investigator(s) and site staff
  • Independently manages sites resulting in acceptable Quality Assurance reports.
  • Escalates study/site issues/deviations appropriately
  • Serves as lead monitor for a protocol or project by creating study files, arranges monitoring schedules, leads the project team, organize and run meetings and performs other project management duties as assigned by management
  • Writes Clinical Trial Reports, analyzing and presenting trial results in a clear and accurate format
  • Reports, writes narratives, and follows-up on reported serious adverse events
  • Interacts and attends client meetings, as appropriate
  • Mentors junior staff/CRAs
  • Quality oversight checks of monitoring
  • Performs other duties as assigned

Qualifications
  • Bachelor's degree, or RN, in a related field or equivalent combination of education, training and experience
  • Minimum 5 years' experience as a CRA; experience overseeing clinical trials in the pharmaceutical, hospital or CRO industry
  • Ability to work and travel independently with minimal supervision
  • Experience with numerous EDC systems.
  • Advanced knowledge of GCPs, ICH guidelines, FDA and other applicable regulations
  • Specialized knowledge of CNS therapeutic areas
  • Proficiency in Microsoft Office, Zoom and Adobe
  • Excellent writing and verbal skills, English language proficiency
  • Meticulous attention to detail
  • Time management and ability to prioritize tasks
  • Ability to travel up to 70%

Department Clinical Operations Role Senior Clinical Research Associate Locations Remote, US Remote status Fully Remote Employment type Full-time

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