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Biotherapeutics Jobs (NOW HIRING)

Manifold Bio

Senior Director, Biotherapeutics

Boston, MA · On-site

$240K - $340K/yr

Manifold Bio is seeking an exceptional Senior Director of Biotherapeutics to help guide and mature our discovery, characterization, and production of shuttled therapeutics. This role spans discovery ...

Vrtx

Executive Director, Biotherapeutics DMPK

Boston, MA · On-site

$268K - $402K/yr

We are seeking an accomplished and strategic leader to serve as Executive Director, Biotherapeutics DMPK-Bioanalysis (DMPK-BA), to guide the DMPK-BA strategy for our rapidly growing Biotherapeutics ...

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$128.4K

$156.5K

How much do biotherapeutics jobs pay per year?

As of Aug 16, 2026, the average yearly pay for biotherapeutics in the United States is $128,353.00, according to ZipRecruiter salary data. Most workers in this role earn between $114,500.00 and $150,000.00 per year, depending on experience, location, and employer.

What types of teams or departments do biotherapeutics professionals typically collaborate with?

Biotherapeutics professionals regularly work alongside multidisciplinary teams, including research scientists, quality assurance, regulatory affairs, clinical development, and manufacturing units. Collaboration is crucial for progressing biotherapeutic candidates from research and development through to clinical trials and commercial production. Open communication with these teams enables smooth coordination, helps maintain compliance, and accelerates problem-solving. By working cross-functionally, Biotherapeutics professionals contribute to the overall success of new therapies reaching the market safely and efficiently.

What is a biotherapeutics?

A Biotherapeutics job involves researching, developing, and producing biological therapies derived from living organisms to treat diseases. Professionals in this field work in biotechnology or pharmaceutical companies, focusing on areas like monoclonal antibodies, cell and gene therapy, and protein therapeutics. Responsibilities may include drug discovery, process development, clinical testing, and regulatory compliance. These roles require expertise in biology, biomedical engineering, or related fields.

What are the key skills and qualifications needed to thrive in the biotherapeutics position, and why are they important?

To excel in a Biotherapeutics role, you typically need an advanced degree in life sciences such as biology, biochemistry, or related fields, along with experience in drug development or biotechnology. Familiarity with laboratory information management systems (LIMS), bioanalytical techniques, regulatory guidelines (such as GLP/GMP), and specialized equipment is essential. Strong problem-solving skills, attention to detail, and effective collaboration are important soft skills. Mastery of these abilities ensures the development of safe and effective biotherapeutic products while meeting strict regulatory and scientific standards.

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Biotherapeutics jobs near you
Infographic showing various Biotherapeutics job openings in the United States as of August 2026, with employment types broken down into 92% Full Time, 1% Part Time, 6% Contract, and 1% Nights. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $128,353 per year, or $61.7 per hour.

Senior Director, Biotherapeutics

Manifold Bio

Boston, MA • On-site

$240K - $340K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 4 days ago

Job description

Manifold Bio is a platform biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo screening to unlock tissue-targeted medicines and organism-scale models of living systems. Using proprietary molecular barcoding technology, we screen hundreds of thousands of protein designs simultaneously in living systems, producing in vivo-validated datasets at a scale no one else can match. The datasets power our computational models, which leads to better drug designs, creating a flywheel that gets stronger with every campaign. Our team of protein engineers, biologists, and computational scientists works across this full stack to pursue programs both internally and with leading pharma companies.
Position:

Manifold Bio is seeking an exceptional Senior Director of Biotherapeutics to help guide and mature our discovery, characterization, and production of shuttled therapeutics. This role spans discovery and nonclinical development, including bioengineering strategies to generate best-in-class molecules and oversight of external contract manufacturing organizations (CDMOs) to develop processes and manufacture drug product for clinical trials.

As a member of our leadership team, you will contribute to high-level strategy and help build internal resources to support our ambitious growth plans. This is a unique opportunity to shape the future of a cutting-edge biotechnology company while working with a collaborative, innovative team.

Key Responsibilities:

Team Management & Development

  • Manage and mentor internal protein scientists and protein engineers
  • Build and focus teams in a capital-efficient manner to support current and future pipeline needs
  • Foster strong collaborative interactions between biotherapeutics teams and teams supporting AI/ML protein design and screening, oligonucleotide therapeutic discovery, and pharmacology

Program Execution

  • Support the discovery and characterization of shuttled therapeutics via 1-2 matrix project teams, serving as biotherapeutics lead or project lead
  • Map out critical path activities through IND-enabling studies and ensure key activities are resourced and executed efficiently
  • Engage with consultants, contractors and  CROs/CDMOs to efficiently build expertise and capabilities that accelerate program progression
  • Set and implement strategy for developability assessment and early-stage de-risking
  • Prepare and present data packages for partnering discussions and investor presentations

Strategic Leadership

  • Contribute to high-level strategy and key objectives for discovery and development of shuttled therapeutics
  • Establish development candidate nomination criteria for novel biotherapeutics with particular focus on developability metrics 
  • Identify and outline opportunities for backup molecule discovery and selection
Qualifications:

Required Experience & Skills

  • Extensive experience in biotherapeutics across a range of protein modalities
  • Proven track record engineering antibodies for clinical development
  • Deep knowledge of state-of-the-art protein engineering approaches
  • Experience with protein expression systems, purification methods, and characterization including developability assays
  • Prior experience liaising with CDMOs

Preferred Qualifications

  • Expertise with novel modalities and complex formats, including ADCs, tissue-targeted therapeutics, and bispecific antibodies
  • Understanding of high-throughput screening and bioanalytical technologies
  • Experience with generative AI models for protein and/or oligonucleotide design

Base Salary Range: $240,000-340,000

This reflects the typical offer range for this role, based on experience, role scope, and internal equity. Final compensation decisions are made using a consistent leveling framework and consider the candidate's experience, interview performance, and expected impact.

This role is eligible for:

  • Annual performance-based target bonus
  • Stock options
  • Comprehensive medical, dental, and vision coverage
  • 401(k) plan
  • Flexible paid time off and holidays
  • Perks including on-site gym, onsite lunch, and commuter support

Our compensation ranges are reviewed annually to ensure alignment with market trends and internal equity.

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