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Biotech Startup Director Clinical Operations information

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$146K

$282.5K

How much do biotech startup director clinical operations jobs pay per year?

As of Aug 15, 2026, the average yearly pay for biotech startup director clinical operations in the United States is $145,969.00, according to ZipRecruiter salary data. Most workers in this role earn between $102,000.00 and $173,500.00 per year, depending on experience, location, and employer.

What does a biotech startup director clinical operations do?

A Biotech Startup Director of Clinical Operations oversees the planning, execution, and management of clinical trials at an emerging biotechnology company. Their responsibilities include building and leading the clinical operations team, ensuring regulatory compliance, developing trial protocols, managing budgets and timelines, and collaborating with cross-functional departments like regulatory affairs, medical affairs, and R&D. They play a critical role in advancing new therapies from early-stage trials through to later phases, often in a fast-paced and resource-limited startup environment.

What are some common challenges faced by a biotech startup director clinical operations, and how can they be addressed?

A Biotech Startup Director of Clinical Operations often faces challenges such as limited resources, rapidly shifting priorities, and the need to establish efficient processes from the ground up. Balancing the demands of regulatory compliance with the agility required in a startup environment can be particularly complex. Success often depends on building a strong, cross-functional team, leveraging external partnerships, and proactively communicating with stakeholders to ensure alignment and timely decision-making. Adapting quickly and fostering a culture of collaboration are essential to overcoming these hurdles.

What are the key skills and qualifications needed to thrive as a biotech startup director clinical operations?

To excel as a Biotech Startup Director of Clinical Operations, you need a deep understanding of clinical trial management, regulatory compliance, and drug development, typically supported by an advanced degree in life sciences and significant industry experience. Familiarity with clinical trial management systems (CTMS), electronic data capture (EDC) platforms, and GCP certification is commonly required. Strong leadership, strategic thinking, and effective communication are essential soft skills for leading teams and collaborating with stakeholders. These competencies ensure that clinical trials are executed efficiently, safely, and in compliance with regulatory standards, which is crucial for the success and growth of a biotech startup.

What is the difference between Biotech Startup Director Clinical Operations vs Clinical Project Manager?

AspectBiotech Startup Director Clinical OperationsClinical Project Manager
ResponsibilitiesOversees all clinical operations, strategic planning, team leadership, and regulatory compliance in a biotech startup setting.Manages individual clinical trials, coordinates project activities, timelines, and budgets under supervision.
Required CredentialsTypically requires advanced degrees (e.g., MS, PhD), clinical research experience, and leadership skills.Requires a bachelor's or master's degree in life sciences or related field, with experience in clinical trial management.
Work EnvironmentFast-paced startup environment with cross-functional teams, high responsibility, and strategic focus.Structured environment within pharmaceutical or biotech companies, focusing on specific trial execution.

The Biotech Startup Director Clinical Operations holds a broader leadership role, overseeing multiple trials and strategic initiatives, while the Clinical Project Manager focuses on managing individual clinical studies. Both roles require clinical research experience, but the director position demands more leadership and strategic planning skills.

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Biotech Startup Director Clinical Operations jobs near you
Infographic showing various Biotech Startup Director Clinical Operations job openings in the United States as of August 2026, with employment types broken down into 86% Full Time, 11% Part Time, 1% Temporary, and 2% Contract. Highlights an 94% Physical, 2% Hybrid, and 4% Remote job distribution, with an average salary of $145,969 per year, or $70.2 per hour.

Senior Manager/Director Clinical Operations

Lycia Therapeutics

South San Francisco, CA • On-site, Remote

$250K/yr

Full-time

This job post has expired 1 day ago. Applications are no longer accepted.

Job description

Lycia Therapeutics is a biotechnology company using its proprietary lysosomal targeting chimera (LYTAC) platform to discover and develop best-in-class therapeutics that degrade extracellular and membrane-bound proteins. These proteins drive a wide range of difficult-to-treat diseases, including autoimmune and inflammatory conditions. Lycia was established in 2019 in collaboration with academic founder and Nobel Laureate Carolyn Bertozzi, Ph.D., professor of chemistry and HHMI investigator at Stanford University. In June, 2026, Lycia Therapeutics completed a $75 million Series D financing to advance its pipeline of LYTAC extracellular protein degraders into the clinic. Lycia is headquartered in South San Francisco. 

Visit https://lyciatx.com/ for more information.


Position Summary

The Senior Manager/Director Clinical Operations will be responsible for oversight and management of up to 2 early phase clinical programs in collaboration with the selected Clinical Research Organization (CRO).   

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Primary Responsibilities:
  • Create and execute clinical operational strategic plans in line with product strategy and resource allocation.
  • Develop study feasibility, cost estimates, input into contracts, work/change orders and analyze tools and processes to support outsourcing efforts.
  • Track clinical program study finances and monthly accruals and review/approve associated clinical site and vendor invoices.
  • Build, develop and train internal staff and external vendors, structure department for enhancing efficiency, and create a highly engaged work environment for attracting and retaining highly qualified clinical operations professionals.
  • Develop and ensure compliance with SOPs and guidelines, FDA regulations and current ICH GCP guidelines.
  • Oversee and maintain the relationships with Contract Research Organizations, vendors,  and  investigative sites.
  • Participate on clinical operations and study team meetings.
  • Maintain a high level of professional expertise through familiarity of clinical literature, knowledge of therapeutic area, current medical practice and pharmaceutical regulations.

Additional Expectations

  • Although a remote position, it may be necessary to travel to corporate headquarters up to 2 times per year.
  • Ability to travel to clinical sites or to the CRO, as necessary to support trial management.


Qualifications:
  • B.A/B.S required; M.S., PhD, PharmD, MD or other related advanced scientific degree strongly preferred.
  • Minimum of 7 years for manager and 12 years for director level with progressive advancement within clinical operations in the pharmaceutical/biotech industry.
  • Flexible and dynamic interpersonal approach, entrepreneurial by nature, a collaborative team player who works well with physicians, scientists, managers, peers, and staff.
  • Ability to manage in a consensus environment through teamwork, trust and shared expectations, influencing strategic direction of complex global clinical operations issues, solicit information, listen well, persuade others, make important decisions and shape outcomes.


\\n$169,000 - $250,000 a yearThe salary range for this position are $169,000-198,000 for Sr. Manager and $206,000-250,000 for Director, which reflects the range across all US locations for which we are hiring. Actual salary will depend on the candidate\'s geographic location, along with experience, skills, and qualifications.\\n

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Lycia and other biotech companies have recently noticed an increase in email and social media scams targeting job candidates in our industry. Please note Lycia will post any legitimate job openings directly on our website or through our recruitment partner, Lever. If you wish to verify the legitimacy of a job opening, you may contact us.

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