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The Mayo Clinic RNA Discovery and Therapeutics Program is recruiting for an outstanding mid- career scientist or clinician investigator (PhD, MD, PhD, MD or equivalent) with strong training, expertise, experience, and impactful work in RNA biology with translation into RNA therapeutics including but not limited to ASO, siRNA, aptamers, mRNA therapeutics. The candidate is expected to have a strong track record of extramural funding, high impact publications, as well as a proven record of collaborative team science endeavors as exemplified by leading multi-institutional grants and/or inter-disciplinary programs in the area of RNA biology, therapeutics and applications. The ideal candidate will have national/international recognition in one or more of these areas, with 10+ years of experience and expertise. The candidate is expected to continue both their extramurally funded program, as well as bring unique and new techniques in the RNA therapeutics field such as novel therapeutic development, synthetic RNA therapeutics, and RNA treatment deliveries to name a few examples. The candidate will be an investigator in one or more of the disease areas that are high priority under the Enterprise Research initiatives, namely cancer, complex neurological diseases, and disciplines that cater to preventing end-organ failure in heart, lung, liver, kidney or brain.
This position will be located at Mayo Clinic Florida with significant enterprise engagement.
The investigator will be expected to develop and apply their research expertise and tools for generating RNA therapeutic applications in collaboration with other investigators and taking advantage of the innovative, translational environment at Mayo Clinic.
There will be a strong emphasis on application of knowledge and platforms from this program to the broader Mayo Clinic Research Initiatives and the RNA Accelerator Platform with a goal to impact patient care. Candidate's ability to engage with basic and translational scientists, clinical trialists and leverage the extensive clinical trial platforms at Mayo Clinic to bring RNA discoveries to patients is considered a major strength. This collaborative framework will encompass basic science and clinical departments, Center for Regenerative Biotherapeutics, and Business Development. The ideal candidate will be poised to take advantage of large-scale, multi-PI RFAs from the NIH, DARPA and other agencies.
The candidate will be eligible for Full Faculty privileges and also be involved in the education of trainees.
Highlights of Mayo Clinic Research Enterprise:

• Over 5,200 research personnel, including 321 faculty level research investigators and 948 physicians who are actively involved in research.
• 11,220 peer-reviewed papers were published in 2023.
• Investments in research each year, resulting in hundreds of new clinical trials. In 2024, the institution received over $753 million in extramural research awards supplemented with over $517 million of institutional support.
• Nearly 10,000 active studies involving human participants in progress. More than 5,900 research grants and contracts.
• State-of-the art laboratories and shared resource facilities, including those for microscopy and imaging, cell and molecular biology, animal models, production of iPS cells and clinical grade MSCs, biomedical engineering and mathematics, materials testing, a Medical Genomics Facility, a Mouse Modeling Facility, Molecular and Microscopic Core Facilities, and unique Human Disease Tissue Banks.
• Over 420,000 square feet of research laboratory space includes several robotic freezers capable of storing 3.5 million DNA samples.
• Mayo Clinic supports innovation and has a wealth of resources available - including an integrated health record and collaboration with top specialists.
• Mayo Clinic Brain Bank housed within the Department of Neuroscience and including 11,000 unique brains with neuropathologic characterizations from donors with neurodegenerative diseases and other conditions.
• Mayo Clinic has a dedicated RNA Facility which is equipped with current high-end technology and dry laboratory infrastructure and resources to design, manufacture and package RNA products for research applications.
• Mayo Clinic has a dedicated RNA Facility which is equipped with current high end technology and dry laboratory infrastructure and resources to design, manufacture and package RNA products for research applications.
• The Center for Regenerative Biotherapeutics with 40 manufacturing engineers across the Mayo Clinic sites with the ability to biomanufacturer clinical-grade products in clean room (cGMP regulated) laboratory.

About Mayo Clinic
Mayo Clinic is top ranked in more specialties than any other care provider according to U.S. News & World Report. With a 73,000-person workforce, Mayo Clinic cares for more than 1.3 million people each year with serious or complex illnesses from all 50 U.S. states and 130 countries. Mayo Clinic is the largest not-for-profit, multidisciplinary academic medical center in the world with over 4,000 physicians and scientists in an integrated multi-campus system spanning the globe.
The unified mission at Mayo Clinic is to provide the best patient care, backed by our expertise and supported by innovation in education, research and practice, to bring hope and healing in times of need. We embrace collegial relationships among campuses (Arizona, Florida and Minnesota) allowing for best practices and innovation to help solve the most serious complex medical challenges-one patient at a time.
As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in a highly competitive compensation package with substantial long-term institutional and departmental support for salary, personnel, equipment, and travel as well as a competitive startup package all designed to ensure immediate and continued success. Additional benefits for faculty at Mayo Clinic include intramural funding opportunities for research and innovation. We provide an outstanding, comprehensive benefits package that includes plenty of options for medical, dental and vision care; flexible spending accounts; life insurance; short- and long-term disability coverage; travel allowance; generous time away; and more! We are proud to be among the few U.S. companies to provide a pension benefit at no cost to employees plus you can add the Mayo 403(b) plan which features an employer match.
Qualifications
The successful candidate will have a PhD, MD/PhD, MD (or equivalent degree) with a sustained track record of success in extramural funding (current R01 or R01-equivalent funding as PI), publications, and collaborations with scientists and physicians. Appointment and academic rank will be determined based on the candidate's qualifications. Successful candidates will be at the level of Associate or full tenured Professor.
Applications should include a full CV/Bibliography, statement of research interests, and list of references.