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X Ray Crystallography Jobs (NOW HIRING)

Novartis

Principal Scientist, Structural Biologics

San Diego, CA · On-site

$108K - $201K/yr

  • Medical

  • Life

  • Retirement

  • PTO

The ideal candidate will have hands-on experience in all aspects of the gene to structure pipeline including the acquisition and interpretation of structural biology data from X-ray crystallography ...

Guidehouse

Biologist

Bethesda, MD · On-site

$85K - $141K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

Process and analyze structural datasets, including but not limited to cryo-electron microscopy (cryo-EM) and X-ray crystallography data. * Refine structural models and interpret structural findings.

Guidehouse

Biologist

Bethesda, MD

$85K - $141K/yr

  • Medical

  • Dental

  • Vision

  • Life

  • Retirement

Process and analyze structural datasets, including but not limited to cryo-electron microscopy (cryo-EM) and X-ray crystallography data. * Refine structural models and interpret structural findings.

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X Ray Crystallography information

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How much do x ray crystallography jobs pay per week?

As of Aug 15, 2026, the average weekly pay for x ray crystallography in the United States is $2,094.00, according to ZipRecruiter salary data. Most workers in this role earn between $1,740.38 and $2,500.00 per week, depending on experience, location, and employer.

What is x ray crystallography?

An X-ray Crystallography job involves analyzing the atomic and molecular structure of crystals using X-ray diffraction techniques. Professionals in this field prepare crystal samples, operate X-ray diffraction equipment, and interpret diffraction patterns to determine the arrangement of atoms in a material. These roles are common in research institutions, pharmaceutical companies, and material science industries, contributing to drug development, structural biology, and material characterization.

What are the key skills and qualifications needed to thrive in x ray crystallography?

To thrive in X-ray Crystallography, you need a strong background in structural biology, chemistry, or physics, with experience in crystallization techniques and data analysis. Familiarity with X-ray diffraction instruments, crystallography software such as CCP4 or Phenix, and potentially a relevant certification or advanced degree is important. Attention to detail, problem-solving ability, and effective communication are valuable soft skills for collaborating with research teams. These qualities ensure accurate experimental results, successful structure determination, and the ability to work efficiently in multidisciplinary scientific environments.

What are some typical challenges faced in x ray crystallography roles?

In X-ray Crystallography roles, one common challenge is successfully growing high-quality crystals suitable for diffraction, which can require persistence and creative problem-solving. Interpreting complex data and troubleshooting issues with instrumentation or software are also frequent aspects of the work. Collaboration with chemists, biologists, and computational scientists is often necessary to optimize experiments and analyze results. This dynamic environment helps build versatile skills but also requires adaptability and strong teamwork for effective progress.

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X Ray Crystallography jobs near you
Infographic showing various X Ray Crystallography job openings in the United States as of August 2026, with employment types broken down into 4% As Needed, 70% Full Time, 17% Part Time, and 9% Contract. Highlights an 98% Physical, and 2% Remote job distribution, with an average salary of $108,888 per year, or $52.4 per hour.

Radial Postdoctoral Fellow - Dynamic Structural Biology (diffUSE Project)

Astera Institute

Ithaca, NY • On-site

$70K/yr

Contractor

Re-posted 10 days ago

Job description

Position Summary

The diffUSE Project is seeking a highly motivated structural biologist to push the boundaries of X-ray crystallography for studying protein dynamics. Work will be done within the Ando lab. The Ando lab is known for developing and integrating advanced structural techniques (crystallography, SAXS, and cryo-EM) and bioinformatics to visualize protein motions underlying enzyme catalysis and allostery. The postdoctoral fellow would contribute to the Diffuse Project, a multi-institution initiative around mainstreaming diffuse scattering techniques, which use the hidden data from X-ray crystallography experiments to extract information on protein motion. The project is an open-science collaboration that brings together expertise across disciplines in
a goal-driven, team-oriented environment. The successful candidate will drive the application of diffuse scattering to biological questions by growing protein crystals, collecting synchrotron data, and applying computational tools developed within the collaboration.


Applicants should hold a PhD in structural biology or a related field and have experience with X-ray crystallography. Strong experimental skills, quantitative thinking, and a rigorous approach to problem-solving are essential. The successful candidate will be embedded within one or more diffUSE Project teams, depending on their interests and expertise. Current areas of opportunity include protein expression and purification, software development for data processing and analysis, molecular dynamics simulations, and theoretical approaches such as model refinement and phase retrieval. In addition to contributing to the broader collaboration, the candidate will participate fully in Ando Lab activities and demonstrate leadership through mentoring and fostering a positive, collaborative, and productive research environment. Strong written and oral communication skills are required, as the position involves contributing to ongoing dissemination of results through publications as well as open-science formats such as
online notebooks and blog posts.


Responsibilities

  • Design and execute experiments to probe protein dynamics using X-ray crystallography, including crystal growth, optimization, and data collection

  • Collect and analyze diffraction data (including diffuse scattering) at synchrotron facilities

  • Apply and/or develop computational tools for modeling conformational ensembles from experimental data

  • Collaborate with interdisciplinary teams across the diffUSE Project (experimental, computational, and theoretical groups)

  • Contribute to method development and benchmarking for dynamic structural biology

  • Mentor graduate and undergraduate students in the team

  • Communicate results through open-science platforms


Required Qualifications

  • PhD in Structural Biology, Biophysics, Biochemistry, Chemistry, or a related field

  • Demonstrated experience with X-ray crystallography (data collection, processing, refinement)

  • Strong experimental skills in protein expression, purification, and/or crystallization

  • Ability to think rigorously about physical models and experimental data

  • Strong written and verbal communication skills

  • Ability to work effectively in a collaborative, interdisciplinary environment


Preferred Qualifications

  • Experience with advanced X-ray instrumentation

  • Experience developing experimental or theoretical approaches for dynamic structural biology (such as time-resolved X-FEL, energy landscapes by cryo-EM)

  • Experience with scientific programming (Python, MATLAB, etc.)

  • Engagement in open-science practices

Compensation

Commensurate with experience.

  • Benefits summary

Application Instructions

Please submit:

  • CV

  • Cover letter

  • Contact information for 3 references


Applications will be reviewed on a rolling basis until the position is filled.

Compensation Range: $70K