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Upstream Jobs in Raleigh, NC (NOW HIRING)

Upstream Rehabilitation

Physical Therapist

Cary, NC · On-site

$1.5K - $1.9K/wk

At Results Physiotherapy, part of the Upstream Rehabilitation network, you can focus on patient care while advancing your career in outpatient orthopedic physical therapy. We're hiring full-time, ...

Upstream Rehabilitation , Inc.

Physical Therapist

Garner, NC · On-site

$1.4K - $1.9K/wk

At Results Physiotherapy, part of the Upstream Rehabilitation network, you can focus on patient care while advancing your career in outpatient orthopedic physical therapy. We're hiring full-time, ...

Upstream Rehabilitation , Inc.

Physical Therapist

Cary, NC · On-site

$1.6K - $2.1K/wk

At Results Physiotherapy, part of the Upstream Rehabilitation network, you can focus on patient care while advancing your career in outpatient orthopedic physical therapy. We're hiring full-time, ...

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All JobsUpstream JobsUpstream Jobs in Raleigh, NC

Upstream information

See Raleigh, NC salary details

$57.4K

$88.2K

$151.2K

How much do upstream jobs pay per year?

As of Aug 12, 2026, the average yearly pay for upstream in Raleigh, NC is $88,234.00, according to ZipRecruiter salary data. Most workers in this role earn between $75,300.00 and $87,000.00 per year, depending on experience, location, and employer.

What are some common challenges faced by professionals working in upstream oil and gas operations?

Professionals in upstream oil and gas often contend with challenging field conditions, complex regulatory requirements, and the need to balance operational efficiency with safety and environmental standards. The role frequently involves working in remote locations, collaborating with multidisciplinary teams, and adapting to rapidly changing technologies. Navigating project timelines, resource constraints, and evolving industry regulations can also present significant challenges, but these aspects offer valuable experience and opportunities for skill development and career advancement.

What are upstream jobs in the oil and gas industry?

Upstream jobs in the oil and gas industry refer to positions involved in the exploration and production of oil and natural gas. This includes locating oil and gas fields, drilling wells, and extracting resources from beneath the earth's surface. Common upstream roles include geologists, drilling engineers, and production operators. These jobs are crucial in the early stages of the energy supply chain and often involve working in the field or on offshore rigs.

What is the difference between Upstream vs Downstream?

AspectUpstreamDownstream
Primary FocusExploration, drilling, and production of oil and gasRefining, distribution, and marketing of oil and gas products
Work EnvironmentOil fields, drilling sites, exploration areasRefineries, distribution centers, retail outlets
Required CredentialsGeology, petroleum engineering, certifications in drilling and safetyChemical engineering, marketing, logistics certifications
Industry UsageExploration and production companiesRefining companies, oil and gas marketers

Upstream involves the exploration and extraction of oil and gas, focusing on drilling and production. Downstream covers refining, distribution, and selling petroleum products. Both roles are essential in the oil industry but differ in their focus, work environment, and required skills.

What are the key skills and qualifications needed to thrive as an upstream oil and gas engineer, and why are they important?

To thrive as an Upstream Oil & Gas Engineer, you need a solid background in petroleum engineering, geology, or a related field, often supported by a relevant degree. Familiarity with reservoir simulation software, drilling technologies, and industry safety standards is essential. Strong analytical thinking, teamwork, and effective communication distinguish top performers in this role. These skills ensure efficient resource extraction, operational safety, and collaboration in complex exploration and production environments.
What are popular job titles related to Upstream jobs in Raleigh, NC? For Upstream jobs in Raleigh, NC, the most frequently searched job titles are:
What job categories do people searching Upstream jobs in Raleigh, NC look for? The top searched job categories for Upstream jobs in Raleigh, NC are:
What cities near Raleigh, NC are hiring for Upstream jobs? Cities near Raleigh, NC with the most Upstream job openings:
Upstream jobs near you
Infographic showing various Upstream job openings in Raleigh, NC as of August 2026, with employment types broken down into 56% Full Time, and 44% Contract. Highlights an 100% In-person job distribution, with an average salary of $88,234 per year, or $42.4 per hour.

Process Engineer - Solution Prep, Upstream, and Downstream

Amgen, Inc.

Holly Springs, NC • On-site

Full-time

Re-posted 18 days ago

Job description

Career Category
Engineering
Job Description
Join Amgen's Mission of Serving Patients
At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do.
Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Be part of Amgen's newest and most advanced drug substance manufacturing plant. When completed, the Amgen FleX batch facility will combine the latest in disposable technologies with traditional stainless steel equipment to allow for maximum flexibility in operations The FleX Batch facility will not only feature the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it will also integrate sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027.
Process Engineer - Solution Prep, Upstream, and Downstream
What you will do
In this vital role you will be joining the Facilities & Engineering (F&E) group to partner closely with the corporate engineering team to design, build, commission, and qualify new equipment and systems needed for drug substance production as well as developing domain expertise to support operations upon start-up.
Site design, construction, start-up, and operational readiness:
  • Support the commissioning and qualification of manufacturing systems in alignment with GMP requirements and interact with regulatory inspectors.

  • Ensure systems are installed and operate safely and comply with pertinent environmental health/safety practice, rules and regulations.

  • Support commissioning and qualification of systems to ensure their operational capability is aligned with manufacturing requirements and GMP regulations.

  • Interact with regulatory inspectors as a manufacturing systems owner to communicate and demonstrate appropriate regulatory compliance of operating systems.

  • Assist with new product/technology introductions by performing engineering assessments, implementing equipment modifications, and supporting engineering runs.

Site Operations:
  • Provide system support for biopharmaceutical process equipment. Assist in identifying and implementing engineering-based improvements or upgrades to equipment or facility systems.

  • Support the development of business cases for improvements, identification of design requirements, and translation of these requirements into process equipment/system design, specifications, and supporting the construction, startup, and validation of improvements.

  • Develop equipment maintenance programs, ensure the availability of spare parts, and coordinate maintenance activities to ensure systems are in proper working order.

  • Provide system guidance to identify performance risks and implement risk reduction strategies.

  • Provide problem solving support to reduce production downtime. This includes supporting technical root cause analysis and implementation of corrective/preventive action.

  • Provide rotational on-call support and/or shift support based on business needs to ensure 24x7 day-to-day reliability of Solution Prep, Upstream and Downstream systems for plant operations.

  • On-site and up to 10% domestic/international travel.

What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The engineering professional we seek enjoys challenges and is motivated to help serve patients with these qualifications.
Basic Qualifications:
Master's degree
OR
Bachelor's degree and 2 years of Engineering experience
OR
Associate's degree and 6 years of Engineering experience
OR
High school diploma / GED and 8 years of Engineering experience
Preferred Qualifications:
  • Bachelor' s degree in Chemical or Mechanical Engineering or similar engineer discipline.

  • 3+ years' of relevant work experience with 2+ years' experience in Biopharmaceutical operations/manufacturing environment

  • Direct knowledge of design and troubleshooting with GMP Biopharmaceutical Production facility equipment/systems with direct experience with Solution Prep, Upstream, and Downstream purification equipment such as weigh and dispense equipment, solution preparation vessels, cell culture reactors, centrifugation, chromatography, viral filtration skids, and UFDF skids as well as other equipment needed to support these processes such as autoclaves, clean in place (CIP) systems, washers, clean steam, water for injection, etc.

  • Ability to analyze problems, develop and propose engineering solutions in a scientific manner using data-driven techniques and analyses (e.g., Data Analytics, Root Cause Analysis (RCA), Statistical Process Control (SPC), Six Sigma, Predictive Maintenance, etc.)

  • Experience working in a regulated environment (e.g. cGMP, OSHA, EPA, etc.) and familiarity with GMP quality systems/processes such as change control, non-conformances, corrective and preventative actions, and qualifications/validation

  • Experience applying engineering principles to the design and implementation of system modifications, introduction of new processes, and the oversight of capital projects

  • Understanding of capital projects in a GMP Biopharmaceutical Production facility including procurement, construction, startup, and validation

  • Understanding of safety requirements working in a GMP Biopharmaceutical Production facility.

  • Independent, ambitious, organized, able to multi-task in project environments, and skilled in communication, facilitation, and teamwork

  • Collaborative teammate prepared to work in and embrace a team based environment that relies on communication for effective decision-making

  • Strong leadership, technical writing, and communication/presentation skills

  • Work schedule flexibility as required to support 24/7 operations, requiring occasional after hours engineering coverage

  • Ability for domestic/international travel.

What you can expect of us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.
In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.
Apply now and make a lasting impact with the Amgen team!
careers.amgen.com
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Salary Range
88,281.00USD -119,439.00 USD

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