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Upstream Manufacturing Associate Jobs (NOW HIRING)

Forge Biologics

GMP Technician I, Upstream

Columbus, OH · On-site

$18.25 - $24.50/hr

... manufacturing processes. Qualifications: * Associate's or Bachelor's degree in a scientific field ... Upstream bioprocessing or biologics manufacturing experience. * Familiarity with cell culture ...

Forge Biologics

GMP Technician I, Upstream

Columbus, OH

$18.25 - $24.50/hr

... manufacturing processes. Qualifications: * Associate's or Bachelor's degree in a scientific field ... Upstream bioprocessing or biologics manufacturing experience. * Familiarity with cell culture ...

TekWissen LLC

Manufacturing Associate

Logan, UT · On-site

$15 - $18/hr

Manufacturing Associate Location: Logan, UT - 84321 Duration: 12 Months Job Type: Temporary ... Perform mutual inspections with upstream and downstream stations. * Identify, correct, and report ...

Astrix Inc

Packaging Associate - Biopharmaceutical

Chicago, IL · On-site

$15.50 - $19/hr

... upstream manufacturing. This role will be with our client who has a global footprint in both R&D ... Associate's degree or higher in Biology, Chemistry, Biotechnology, Pharmacy, or related field * 6 ...

Astrix Inc

Packaging Associate - Biopharmaceutical

Chicago, IL · On-site

$15.50 - $19/hr

... upstream manufacturing. This role will be with our client who has a global footprint in both R&D ... Associate's degree or higher in Biology, Chemistry, Biotechnology, Pharmacy, or related field * 6 ...

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How much do upstream manufacturing associate jobs pay per hour?

As of May 30, 2026, the average hourly pay for upstream manufacturing associate in the United States is $20.84, according to ZipRecruiter salary data. Most workers in this role earn between $16.35 and $23.32 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as an Upstream Manufacturing Associate, and why are they important?

To thrive as an Upstream Manufacturing Associate, you need a solid background in biology or biochemistry, familiarity with Good Manufacturing Practices (GMP), and typically a bachelor's degree in a scientific field. Experience with bioreactor operation, aseptic techniques, and process control systems such as DeltaV is often required. Strong attention to detail, teamwork, and effective communication are crucial soft skills in this role. These competencies ensure the consistent production of high-quality biological products and compliance with industry regulations in a fast-paced environment.

What are some common challenges faced by Upstream Manufacturing Associates, and how can they be successfully managed?

Upstream Manufacturing Associates often encounter challenges such as maintaining sterility in bioprocessing environments, troubleshooting equipment malfunctions, and adapting to rapidly changing production schedules. Successfully managing these challenges requires strict adherence to standard operating procedures (SOPs), strong attention to detail, and effective communication with cross-functional teams like quality assurance and process engineering. Proactively seeking feedback, participating in ongoing training, and staying organized can help associates stay ahead of potential issues and contribute positively to team goals.

What are Upstream Manufacturing Associates?

Upstream Manufacturing Associates are professionals who work in the early stages of biopharmaceutical production, primarily focusing on cell culture and fermentation processes. They are responsible for preparing and maintaining bioreactors, monitoring cell growth, and ensuring optimal conditions for producing biological products such as proteins or vaccines. Their role is crucial in setting the foundation for downstream purification and final product manufacturing. Upstream Manufacturing Associates often work in cleanroom environments and follow strict safety and quality protocols.

What is the difference between Upstream Manufacturing Associate vs Downstream Manufacturing Associate?

AspectUpstream Manufacturing AssociateDownstream Manufacturing Associate
Primary ResponsibilitiesBioreactor operation, cell culture, media preparationPurification, filtration, packaging of products
Work EnvironmentCleanroom, laboratory, manufacturing floorCleanroom, laboratory, manufacturing floor
Required SkillsBioprocessing, sterile techniques, equipment handlingFiltration, chromatography, aseptic processing
CertificationsGMP training, sterile technique certificationGMP training, sterile technique certification

Both roles are essential in biopharmaceutical manufacturing, with upstream associates focusing on the early stages of production like cell culture, and downstream associates handling product purification and finishing. They often work in similar environments and require comparable certifications, but their specific tasks differ within the manufacturing process.

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Upstream Manufacturing Associate jobs near you
Infographic showing various Upstream Manufacturing Associate job openings in the United States as of May 2026, with employment types broken down into 84% Full Time, 8% Temporary, and 8% Contract. Highlights an 100% In-person job distribution, with an average salary of $43,341 per year, or $20.8 per hour.
GMP Technician I, Upstream

GMP Technician I, Upstream

Forge Biologics

Columbus, OH • On-site

$18.25 - $24.50/hr

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 26 days ago

Job description

Forge Your Future with Us:
At Forge Biologics, we believe in turning bold ideas into life-changing realities. Our mission is simple yet powerful: to enable access to life-changing gene therapies and help bring them from ideas into reality. We partner with scientists, physicians, biotech and pharma innovators, and patient communities - all united by one goal: improving lives. If you're driven by purpose and excited to make a tangible impact, this is where your journey begins.
Our team works out of The Hearth, a state-of-the-art, 200,000-square-foot cGMP facility in Columbus, Ohio. Here, you won't just watch innovation happen - you'll be part of it. Whether you're scaling AAV manufacturing, collaborating on cutting-edge therapies, or supporting complex technical projects, you'll play a key role in bringing hope to patients with genetic diseases.
What sets Forge apart is our culture of H.O.P.E. We are hardworking, showing up each day with determination and grit. We are open, creating a space where ideas flow freely, and every voice is valued. We are purpose-driven, with every task directly tied to changing lives. And we are engaged, energized by the challenges we face and the milestones we achieve together.
At Forge, your growth matters. We're committed to helping you expand your skills, take on new challenges, and develop your career through mentorship, hands-on learning, and opportunities for advancement. Our people are our greatest investment, and we're proud to see team members grow with us.
If you're ready to use your talent to help deliver hope to patients around the world, join us - and be part of something bigger than yourself.
About The Role:
We are seeking a detail-oriented and highly motivated individual to join our GMP Manufacturing, Upstream team. As a Technician I, GMP Manufacturing - Upstream you will play a critical role in the production and cultivation of AAV-based gene therapy products in compliance with current Good Manufacturing Practices (cGMP) regulations. This position offers an exciting opportunity to contribute to the development and manufacturing of cutting-edge therapies that have the potential to transform the lives of patients.
Responsibilities:
  • Execute upstream manufacturing operations, including but not limited to cell culture expansion, transfection, and harvest steps, according to Standard Operating Procedures (SOPs) and batch records.
  • Prepare and operate bioreactors, centrifuges, filtration systems, and other equipment required for upstream processing, ensuring they are properly calibrated and maintained.
  • Perform media and buffer preparation, as well as the aseptic transfer of materials, adhering to cGMP guidelines and maintaining a clean and organized work area.
  • Monitor critical process parameters during manufacturing operations and report any deviations or abnormalities to the supervisor in a timely manner.
  • Conduct sampling and in-process testing, such as cell counts, viability, and metabolite analysis, to ensure optimal culture conditions and product quality.
  • Document all manufacturing activities, data, and results accurately and in compliance with cGMP regulations and company policies.
  • Collaborate with cross-functional teams, including Quality Assurance (QA) and Quality Control (QC), to investigate and resolve deviations, non-conformances, and quality incidents related to upstream manufacturing processes.
  • Participate in process improvement initiatives and support the implementation of new technologies, equipment, and methods to enhance manufacturing efficiency and productivity.
  • Follow safety procedures and adhere to environmental health and safety guidelines to maintain a safe working environment.
  • Participate in training programs and stay updated with current industry trends, regulatory requirements, and advancements in gene therapy manufacturing processes.

Qualifications:
  • Associate's or Bachelor's degree in a scientific field, or relevant industry certifications; or high school diploma with +2 years of related experience.
  • Previous experience working in a regulated manufacturing or laboratory environment.
  • Excellent organizational skills and the ability to multitask in a fast-paced environment while adhering to strict timelines.
  • Good interpersonal and communication skills, both written and verbal, to effectively collaborate with team members and stakeholders.
  • Commitment to following SOPs, safety protocols, and regulatory guidelines to ensure compliance and product quality.
  • Strong problem-solving skills and ability to identify and escalate issues as needed.
  • Ability to adapt to changing priorities and work independently as well as part of a team.
  • Flexibility to work in shifts, including weekends and holidays, as required by manufacturing production schedules.
  • Ability to stand for extended periods, and work in a cleanroom environment while wearing appropriate gowning and PPE.

Preferred Skills:
  • Prior experience working in a cGMP manufacturing environment.
  • Upstream bioprocessing or biologics manufacturing experience.
  • Familiarity with cell culture techniques, bioreactors, centrifuges, and filtration systems
  • Basic understanding of viral vector-based gene therapy processes, principles, and quality requirements.

This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee. Duties, responsibilities and activities may change, or new ones may be assigned.
Work Environment and Physical Demands
This position is performed in a temperature-controlled laboratory or office environment and requires regular standing, hand manipulation, and use of laboratory equipment. The role may involve lifting or moving materials up to 25 pounds and occasional reaching or handling at various heights. Appropriate personal protective equipment (PPE) must be worn when working with chemicals, biological materials, or in controlled environments.
Forge Biologics is an equal opportunity employer dedicated to building an inclusive and diverse workforce. Forge Biologics, provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.
We've Got You Covered:
At Forge Biologics, we believe our people deserve to be taken care of - in and out of the workplace. We've built a comprehensive compensation and benefits package designed to help you thrive, grow, and feel valued every step of the way:
Health from day one
  • Health, dental and vision insurance start your first day - with 90% of premiums covered for you and your family.

Time to recharge
  • A competitive paid time off plan - because rest fuels innovation.
  • 12 weeks of fully paid parental leave so you can focus on family when it matters most.

Rewarding your impact
  • Annual bonus opportunities for all full-time team members.
  • 401(k) with company match to help you plan for the future.
  • Special employee discounts, including childcare and dependent care savings.

Your wellness, supported
  • Onsite fitness facility at The Hearth.
  • Mental health counseling and financial planning services through our Employee Assistance Program.
  • Employer-paid short and long-term disability coverage to protect your peace of mind.

Fuel for your workday
  • A fully stocked kitchen with free snacks and beverages - we keep you energized and ready for what's next.

Grow with us
  • Ongoing professional development resources, training, and mentorship programs to help you build your care and grow within Forge.

Apply