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Upstream Manufacturing Associate Jobs (NOW HIRING)

Parsan Wade Search Llc

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Manufacturing Associate Upstream (M-F Flex)

Tustin, CA · On-site

$20.52 - $27.35/hr

The Manufacturing Associate Upstream performs multiple aspects of cGMP contract cell culture manufacturing in a multi-product manufacturing facility, including, but not limited to production ...

Parsan Wade Search Llc

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Manufacturing Associate Upstream (M-F Flex)

Tustin, CA · On-site

$20.52 - $27.35/hr

The Manufacturing Associate Upstream performs multiple aspects of cGMP contract cell culture manufacturing in a multi-product manufacturing facility, including, but not limited to production ...

Forge Biologics

GMP Technician I, Upstream

Columbus, OH

$18.25 - $24.50/hr

... manufacturing processes. Qualifications: * Associate's or Bachelor's degree in a scientific field ... Upstream bioprocessing or biologics manufacturing experience. * Familiarity with cell culture ...

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How much do upstream manufacturing associate jobs pay per hour?

As of May 30, 2026, the average hourly pay for upstream manufacturing associate in the United States is $20.84, according to ZipRecruiter salary data. Most workers in this role earn between $16.35 and $23.32 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as an Upstream Manufacturing Associate, and why are they important?

To thrive as an Upstream Manufacturing Associate, you need a solid background in biology or biochemistry, familiarity with Good Manufacturing Practices (GMP), and typically a bachelor's degree in a scientific field. Experience with bioreactor operation, aseptic techniques, and process control systems such as DeltaV is often required. Strong attention to detail, teamwork, and effective communication are crucial soft skills in this role. These competencies ensure the consistent production of high-quality biological products and compliance with industry regulations in a fast-paced environment.

What are some common challenges faced by Upstream Manufacturing Associates, and how can they be successfully managed?

Upstream Manufacturing Associates often encounter challenges such as maintaining sterility in bioprocessing environments, troubleshooting equipment malfunctions, and adapting to rapidly changing production schedules. Successfully managing these challenges requires strict adherence to standard operating procedures (SOPs), strong attention to detail, and effective communication with cross-functional teams like quality assurance and process engineering. Proactively seeking feedback, participating in ongoing training, and staying organized can help associates stay ahead of potential issues and contribute positively to team goals.

What are Upstream Manufacturing Associates?

Upstream Manufacturing Associates are professionals who work in the early stages of biopharmaceutical production, primarily focusing on cell culture and fermentation processes. They are responsible for preparing and maintaining bioreactors, monitoring cell growth, and ensuring optimal conditions for producing biological products such as proteins or vaccines. Their role is crucial in setting the foundation for downstream purification and final product manufacturing. Upstream Manufacturing Associates often work in cleanroom environments and follow strict safety and quality protocols.

What is the difference between Upstream Manufacturing Associate vs Downstream Manufacturing Associate?

AspectUpstream Manufacturing AssociateDownstream Manufacturing Associate
Primary ResponsibilitiesBioreactor operation, cell culture, media preparationPurification, filtration, packaging of products
Work EnvironmentCleanroom, laboratory, manufacturing floorCleanroom, laboratory, manufacturing floor
Required SkillsBioprocessing, sterile techniques, equipment handlingFiltration, chromatography, aseptic processing
CertificationsGMP training, sterile technique certificationGMP training, sterile technique certification

Both roles are essential in biopharmaceutical manufacturing, with upstream associates focusing on the early stages of production like cell culture, and downstream associates handling product purification and finishing. They often work in similar environments and require comparable certifications, but their specific tasks differ within the manufacturing process.

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Upstream Manufacturing Associate jobs near you
Infographic showing various Upstream Manufacturing Associate job openings in the United States as of May 2026, with employment types broken down into 84% Full Time, 8% Temporary, and 8% Contract. Highlights an 100% In-person job distribution, with an average salary of $43,341 per year, or $20.8 per hour.

Senior Manufacturing Associate, Upstream - 3rd Shift

ZYLIDAC BIO LLC

Emeryville, CA • On-site

$35 - $50/hr

Full-time

Posted yesterday

Job description

Description:
  • Assist in the creation of the Bill of Materials for the upstream process.
  • Assist in development and creation of the upstream process.
  • Monitor upstream operations (including trouble shooting and diagnosis of instruments, equipment, process, etc.)
  • Set-up, prepare, and operate manufacturing equipment/labware/assemblies (includes scaleup, bioreactors, harvest filtration including centrifugation, autoclave/sterilizer, bench top meters (pH/conductivity/osmometer), etc.) in accordance with current good manufacturing practices (cGMP).
  • Based on business needs there will be some cross training to support upstream operations (includes filtration skid, chromatography skid, viral filtration skid, TFF skid, Bulk fill, Freeze/Thaw, etc.) in accordance with current good manufacturing practices (cGMP).
  • Record and document procedures with detail and accuracy. This includes batch records, training records, logbooks, standard operating procedures (SOPs) and validation protocols.
  • Execute quality systems (including critical work orders, document change requests, change control, deviations, corrective action preventative action (CAPA)).
  • Create and revise standard operating procedures, batch records, part numbers, specifications, etc.
  • Weigh and prepare culture media, feeds, buffers, and solutions.
  • Coordination and collaboration of activities with other departments, and with external vendors.
  • Sample solutions and perform analytical assays (including cell counts, pH, conductivity, etc.)
  • Perform technical training for staff (including hands-on and class-based training)
  • Assist CMC team with technical transfer activities.
  • Identify and implement equipment and process improvements.
  • Maintain clean room work areas (including floors, benches, bioreactors, chromatography skids, etc.) waste disposal, lean manufacturing and good manufacturing practices (GMP)/compliance.
Requirements:
  • 4 years of college science in Cell Biology, Biochemistry, Chemistry, Biology, with 2 to 4 years of related experience.
  • Or 4 to 8 years of experience and/or training, or equivalent combination of education and experience.
  • Proficiency of upstream equipment (scaleup, bioreactors, harvest filtration, flow/UV/pH/conductivity/etc. sensors), filtration equipment, solution preparation equipment (laminar air flow hood, agitator mixers, bench top instruments) are essential for this position.
  • Attention to detail and accurate record keeping and documentation is mandatory in this position.
  • Teamwork and communication are key attributes needed for this position. A collaborative attitude and a positive work ethic are key traits for success.
  • Flexible work hours as business requires.