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Upstream Manufacturing Associate Jobs in Indiana

AK Steel

Coordinate activities with upstream and downstream operations, contractors, and support groups to ... Associate degree in a technical, manufacturing, business, or related field; or equivalent ...

Walker Transport

Quality Inspector

Lafayette, IN

The inspector communicated repeat defects effectively upstream, including escalation of events to ... Utilize control plans to aid in manufacturing of quality products to meet customer requirements.

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All JobsUpstream Manufacturing Associate JobsUpstream Manufacturing Associate Jobs in Indiana

Upstream Manufacturing Associate information

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$31

How much do upstream manufacturing associate jobs pay per hour?

As of Aug 23, 2026, the average hourly pay for upstream manufacturing associate in Indiana is $19.83, according to ZipRecruiter salary data. Most workers in this role earn between $15.58 and $22.21 per hour, depending on experience, location, and employer.

What is an upstream manufacturing associate?

Upstream Manufacturing Associates are professionals who work in the early stages of biopharmaceutical production, primarily focusing on cell culture and fermentation processes. They are responsible for preparing and maintaining bioreactors, monitoring cell growth, and ensuring optimal conditions for producing biological products such as proteins or vaccines. Their role is crucial in setting the foundation for downstream purification and final product manufacturing. Upstream Manufacturing Associates often work in cleanroom environments and follow strict safety and quality protocols.

What skills and qualifications are needed to be an upstream manufacturing associate?

To thrive as an Upstream Manufacturing Associate, you need a solid background in biology or biochemistry, familiarity with Good Manufacturing Practices (GMP), and typically a bachelor's degree in a scientific field. Experience with bioreactor operation, aseptic techniques, and process control systems such as DeltaV is often required. Strong attention to detail, teamwork, and effective communication are crucial soft skills in this role. These competencies ensure the consistent production of high-quality biological products and compliance with industry regulations in a fast-paced environment.

What challenges do upstream manufacturing associates face and how can they be managed?

Upstream Manufacturing Associates often encounter challenges such as maintaining sterility in bioprocessing environments, troubleshooting equipment malfunctions, and adapting to rapidly changing production schedules. Successfully managing these challenges requires strict adherence to standard operating procedures (SOPs), strong attention to detail, and effective communication with cross-functional teams like quality assurance and process engineering. Proactively seeking feedback, participating in ongoing training, and staying organized can help associates stay ahead of potential issues and contribute positively to team goals.

What is the difference between Upstream Manufacturing Associate vs Downstream Manufacturing Associate?

AspectUpstream Manufacturing AssociateDownstream Manufacturing Associate
Primary ResponsibilitiesBioreactor operation, cell culture, media preparationPurification, filtration, packaging of products
Work EnvironmentCleanroom, laboratory, manufacturing floorCleanroom, laboratory, manufacturing floor
Required SkillsBioprocessing, sterile techniques, equipment handlingFiltration, chromatography, aseptic processing
CertificationsGMP training, sterile technique certificationGMP training, sterile technique certification

Both roles are essential in biopharmaceutical manufacturing, with upstream associates focusing on the early stages of production like cell culture, and downstream associates handling product purification and finishing. They often work in similar environments and require comparable certifications, but their specific tasks differ within the manufacturing process.

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What job categories do people searching Upstream Manufacturing Associate jobs in Indiana look for?

The top searched job categories for Upstream Manufacturing Associate jobs in Indiana are:

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Upstream Manufacturing Associate jobs near you

Sr/Principal Scientist - Upstream Process Development

Genezen

Indianapolis, IN

Full-time

Re-posted 9 days ago

Job description

JOB SUMMARY

The Sr./Principal Scientist, Upstream Process Development will be part of the Process Development Group reporting to the Director of Process Development. The role will have direct management responsibility for a team of Scientists and Research Associates. The Sr/Principal Scientist is responsible for the Upstream Process development, characterization, technology transfer and GMP manufacturing technical support. This individual will lead or contribute as a core member of various cross-functional teams, and interact extensively with other departments within Genezen, including Analytical Development, Manufacturing, Engineering, and MSAT. This is a client-facing position with regular interaction with our partners including external presentations, driving the technical discussion and program strategy.

JOB RESPONSIBILITIES

  • Provides technical oversight and strategic input for upstream viral vector drug substance development activities
  • Leads, proposes, manages, and coordinates activities on platform improvement/continuous projects in USP labs
  • Leads, manages, and supports late-stage development, by identifying tasks, planning, monitoring progress of deliverables, and in terms of protocol and report generation in areas such as scale-down model qualification, process characterization, and scale-down model process validation studies
  • Leads and supports technology transfer activities at pilot plant and when necessary, preforms experiments him/herself, focusing scale-up platform process at scale and process improvements implementation, process characterization at scale and bills of materials as well as sampling plans.
  • Provides MSAT and manufacturing technical Upstream SME support for process troubleshooting, manufacturing data analysis, root cause analysis, and deviations during GMP production, change controls, CAPAs, CCRs and other Quality Systems documentation as needed.
  • Designs and outlines experimental plans to meet the defined Genezen and client objective. Analyses and reviews experimental results and data.
  • Performs, optimizes, and maintains linear scale-down models. Writes, reviews, and approves electronic lab notebooks (ELNs) entries, experimental protocols, development reports, process descriptions, and scientific reports
  • Presents project progress and results internally to cross-functional teams and externally to clients/stakeholders
  • Maintains robust communication with all relevant functions that have an impact on or are impacted by Upstream Process Development
  • Coordinates and supervises the activities in the USP labs (with a team of engineers/ (Jr.) bioprocess technologist, co-op students, interns, temporary personnel (contractors), and technical SMEs and when necessary, performs experiments him/herself. Guides junior USP team members by setting goals/tasks on projects

SPECIAL JOB REQUIREMENTS

  • Adaptability required as work schedule may change based on business needs
  • Criminal background check required
  • Other duties as assigned

KNOWLEDGE, SKILLS AND EXPERIENCE

EDUCATION / CERTIFICATIONS / LICENSES

Essential/Desired

MSc with 8+ years of relevant work experience in Bioprocess Engineering/ Life Science Biotechnology/Biochemistry/ Protein Chemistry, Chemical Engineering or related disciplines

Essential

PhD with 6+ years of relevant work experience in Bioprocess Engineering/ Life Science Biotechnology/Biochemistry/ Protein Chemistry, Chemical Engineering or related disciplines

Desired

ON-THE-JOB EXPERIENCE

 

Process Development and Cell Line Development Experience

Essential

Upstream Processing Experience with Cell Culture, Bioreactor Technologies, and Transfection/Infection approaches

Essential

Prior work experience at a CDMO 

Desired

SKILLS / ABILITIES

 

Hands-on experience on complex biologics, e.g. gene therapy, viral vaccines, therapeutic proteins

Essential

Experience with technology transfer and GMP manufacturing technical support

Essential

Experience with EMA/FDA regulations, ICH guidelines, GMP and quality systems

Essential

Effective communicator with track record of presenting data to relevant stakeholders including external stakeholders

Essential

Experience with DoE design and statistical analysis on large data sets

Essential

Excellent scientific writing skills demonstrated by publications and reports

Essential

Experience with direct management of Scientists and Research Associates including day-to-day oversight and direction and career development and coaching.

Essential

PHYSICAL DEMANDS 

While performing the duties of this job, the employee is required to meet the following physical demands:

Work Environment

  • Regularly sit for long periods of time

Movement

  • Frequently required to stand; sit; use hands to finger, handle, or feel; reach with hands and arms
  • Occasionally required to walk; climb or balance; and stoop, kneel, crouch, or crawl

Lifting

  • Frequently lift and/or move up to 10 pounds
  • Rarely lift and/or move up to 25 pounds

Vision

  • Frequently utilize close vision and the ability to adjust focus

Communication

  • Frequently required to communicate by talking, hearing, using telephone and e-mail

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