Trial Master File Jobs in Spring, TX (NOW HIRING)

Immaticsis committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting ofPRAME, a target expressed in more than 50 cancers. Ourcutting-edgescience and robust clinical pipeline form the broadestPRAMEfranchise with the mostPRAMEindications and modalities, spanning TCR T-cell therapies and TCRbispecifics.

Why Join Us?

• Innovative Environment:Helptopioneeradvancementsin cancer immunotherapy.

• Collaborative Culture:Be part ofa diverse team dedicated to your professionalgrowth.

• Global Impact:Contributeto therapies thatmakealasting impactonpatientsglobally.

Role Overview:

We are seeking a Senior Clinical Research Associate (CRA) to support our Clinical Operations team. The Senior CRA willbe responsible foroverseeing clinical trial site management and monitoring activities to ensure compliance with ICH-GCP, regulatory requirements, and company SOPs. In this role, you will partner closely with clinical sites and cross-functional teams to support high-quality study execution, patient recruitment, and operational excellence across clinical trials.

Reports to: Director, Team Lead Site Operations

Location:FullyRemote

Salary Range:$120,000 to $135,000

Basic Qualifications:

• Bachelor's degree in life sciences, nursing, or a related field

• 4+ years of on-site monitoring experience within the pharmaceutical or biotechnology industry, including all clinical monitoring visit types

• Strong knowledge of ICH-GCP, FDA, EMA, and applicable clinical trial regulations

• Demonstrated experience managing clinical trial sites,monitoringactivities, and clinical trial documentation

• Proficiencywith clinical trial systems and tools (e.g., CTMS, eTMF, Microsoft Office)

PreferredQualifications:

• Experience in oncology clinical trials or related therapeutic areas

• Advanced presentation, organizational, and stakeholder management skills

• Experience mentoring or training junior CRAs and supporting cross-functional clinical operations activities

• Demonstrated ability to drive quality, efficiency, and continuous improvement initiatives in clinical operations

• Strong understanding of clinical trial recruitment strategies, data capture, and site engagement best practices

• Experience contributing to global harmonization, process optimization, or operational innovation initiatives

In thisrole youwill:

• Conduct all clinical monitoring activities, including site qualification, initiation, routine monitoring, and close-out visits

• Support site feasibility, siteselection, and ongoing site management activities throughout the clinical trial lifecycle

• Review clinical trial progress, patient recruitment, and data quality metrics, and implement actions to support study objectives

• Maintainaccurateandtimelymonitoring documentation, including trip reports and trial master file records

• Collaborate with vendors, clinical sites, and cross-functional teams to support study execution and operational compliance

• Participate in investigator meetings, clinical trial documentation development, and study team meetings

• Mentor junior CRA team members and contribute to continuous improvement of clinical operations processes and procedures

Travel required:Willingness to travel up to 75%. Valid Driver's License preferable.

Qualified candidates willparticipatein a structured interview process, which includes:

• An initialrecruiter phone screen (conducted via video)

• A recruiter-facilitated introduction and interview with the hiring leader and key stakeholders (via video)

• A final-stage interview, which may include an in-person meeting at our U.S. Headquarters in Houston, TX

What do we offer?

AtImmatics, we believe in investing in our team's health,safetyand well-being.Here'swhat you can expectif youjoinImmatics

Comprehensive Benefits:

• Competitive rates forHealth, Dental, and Vision Insurance

• 4 weeks ofvacation,granted up front each year and prorated for firstand lastyear ofemployment.

• 12 company paid holidays

• 7daysof sick time

• 100%employer-paidlifeinsuranceup toat 1x annual salary, up to one hundred thousand dollars

• 100%employer-paidshort- andlong-Termdisabilitycoverage

• 401(k) withimmediateeligibilityandcompany match...

  • The company will match100% of your contributions upto3% of yourbase salaryfor the first two yearsof employment, 4% foryears 2-3 of employment, and up to5%of your salaryfrom the fourth year onward of continued employment.

• Partiallypaidparentalleavefor eligible employees.

• Additionalvoluntary employee-paidbenefits and services,includingaccident,hospitalindemnity, andcriticalillnessinsurance, as well as identitytheftprotection andpetinsurance.