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Staff Software Engineer Remote Jobs in Boston, MA

Asimov

Staff Software Engineer

Boston, MA · Remote

$179K - $230K/yr

We're looking for a Staff Software Engineer to help us build it. You'll join an interdisciplinary team that works directly with scientists, synthetic biologists, and computational biologists ...

Interra Health

Staff Software Engineer

Boston, MA · Remote

$151K - $200K/yr

The Role: As a Staff Software Engineer, you will play a critical role in advancing the Arrive ... Fully remote role within the United States * Periodic travel (approximately 5%) for team meetings ...

Chewy

Staff Software Engineer - Vet Care

Boston, MA · On-site +1

Our Opportunity Chewy is seeking a Staff Software Engineer to lead the Practice Hub engineering team, part of the Vet Clinics organization. The Practice Hub tech team is focused on building scalable ...

WEX

Staff Software Development Engineer, Web

Boston, MA · On-site +1

This is a remote position; however, the candidate must reside within 30 miles of one of the ... Seattle, WA; and Portland, ME About the Team/Role We're looking for a Staff software engineer with ...

SmithRx

Senior Staff Software Engineer, Platform

Boston, MA · On-site +1

$133K - $175K/yr

As a Staff Software Engineer, you will play a key role in the entire engineering lifecycle from ... US - Remote Compensation & Benefits * Base Salary: The range listed above reflects our standard pay ...

Architect.io

Senior Software Engineer (Remote)

Boston, MA · Remote

$125K - $165K/yr

We're poised for rapid growth, and this is the perfect opportunity to join our team and build the future of DevOps! Software engineering @ Architect.io We are seeking a Senior Software Engineer to ...

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All JobsStaff Software Engineer JobsStaff Software Engineer Remote JobsStaff Software Engineer Remote Jobs in Boston, MA

Staff Software Engineer Remote information

See Boston, MA salary details

$65.7K

$175.1K

$239K

How much do staff software engineer remote jobs pay per year?

As of Jul 30, 2026, the average yearly pay for staff software engineer remote in Boston, MA is $175,071.00, according to ZipRecruiter salary data. Most workers in this role earn between $146,100.00 and $207,000.00 per year, depending on experience, location, and employer.

How does a Staff Software Engineer collaborate with cross-functional teams in a remote environment?

As a Staff Software Engineer working remotely, you'll frequently collaborate with product managers, designers, QA engineers, and other software engineers through virtual meetings, shared documentation, and collaboration tools like Slack or Jira. Effective communication and clear documentation are essential to align on project goals, technical decisions, and timelines. You'll also mentor junior team members and often participate in architectural reviews, ensuring that distributed teams remain cohesive and productive despite working from different locations.

What is a Staff Software Engineer (Remote)?

A Staff Software Engineer (Remote) is a senior-level software engineer who works primarily from a location outside of the main office, often from home or another remote setting. This role typically involves leading technical projects, mentoring junior engineers, making architectural decisions, and collaborating with cross-functional teams to deliver high-quality software solutions. Staff Software Engineers are expected to have extensive experience in software development, strong problem-solving skills, and the ability to work independently as well as part of a distributed team. Remote staff engineers also leverage digital communication and collaboration tools to stay connected and productive.

What are the key skills and qualifications needed to thrive as a Staff Software Engineer (Remote), and why are they important?

To thrive as a Staff Software Engineer (Remote), you need advanced programming skills, deep architectural knowledge, and significant experience in software development, often backed by a bachelor's or master's degree in computer science or a related field. Expertise with programming languages like Java, Python, or Go, familiarity with cloud platforms (AWS, Azure, GCP), and proficiency in version control systems (e.g., Git) are typically required. Outstanding communication, leadership, and problem-solving abilities help you mentor teams and drive complex projects to completion. These skills ensure you can design robust systems, guide engineering teams remotely, and deliver scalable solutions in a distributed work environment.

What is the difference between Staff Software Engineer Remote vs Staff Software Engineer on-site?

AspectStaff Software Engineer RemoteStaff Software Engineer on-site
Work EnvironmentWorks remotely, often from home or co-working spacesWorks at company office location
Required CredentialsTypically requires similar technical skills and experience as on-site roles, including advanced software development expertiseSame credential requirements as remote roles, focusing on software engineering proficiency
Industry UsageCommon in tech companies supporting remote work policiesTraditional in many industries with physical office presence
Search & Comparison IntentOften searched by candidates seeking flexible work optionsOften searched by those preferring or needing on-site work

Both remote and on-site Staff Software Engineer roles require advanced technical skills and experience. The main difference lies in the work environment, with remote roles offering flexibility to work from anywhere, while on-site roles require physical presence at the company's location. Employers in tech industries increasingly support remote work, making both options viable for experienced software engineers.

What are popular job titles related to Staff Software Engineer Remote jobs in Boston, MA? For Staff Software Engineer Remote jobs in Boston, MA, the most frequently searched job titles are:
What job categories do people searching Staff Software Engineer Remote jobs in Boston, MA look for? The top searched job categories for Staff Software Engineer Remote jobs in Boston, MA are:
Staff Software Engineer Remote jobs near you
Infographic showing various Staff Software Engineer Remote job openings in Boston, MA as of July 2026, with employment types broken down into 89% Full Time, 8% Part Time, and 3% Contract. Highlights an 87% Physical, 4% Hybrid, and 9% Remote job distribution, with an average salary of $175,071 per year, or $84.2 per hour.

Staff Software Engineer

Asimov

Boston, MA • Remote

$179K - $230K/yr

Full-time

Re-posted 27 days ago

Job description

Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform––from cells to software––to enable the design and manufacture of next-generation therapeutics.

What would software engineering be like without an IDE? How could humans design a modern plane without CAD? Genetic engineering will be even more demanding—and we're building the tools to make it possible. Kernel is our platform for bioengineers to design, build, and debug genetic systems as confidently as we ship code. We're looking for a Staff Software Engineer to help us build it.

You'll join an interdisciplinary team that works directly with scientists, synthetic biologists, and computational biologists alongside your teammates in software engineering and product.

About the Role:

  • Make architectural decisions that will shape Kernel for years, with real ownership over how the system evolves.

  • Design GraphQL APIs for searching, editing and analyzing tens of thousands of genetic constructs using Python 3, SQLAlchemy and Strawberry.

  • Architect data models that represent the genuine complexity of biological systems.

  • Interface directly with synthetic biologists to understand their workflows and identify tools that would transform their productivity.

  • Be part of an on-call rotation to support the software you’ve helped develop.

About You:

  • You have 10+ years building production software - systems that other engineers depend on, not research code that runs once.

  • You have deep expertise in Python 3, and ideally with GraphQL, SQLAlchemy, and/or Strawberry. 

  • You’re the kind of engineer who loses track of time working on an interesting technical problem. You want challenges that will have you waking up with a new idea that you can’t wait to try.

  • You think about API design, data migrations, and what happens when the system has 10x usage.

  • You want to help design a product with a close-knit team, not just write code from predefined specifications. You can navigate the ambiguity of building something first-of-its-kind.

We're fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.

Compensation Range: $179K - $230K