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How much do single molecule microscopy jobs pay per year?

As of Jun 8, 2026, the average yearly pay for single molecule microscopy in the United States is $106,012.00, according to ZipRecruiter salary data. Most workers in this role earn between $104,000.00 and $104,000.00 per year, depending on experience, location, and employer.

What is single molecule microscopy?

Single molecule microscopy is an advanced imaging technique that allows scientists to observe and analyze individual molecules in real time, often within living cells. Unlike traditional microscopy, which looks at the collective behavior of many molecules, this method provides detailed insights into molecular interactions, dynamics, and functions at the single-molecule level. It is widely used in biophysics, chemistry, and cell biology to study processes such as protein folding, enzyme activity, and molecular transport. This technique requires highly sensitive equipment and specialized fluorescent labeling to detect and track single molecules with great precision.

What are the key skills and qualifications needed to thrive as a Single Molecule Microscopy Specialist, and why are they important?

To thrive in Single Molecule Microscopy, you need a strong background in physics, chemistry, or biology, typically with an advanced degree and experience in microscopy techniques. Familiarity with advanced fluorescence microscopy systems, data analysis software (such as ImageJ or MATLAB), and often certifications in laboratory safety are important. Attention to detail, problem-solving abilities, and effective communication help in troubleshooting experiments and collaborating with multidisciplinary teams. These skills are essential for generating accurate data, driving scientific discovery, and ensuring the reliability of experimental results.

What is the difference between Single Molecule Microscopy vs Fluorescence Microscopist?

AspectSingle Molecule MicroscopyFluorescence Microscopist
Required CredentialsAdvanced microscopy training, possibly PhD in biology or physicsSimilar; microscopy experience, often with a background in biology or chemistry
Work EnvironmentResearch labs, academic institutions, biotech companiesResearch labs, hospitals, biotech firms
Industry UsageSpecialized research in molecular biology, biophysicsBroad applications in cell biology, medical research

Single Molecule Microscopy and Fluorescence Microscopist roles share similar credentials and work environments, but Single Molecule Microscopy focuses on observing individual molecules, requiring specialized techniques. Fluorescence Microscopists often work with broader fluorescence imaging, making the roles distinct yet related in microscopy expertise.

What are some common challenges faced by single molecule microscopy researchers, and how can they be addressed?

Single molecule microscopy researchers often encounter challenges such as minimizing background noise, achieving high-resolution imaging, and ensuring sample stability during prolonged observations. Addressing these issues typically involves optimizing sample preparation protocols, using advanced imaging techniques like Total Internal Reflection Fluorescence (TIRF) microscopy, and implementing robust data analysis tools. Collaborating closely with physicists, chemists, and bioinformaticians can also help troubleshoot technical hurdles and improve experimental outcomes.
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Single Molecule Microscopy jobs near you
Infographic showing various Single Molecule Microscopy job openings in the United States as of May 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $106,012 per year, or $51 per hour.
Postdoctoral Scholar

Postdoctoral Scholar

Oregon Health & Science University

Portland, OR • On-site

Full-time

Posted 16 days ago

Oregon Health & Science University rating

8.3

Company rating: 8.3 out of 10

Based on 90 frontline employees who took The Breakroom Quiz

94th of 534 rated colleges and universities

Job description

Department Overview

The Vollum Institute is a privately endowed research institute at Oregon Health & Science University dedicated to basic research that will lead to new treatments for neurological and psychiatric diseases. Vollum scientists have broad-ranging interests that coalesce around molecular neurobiology and cellular physiology. Their work has transformed the field of neuroscience and, in particular, have provided important advances in the study of synaptic transmission, neuronal development, neurotransmitter transporters, ion channels and the neurobiology of disease.

Function/Duties of Position

This position is full-time and the responsibilities are to conduct research exploring the structural and biophysical mechanisms of synaptic transmission by elucidating the structures of native neurotransmitter receptors or transporters, and their synapses, or elements of the auditory transduction complex, by single particle cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) studies, in combination with complementary biochemical experiments.

  • Planning, executing, and analyzing experiments for independent research project(s) using biochemical methods and single particle and tomographic cryo-EM methods to elucidate the structure(s) of the target molecule(s) and their organization.
  • Manuscript preparation for individual projects and assisting other lab members with manuscripts as needed.
  • Assisting the PI and other lab members with grant application (data acquisition, writing assistance, editing) as needed.
  • Traveling to national and international meetings to present on findings.
  • Helping to mentor and train junior members of the laboratory.
  • Other duties as assigned.
Required Qualifications
  • PhD in biochemistry and biophysics.
  • Structural studies of biological molecules using cryo-EM, x-ray crystallography or NMR, in addition to complimentary biochemical studies.
  • Knowledge of cryo-EM, x-ray crystallography, Linux or UNIX computer language, theories and practice, as well as skills related to recombinant DNA technology, protein expression and purification, and basic biochemical analysis, including SDS PAGE and protein chromatography.
Preferred Qualifications

  • In depth experience in single particle cryo-EM and experience with protein expression, purification and biochemical studies, as well as experience in writing manuscripts and preparing and giving presentations.

  • Substantial experience in the publication of own work, as first author, in peer-reviewed publications.

  • Knowledge and skills in the areas of electron microscopy, preparation of EM grids, use and knowledge of computer programs for single particle cryo-EM and knowledge of membrane protein expression and purification from mammalian, insect or bacterial cells, along with accompanying biochemical analysis.

  • Fluent English language skills for writing and speaking, as well as ability to draft manuscripts and prepare oral presentations.
Additional Details

Standard laboratory work, Monday - Friday, 9:00am - 5:00pm, flexible with some evenings/weekends as experiments demand.

Why apply to OHSU?We are Oregon's only public academic health center. In addition to caring for patients, we lead groundbreaking research. We also train the next generation of health care professionals. As Portland's largest employer, we give you opportunities to learn and advance in a system of hospitals and clinics across Oregon and Southwest Washington. All are welcome. OHSU welcomes people of all ages, ethnicities, genders, national origins, religions and sexual orientations. We are striving to build an anti-racist, multicultural institution and encourage people with diverse backgrounds to apply. To request reasonable accommodation, contact askhr@ohsu.eduEmployment Type: FULL_TIME

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About Oregon Health & Science University

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Oregon Health & Science University (OHSU) is a distinguished institution under the industry of higher education and healthcare, specifically in the field of medical science. Based in Portland, Oregon, US, it maintains a reputation for promoting research, teaching, patient care, and outreach. Established in 1887, OHSU has continually sought to redefine the parameters of healthcare delivery and biomedical discovery through its expansive catalog of programs and initiatives. A galvanizing mission drives OHSU: to improve the health and quality of life for all Oregonians through excellence, innovation, and leadership in health care, education, and research.

Industry

Colleges, universities, and professional schools

Company size

10,000+ Employees

Headquarters location

Portland, OR, US

Year founded

1887

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