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$142.5K

How much do single molecule microscopy jobs pay per year?

As of Aug 12, 2026, the average yearly pay for single molecule microscopy in the United States is $106,012.00, according to ZipRecruiter salary data. Most workers in this role earn between $104,000.00 and $104,000.00 per year, depending on experience, location, and employer.

What is single molecule microscopy?

Single molecule microscopy is an advanced imaging technique that allows scientists to observe and analyze individual molecules in real time, often within living cells. Unlike traditional microscopy, which looks at the collective behavior of many molecules, this method provides detailed insights into molecular interactions, dynamics, and functions at the single-molecule level. It is widely used in biophysics, chemistry, and cell biology to study processes such as protein folding, enzyme activity, and molecular transport. This technique requires highly sensitive equipment and specialized fluorescent labeling to detect and track single molecules with great precision.

What are the key skills and qualifications needed to thrive as a single molecule microscopy specialist, and why are they important?

To thrive in Single Molecule Microscopy, you need a strong background in physics, chemistry, or biology, typically with an advanced degree and experience in microscopy techniques. Familiarity with advanced fluorescence microscopy systems, data analysis software (such as ImageJ or MATLAB), and often certifications in laboratory safety are important. Attention to detail, problem-solving abilities, and effective communication help in troubleshooting experiments and collaborating with multidisciplinary teams. These skills are essential for generating accurate data, driving scientific discovery, and ensuring the reliability of experimental results.

What is the difference between Single Molecule Microscopy vs Fluorescence Microscopist?

AspectSingle Molecule MicroscopyFluorescence Microscopist
Required CredentialsAdvanced microscopy training, possibly PhD in biology or physicsSimilar; microscopy experience, often with a background in biology or chemistry
Work EnvironmentResearch labs, academic institutions, biotech companiesResearch labs, hospitals, biotech firms
Industry UsageSpecialized research in molecular biology, biophysicsBroad applications in cell biology, medical research

Single Molecule Microscopy and Fluorescence Microscopist roles share similar credentials and work environments, but Single Molecule Microscopy focuses on observing individual molecules, requiring specialized techniques. Fluorescence Microscopists often work with broader fluorescence imaging, making the roles distinct yet related in microscopy expertise.

What are some common challenges faced by single molecule microscopy researchers, and how can they be addressed?

Single molecule microscopy researchers often encounter challenges such as minimizing background noise, achieving high-resolution imaging, and ensuring sample stability during prolonged observations. Addressing these issues typically involves optimizing sample preparation protocols, using advanced imaging techniques like Total Internal Reflection Fluorescence (TIRF) microscopy, and implementing robust data analysis tools. Collaborating closely with physicists, chemists, and bioinformaticians can also help troubleshoot technical hurdles and improve experimental outcomes.
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What cities are hiring for Single Molecule Microscopy jobs? Cities with the most Single Molecule Microscopy job openings:
What states have the most Single Molecule Microscopy jobs? States with the most job openings for Single Molecule Microscopy jobs include:
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Single Molecule Microscopy jobs near you
Infographic showing various Single Molecule Microscopy job openings in the United States as of August 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $106,012 per year, or $51 per hour.

Instructor - Charles and Jane Pak Center for Mineral Metabolism and Clinical Research [Req#: 965721,

UT Southwestern Medical Center

Dallas, TX • On-site

Full-time

Posted 2 days ago

New

UT Southwestern rating

7.9

Company rating: 7.9 out of 10

Based on 152 frontline employees who took The Breakroom Quiz

108th of 887 rated healthcare providers

Job description

Description
The Levi laboratory in the Charles and Jane Pak Center for Mineral Metabolism and Clinical Research has an opening for an Instructor. The Levi lab's mission is to improve the lives of people living with skin and musculoskeletal injuries and diseases through rigorous science and compassion. Current projects in the Levi laboratory are related to the molecular biology behind tissue fibrosis and the repair and regeneration process in tendon, muscle, and bone. The laboratory integrates multiomics-based approaches with investigations of musculoskeletal development, homeostasis, repair, and regeneration. The laboratory uses transgenic animal models combined with bioinformatic approaches to understand the cell-cell interactions that occur within the stem cell niche under physiological conditions and strives to understand how these divergent signaling mechanisms may guide future therapeutic strategies to promote faithful repair of damaged tissue.
Qualifications
The Levi Lab is looking for an Instructor with an Osteosarcoma focus to join the team who is willing to commit to at least two years. The Instructor will support ongoing bench and animal work within the lab related to tendon injury/fibrosis, muscle injury/fibrosis or bone/tendon/muscle regeneration. Duties will include routine molecular bench work combined with the use of animal models (animal handling, injections, surgeries, sample collection) as well as downstream processing (histology, immunofluorescent stain and confocal imaging, flow cytometry, cell culture, single cell and bulk RNA sequencing) under supervision of the PI.
Candidates should hold a Ph.D. in Immunology, Cellular and Molecular Biology, Biochemistry, Genetics or other relevant branches of biological sciences, and at least two years of research and animal experience in a postdoctoral researcher position.
Laboratory Expectations
  • Routine molecular bench work combined with the use of animal models
  • Animal handling, injections, modified diet maintenance, surgeries, and sample collection
  • Downstream processing
  • Histology, immunofluorescent stain and confocal imaging, flow cytometry, and work with cell cultures and single-cell and bulk RNA sequencing

Preferred Experience
  • Able to utilize a variety of molecular biology techniques, including but not limited to PCR, qPCR, western blotting, RNA/DNA extraction, cloning, CRISPR/Cas9 gene editing, and next generation sequencing.
  • Experience with animal handling, animal breeding, genotyping, and animal surgery.
  • Experience with single-cell transcriptomic analyses.
  • Experience with histology pipeline from tissue harvest to embedding, sectioning, staining, and confocal microscopy.
  • Experience with flow cytometry and mass spectrometry.
  • Excellent written and oral communication and organizational skills.
  • Able to perform data analysis and interpretation using bioinformatics tools, statistical methods, and relevant software packages.

Laboratory Duties
  • Animal breeding, genotyping, handling, and surgery
  • Molecular biology techniques, including but not limited to PCR, qPCR, western blotting, RNA/DNA extraction, cloning, CRISPR/Cas9 gene editing, and next generation sequencing.
  • Flow cytometry and mass spectrometry.
  • Histology pipeline from tissue harvest to embedding, sectioning, staining, and confocal microscopy.
  • Design and execute experiments to investigate molecular mechanisms underlying biological processes.
  • Plan and develop standard operating protocols for experimental protocols.
  • Review and analyze resulting research data.
  • Revise techniques or approaches to work problems that are indicated as necessary by research data.
  • May confer with industrial, governmental, or other groups concerning progress or results of research project.
  • Maintain a respectful and inclusive laboratory environment.
  • Maintain a clean and functional workspace.
  • Analyze and interpret experimental data using relevant software and statistical methods.
  • Stay current with advances in molecular biology research and contribute to the development of new methodologies and techniques.
  • Prepare research findings for publication in scientific journals and present results at conferences and meetings, including weekly laboratory meetings and reading/writing clubs.
  • Contribute to grant writing and fundraising efforts to support research activities.
  • Collaborate with interdisciplinary teams to contribute molecular biology expertise to research projects and initiatives.
  • Assist in the training and supervision of junior laboratory personnel, including technicians, graduate students, and postdoctoral fellows.

Application Instructions
Application Instructions
  • Cover letter describing research interests and qualifications for the position.
  • Curriculum vitae (CV).

Applications should be submitted electronically through the UT Southwestern Careers website.

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