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Single Molecule Microscopy information

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$37K

$106K

$142.5K

How much do single molecule microscopy jobs pay per year?

As of Jul 3, 2026, the average yearly pay for single molecule microscopy in the United States is $106,012.00, according to ZipRecruiter salary data. Most workers in this role earn between $104,000.00 and $104,000.00 per year, depending on experience, location, and employer.

What is single molecule microscopy?

Single molecule microscopy is an advanced imaging technique that allows scientists to observe and analyze individual molecules in real time, often within living cells. Unlike traditional microscopy, which looks at the collective behavior of many molecules, this method provides detailed insights into molecular interactions, dynamics, and functions at the single-molecule level. It is widely used in biophysics, chemistry, and cell biology to study processes such as protein folding, enzyme activity, and molecular transport. This technique requires highly sensitive equipment and specialized fluorescent labeling to detect and track single molecules with great precision.

What are the key skills and qualifications needed to thrive as a Single Molecule Microscopy Specialist, and why are they important?

To thrive in Single Molecule Microscopy, you need a strong background in physics, chemistry, or biology, typically with an advanced degree and experience in microscopy techniques. Familiarity with advanced fluorescence microscopy systems, data analysis software (such as ImageJ or MATLAB), and often certifications in laboratory safety are important. Attention to detail, problem-solving abilities, and effective communication help in troubleshooting experiments and collaborating with multidisciplinary teams. These skills are essential for generating accurate data, driving scientific discovery, and ensuring the reliability of experimental results.

What is the difference between Single Molecule Microscopy vs Fluorescence Microscopist?

AspectSingle Molecule MicroscopyFluorescence Microscopist
Required CredentialsAdvanced microscopy training, possibly PhD in biology or physicsSimilar; microscopy experience, often with a background in biology or chemistry
Work EnvironmentResearch labs, academic institutions, biotech companiesResearch labs, hospitals, biotech firms
Industry UsageSpecialized research in molecular biology, biophysicsBroad applications in cell biology, medical research

Single Molecule Microscopy and Fluorescence Microscopist roles share similar credentials and work environments, but Single Molecule Microscopy focuses on observing individual molecules, requiring specialized techniques. Fluorescence Microscopists often work with broader fluorescence imaging, making the roles distinct yet related in microscopy expertise.

What are some common challenges faced by single molecule microscopy researchers, and how can they be addressed?

Single molecule microscopy researchers often encounter challenges such as minimizing background noise, achieving high-resolution imaging, and ensuring sample stability during prolonged observations. Addressing these issues typically involves optimizing sample preparation protocols, using advanced imaging techniques like Total Internal Reflection Fluorescence (TIRF) microscopy, and implementing robust data analysis tools. Collaborating closely with physicists, chemists, and bioinformaticians can also help troubleshoot technical hurdles and improve experimental outcomes.
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Single Molecule Microscopy jobs near you
Infographic showing various Single Molecule Microscopy job openings in the United States as of June 2026, with employment types broken down into 12% Locum Tenens, 17% Full Time, 5% Part Time, 10% Temporary, and 56% Contract. Highlights an 94% Physical, 2% Hybrid, and 4% Remote job distribution, with an average salary of $106,012 per year, or $51 per hour.
Postdoctoral Scholar

Postdoctoral Scholar

Oregon Health & Science University

Portland, OR

Full-time

Posted 11 days ago

Oregon Health & Science University rating

8.1

Company rating: 8.1 out of 10

Based on 94 frontline employees who took The Breakroom Quiz

134th of 544 rated colleges and universities

Job description

Department Overview

The Mansoor lab seeks a postdoctoral scholar who is interested in structural biology and drug development. The scholar will receive training in the expression and purification of membrane proteins for biophysical and structural analysis, specifically single particle cryogenic electron microscopy (Cryo-EM), as well as training in electrophysiology.

Applicants must be NIH training grant eligible (US Citizen or Green Card holder).

Applicants should send a cover letter describing research experience and interests, a CV, and contacts for references to Steven E. Mansoor (mansoors@ohsu.edu).

The Mansoor Lab studies the molecular structure and function of ion channels and receptors in the cardiovascular system to develop novel small molecules for the treatment of conditions such as hypertension, angina, and platelet aggregation. Typical techniques and experiments in the lab include, but are not limited to, molecular biology, tissue culture, electrophysiology experiments in both Xenopus oocytes and mammalian cells, and protein expression and purification preparations to get isolated receptor for structural studies, including both X-ray crystallography as well as single particle cryogenic electron microscopy. Applicants must have prior biochemistry and molecular biology experience and be comfortable with these types of experiments. Preference will be given to applicants with previous training in membrane protein biochemistry, X-ray crystallography and/or cryogenic electron microscopy.

Function/Duties of Position
  • Primary Research (including planning, granting, execution, analysis, publication)
  • a. Maintain laboratory compliance documentation for human, animal, biological and radiological work.  b. Be familiar with lab safety infrastructure and ensure compliance with all safety regulations.c. Interact with biosafety, chemical safety, and safety officers on behalf of the Principal Investigator.
  • a. Generate data and research analysis for investigator's use in preparation of technical reports and publications.b. Assist the PI with manuscript preparation and grant applications.c. Present, or assist in the presentation of, research projects at retreats, seminars, conferences and other OHSU or public venues.
  • Providing training to users on lab practices and protocols, including sample preparation and instrumentation use.
  • Maintain an accurate and detailed laboratory notebook of all experiments performed. Participate in lab meeting.
  • Training of lab personnel and supervision of Research Assistants, students and other lab members.
  • Perform routine lab operations, including but not limited to the purchase of laboratory supplies, monitoring supplies and maintaining all laboratory equipment.
  • Other responsibilities as assigned by the supervisor in furtherance of the lab's research and the university's missions and goals of teaching, research, patient care, outreach and public service.
    • Required Qualifications
    • PhD in biological sciences or a related field
    • Experimental design and interpretation of results
    • Basic molecular biological methods of DNA manipulation and analysis
    • Gene analysis techniques
    • Basic protein analysis techniques such as western blots, immunoprecipitation and immunostaining skills, mammalian cell culture
    • Strong organizational and interpersonal skills
    • Strong scientific curiosity, problem-solving skills and research integrity
    • High attention to detail and accuracy
    • Demonstrated success working independently and as a member of a collaborative team
    • Ability to communicate effectively, in both written and oral formats
    • Working knowledge of office computer applications, such as Word, Excel and PowerPoint
    Preferred Qualifications
    • PhD in Biochemistry or Biophysics/Physics
    • Experience identifying, manipulating, or using nucleic acid aptamers, ideally from de novo selection by SELEX

    • SELEX, nucleic acid and protein purification, chromatography, biophysical binding analysis, analytical biochemistry

      • Programming using Unix

      • Knowledge of membrane protein biochemistry.

    Additional Details

    Position is located at the OHSU Marquam Hill campus in Portland, Oregon.  The work schedule will be set by the supervising faculty, dictated by the needs of the research and planned experiments.  Working evenings, weekends and extended hours may be required depending on the needs of the research.  Work environment is in an open wet lab, in the presence of laboratory chemicals and automated equipment.

    Employee will need to work at lab benches, desks and/or microscopes for up to 8 hours at a time. Ability to perform repetitive lab manipulations (gripping, grasping, reaching, twisting), move lab equipment up to 50 lbs with accommodation, perform image analysis operation and help others with equipment use. Personal protective equipment must be worn as required. (Gloves, mask/respirator, eyewear, lab coat, etc.) Willing to work with radioactive materials, recombinant viruses, and possibly small animals such as mice and rats.

    Must be able to communicate orally and in writing the results of scientific experiments; must be able to use a standard computer and screen up to 6 hours per day.

    Why apply to OHSU?We are Oregon's only public academic health center. In addition to caring for patients, we lead groundbreaking research. We also train the next generation of health care professionals. As Portland's largest employer, we give you opportunities to learn and advance in a system of hospitals and clinics across Oregon and Southwest Washington. All are welcome. OHSU welcomes people of all ages, ethnicities, genders, national origins, religions and sexual orientations. We are striving to build an anti-racist, multicultural institution and encourage people with diverse backgrounds to apply. To request reasonable accommodation, contact askhr@ohsu.eduEmployment Type: FULL_TIME

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    About Oregon Health & Science University

    Sourced by ZipRecruiter

    Oregon Health & Science University (OHSU) is a distinguished institution under the industry of higher education and healthcare, specifically in the field of medical science. Based in Portland, Oregon, US, it maintains a reputation for promoting research, teaching, patient care, and outreach. Established in 1887, OHSU has continually sought to redefine the parameters of healthcare delivery and biomedical discovery through its expansive catalog of programs and initiatives. A galvanizing mission drives OHSU: to improve the health and quality of life for all Oregonians through excellence, innovation, and leadership in health care, education, and research.

    Industry

    Colleges, universities, and professional schools

    Company size

    10,000+ Employees

    Headquarters location

    Portland, OR, US

    Year founded

    1887

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