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Single Molecule Microscopy Jobs (NOW HIRING)

The Ohio State University

Post Doctoral Scholar

Columbus, OH · On-site

$44K - $60K/yr

... microscopy and spectroscopy experiments, including sample preparation protocols and benchmarking of optical spectrometers and anti-Brownian traps designed for single-particle and single-molecule ...

The Pennsylvania State University

The position requires a PhD in Chemistry (or an equivalent doctorate in an appropriate field) with a focus on cryogenic electron microscopy (Cryo-EM) and/or single molecule optical tweezers ...

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Single Molecule Microscopy information

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$37K

$106K

$142.5K

How much do single molecule microscopy jobs pay per year?

As of Sep 3, 2026, the average yearly pay for single molecule microscopy in the United States is $106,012.00, according to ZipRecruiter salary data. Most workers in this role earn between $104,000.00 and $104,000.00 per year, depending on experience, location, and employer.

What is single molecule microscopy?

Single molecule microscopy is an advanced imaging technique that allows scientists to observe and analyze individual molecules in real time, often within living cells. Unlike traditional microscopy, which looks at the collective behavior of many molecules, this method provides detailed insights into molecular interactions, dynamics, and functions at the single-molecule level. It is widely used in biophysics, chemistry, and cell biology to study processes such as protein folding, enzyme activity, and molecular transport. This technique requires highly sensitive equipment and specialized fluorescent labeling to detect and track single molecules with great precision.

What are some common challenges faced by single molecule microscopy researchers, and how can they be addressed?

Single molecule microscopy researchers often encounter challenges such as minimizing background noise, achieving high-resolution imaging, and ensuring sample stability during prolonged observations. Addressing these issues typically involves optimizing sample preparation protocols, using advanced imaging techniques like Total Internal Reflection Fluorescence (TIRF) microscopy, and implementing robust data analysis tools. Collaborating closely with physicists, chemists, and bioinformaticians can also help troubleshoot technical hurdles and improve experimental outcomes.

What are the key skills and qualifications needed to thrive as a single molecule microscopy specialist, and why are they important?

To thrive in Single Molecule Microscopy, you need a strong background in physics, chemistry, or biology, typically with an advanced degree and experience in microscopy techniques. Familiarity with advanced fluorescence microscopy systems, data analysis software (such as ImageJ or MATLAB), and often certifications in laboratory safety are important. Attention to detail, problem-solving abilities, and effective communication help in troubleshooting experiments and collaborating with multidisciplinary teams. These skills are essential for generating accurate data, driving scientific discovery, and ensuring the reliability of experimental results.

What is the difference between Single Molecule Microscopy vs Fluorescence Microscopist?

AspectSingle Molecule MicroscopyFluorescence Microscopist
Required CredentialsAdvanced microscopy training, possibly PhD in biology or physicsSimilar; microscopy experience, often with a background in biology or chemistry
Work EnvironmentResearch labs, academic institutions, biotech companiesResearch labs, hospitals, biotech firms
Industry UsageSpecialized research in molecular biology, biophysicsBroad applications in cell biology, medical research

Single Molecule Microscopy and Fluorescence Microscopist roles share similar credentials and work environments, but Single Molecule Microscopy focuses on observing individual molecules, requiring specialized techniques. Fluorescence Microscopists often work with broader fluorescence imaging, making the roles distinct yet related in microscopy expertise.

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Cities with the most Single Molecule Microscopy job openings:

What states have the most Single Molecule Microscopy jobs?

States with the most job openings for Single Molecule Microscopy jobs include:

What job categories do people searching Single Molecule Microscopy jobs look for?

The top searched job categories for Single Molecule Microscopy jobs are:

Single Molecule Microscopy jobs near you
Infographic showing various Single Molecule Microscopy job openings in the United States as of August 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $106,012 per year, or $51 per hour.

Post Doctoral Scholar

The Ohio State University

Columbus, OH • On-site

$44K - $60K/yr

Full-time

Re-posted 27 days ago

Job description

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Job Title:
Post Doctoral Scholar
Department:
Arts and Sciences | Chemistry and Biochemistry Administration
A postdoctoral researcher appointment is available in the Carpenter Spectroscopy Group (https://www.carpentergroup.site/) in the Department of Chemistry and Biochemistry at The Ohio State University. The postdoctoral researcher will perform independent experiments in single-molecule and single-particle optical spectroscopy, centered around the heterogeneity and chemical dynamics of biological nanocompartments. The researcher will work independently on research projects decided on jointly by the postdoctoral fellow and the PI and is expected to generate data and insights for scientific publication and presentation at professional meetings.
As a member of a recently established lab, duties will also consist of establishing single-particle microscopy and spectroscopy experiments, including sample preparation protocols and benchmarking of optical spectrometers and anti-Brownian traps designed for single-particle and single-molecule measurements. The individual will also assist with the general development of the lab, including assisting with funding proposals and mentoring graduate and undergraduate students in sample preparation protocols, optical techniques, data analysis, and scientific communication. Interested applicants should submit a CV and a cover letter that explains desired research direction.
Minimum Education Required
PhD in chemistry, physics, biomedical engineering, or other related discipline.
Required Qualifications
Past graduate or postdoctoral experience in spectroscopy and imaging in molecular systems, as demonstrated by scientific publications in the field. Required skills include operation and alignment of custom laser instrumentation, and programming experience in e.g. MATLAB/Python/LabVIEW for data analysis and software experimental control.
Also required are strong written and oral communications skills, interpersonal skills for collaborative science and mentorship, problem-solving skills, ability to learn new research techniques, and ability to generate new research ideas.
Additional Information:
The College of Arts and Sciences is the largest college and the academic heart of the university. The College hosts 81 majors. With 38 departments, 20+ world-class research centers, and more than 2,000 faculty and staff members, students have the unique opportunity to study with the best artists, scholars, and scientists in their field.
Location:
Newman and Wolfrom Laboratory of Chemistry (0147)
Position Type:
Term (Fixed Term)
Scheduled Hours:
40
Shift:
First Shift
Final candidates are subject to successful completion of a background check. A drug screen or physical may be required during the post offer process.
Thank you for your interest in positions at The Ohio State University and Wexner Medical Center. Once you have applied, the most updated information on the status of your application can be found by visiting the Candidate Home section of this site. Please view your submitted applications by logging in and reviewing your status. For answers to additional questions please review the frequently asked questions.
The university is an equal opportunity employer, including veterans and disability.

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