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Single Molecule Microscopy Jobs (NOW HIRING)

The Pennsylvania State University

The position requires a PhD in Chemistry (or an equivalent doctorate in an appropriate field) with a focus on cryogenic electron microscopy (Cryo-EM) and/or single molecule optical tweezers ...

Massgeneralbrigham

Research Lab Technician I

Boston, MA · On-site

$21 - $29.01/hr

... ultrasenstivie single molecule array (Simoa) and Molecular On-bead Signal Amplification for ... Coli, visualizing protein aggregates using fluorescence microscopy, and generating and developing ...

UCLA Health

Laboratory Technician 2

Los Angeles, CA · On-site

$26.23 - $30.93/hr

... single-cell and single-nucleus sequencing studies. The ideal candidate will possess strong ... Demonstrated skills in conventional and confocal microscopy * Demonstrated skills in molecular ...

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Single Molecule Microscopy information

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How much do single molecule microscopy jobs pay per year?

As of Jun 8, 2026, the average yearly pay for single molecule microscopy in the United States is $106,012.00, according to ZipRecruiter salary data. Most workers in this role earn between $104,000.00 and $104,000.00 per year, depending on experience, location, and employer.

What is single molecule microscopy?

Single molecule microscopy is an advanced imaging technique that allows scientists to observe and analyze individual molecules in real time, often within living cells. Unlike traditional microscopy, which looks at the collective behavior of many molecules, this method provides detailed insights into molecular interactions, dynamics, and functions at the single-molecule level. It is widely used in biophysics, chemistry, and cell biology to study processes such as protein folding, enzyme activity, and molecular transport. This technique requires highly sensitive equipment and specialized fluorescent labeling to detect and track single molecules with great precision.

What are the key skills and qualifications needed to thrive as a Single Molecule Microscopy Specialist, and why are they important?

To thrive in Single Molecule Microscopy, you need a strong background in physics, chemistry, or biology, typically with an advanced degree and experience in microscopy techniques. Familiarity with advanced fluorescence microscopy systems, data analysis software (such as ImageJ or MATLAB), and often certifications in laboratory safety are important. Attention to detail, problem-solving abilities, and effective communication help in troubleshooting experiments and collaborating with multidisciplinary teams. These skills are essential for generating accurate data, driving scientific discovery, and ensuring the reliability of experimental results.

What is the difference between Single Molecule Microscopy vs Fluorescence Microscopist?

AspectSingle Molecule MicroscopyFluorescence Microscopist
Required CredentialsAdvanced microscopy training, possibly PhD in biology or physicsSimilar; microscopy experience, often with a background in biology or chemistry
Work EnvironmentResearch labs, academic institutions, biotech companiesResearch labs, hospitals, biotech firms
Industry UsageSpecialized research in molecular biology, biophysicsBroad applications in cell biology, medical research

Single Molecule Microscopy and Fluorescence Microscopist roles share similar credentials and work environments, but Single Molecule Microscopy focuses on observing individual molecules, requiring specialized techniques. Fluorescence Microscopists often work with broader fluorescence imaging, making the roles distinct yet related in microscopy expertise.

What are some common challenges faced by single molecule microscopy researchers, and how can they be addressed?

Single molecule microscopy researchers often encounter challenges such as minimizing background noise, achieving high-resolution imaging, and ensuring sample stability during prolonged observations. Addressing these issues typically involves optimizing sample preparation protocols, using advanced imaging techniques like Total Internal Reflection Fluorescence (TIRF) microscopy, and implementing robust data analysis tools. Collaborating closely with physicists, chemists, and bioinformaticians can also help troubleshoot technical hurdles and improve experimental outcomes.
More about Single Molecule Microscopy jobs
What cities are hiring for Single Molecule Microscopy jobs? Cities with the most Single Molecule Microscopy job openings:
What states have the most Single Molecule Microscopy jobs? States with the most job openings for Single Molecule Microscopy jobs include:
What job categories do people searching Single Molecule Microscopy jobs look for? The top searched job categories for Single Molecule Microscopy jobs are:
Single Molecule Microscopy jobs near you
Infographic showing various Single Molecule Microscopy job openings in the United States as of May 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $106,012 per year, or $51 per hour.

Postdoctoral Scholar (Chemistry Department)

Penn State University

University Park, PA • On-site

$47K - $65K/yr

Full-time

Posted 5 days ago

Penn State University rating

7.9

Company rating: 7.9 out of 10

Based on 100 frontline employees who took The Breakroom Quiz

173rd of 534 rated colleges and universities

Job description

APPLICATION INSTRUCTIONS:
  • CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, apply internally through Workday.
  • CURRENT PENN STATE STUDENT (not employed previously at the university) and seeking employment with Penn State, please login to Workday to complete the student application process. Please do not apply here, apply internally through Workday.
  • If you are NOT a current employee or student, please click "Apply" and complete the application process for external applicants.

Approval of remote and hybrid work is not guaranteed regardless of work location. For additional information on remote work at Penn State, see Notice to Out of State Applicants.
This is a term position; length of the term will be discussed during the interview process. Continuation past the term length discussed will be based on university need, performance, and/or availability of funding.
POSITION SPECIFICS
The laboratory of Associate Professor Mark Hedglin in the Chemistry Department at The Pennsylvania State University seeks to fill a postdoctoral research position to work in the areas of molecular biology, biochemistry and biophysical chemistry.
The position requires a PhD in Chemistry (or an equivalent doctorate in an appropriate field) with a focus on cryogenic electron microscopy (Cryo-EM) and/or single molecule optical tweezers-fluorescence microscopy. Researchers with training/expertise in expressing and purifying recombinant proteins from the baculovirus/insect cell expression system are highly-preferred, but individuals trained in other methods of protein expression and purification are welcome to apply.
Interested and qualified applicants should submit applications electronically and include a CV with their research history and a complete list of publications. Following a screening of initial application materials, appropriate candidates will be contacted by email and asked to arrange for letters of recommendation to be sent so that they might be considered further.
Review of applications will begin immediately and continue until position is filled.
BACKGROUND CHECKS/CLEARANCES
Employment with the University will require successful completion of background check(s) in accordance with University policies.
BENEFITS
Penn State provides a competitive benefits package for full-time employees designed to support both personal and professional well-being.
For more detailed information, please visit our Benefits Page.
CAMPUS SECURITY CRIME STATISTICS
Pursuant to the Jeanne Clery Disclosure of Campus Security Policy and Campus Crime Statistics Act and the Pennsylvania Act of 1988, Penn State publishes a combined Annual Security and Annual Fire Safety Report (ASR). The ASR includes crime statistics and institutional policies concerning campus security, such as those concerning alcohol and drug use, crime prevention, the reporting of crimes, sexual assault, and other matters. The ASR is available for review here.
EEO IS THE LAW
Penn State is an equal opportunity employer and is committed to providing employment opportunities to all qualified applicants without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability or protected veteran status. If you are unable to use our online application process due to an impairment or disability, please contact 814-865-1473.
The Pennsylvania State University is committed to and accountable for advancing equity, respect, and belonging. We embrace individual uniqueness, as well as a culture of belonging that supports equity initiatives, leverages the educational and institutional benefits of inclusion in society, and provides opportunities for engagement intended to help all members of the community thrive. We value belonging as a core strength and an essential element of the university's teaching, research, and service mission.
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