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Single Molecule Microscopy Jobs (NOW HIRING)

The Pennsylvania State University

The position requires a PhD in Chemistry (or an equivalent doctorate in an appropriate field) with a focus on cryogenic electron microscopy (Cryo-EM) and/or single molecule optical tweezers ...

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Single Molecule Microscopy information

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$37K

$106K

$142.5K

How much do single molecule microscopy jobs pay per year?

As of Jul 24, 2026, the average yearly pay for single molecule microscopy in the United States is $106,012.00, according to ZipRecruiter salary data. Most workers in this role earn between $104,000.00 and $104,000.00 per year, depending on experience, location, and employer.

What is single molecule microscopy?

Single molecule microscopy is an advanced imaging technique that allows scientists to observe and analyze individual molecules in real time, often within living cells. Unlike traditional microscopy, which looks at the collective behavior of many molecules, this method provides detailed insights into molecular interactions, dynamics, and functions at the single-molecule level. It is widely used in biophysics, chemistry, and cell biology to study processes such as protein folding, enzyme activity, and molecular transport. This technique requires highly sensitive equipment and specialized fluorescent labeling to detect and track single molecules with great precision.

What are the key skills and qualifications needed to thrive as a Single Molecule Microscopy Specialist, and why are they important?

To thrive in Single Molecule Microscopy, you need a strong background in physics, chemistry, or biology, typically with an advanced degree and experience in microscopy techniques. Familiarity with advanced fluorescence microscopy systems, data analysis software (such as ImageJ or MATLAB), and often certifications in laboratory safety are important. Attention to detail, problem-solving abilities, and effective communication help in troubleshooting experiments and collaborating with multidisciplinary teams. These skills are essential for generating accurate data, driving scientific discovery, and ensuring the reliability of experimental results.

What is the difference between Single Molecule Microscopy vs Fluorescence Microscopist?

AspectSingle Molecule MicroscopyFluorescence Microscopist
Required CredentialsAdvanced microscopy training, possibly PhD in biology or physicsSimilar; microscopy experience, often with a background in biology or chemistry
Work EnvironmentResearch labs, academic institutions, biotech companiesResearch labs, hospitals, biotech firms
Industry UsageSpecialized research in molecular biology, biophysicsBroad applications in cell biology, medical research

Single Molecule Microscopy and Fluorescence Microscopist roles share similar credentials and work environments, but Single Molecule Microscopy focuses on observing individual molecules, requiring specialized techniques. Fluorescence Microscopists often work with broader fluorescence imaging, making the roles distinct yet related in microscopy expertise.

What are some common challenges faced by single molecule microscopy researchers, and how can they be addressed?

Single molecule microscopy researchers often encounter challenges such as minimizing background noise, achieving high-resolution imaging, and ensuring sample stability during prolonged observations. Addressing these issues typically involves optimizing sample preparation protocols, using advanced imaging techniques like Total Internal Reflection Fluorescence (TIRF) microscopy, and implementing robust data analysis tools. Collaborating closely with physicists, chemists, and bioinformaticians can also help troubleshoot technical hurdles and improve experimental outcomes.
More about Single Molecule Microscopy jobs
What cities are hiring for Single Molecule Microscopy jobs? Cities with the most Single Molecule Microscopy job openings:
What states have the most Single Molecule Microscopy jobs? States with the most job openings for Single Molecule Microscopy jobs include:
What job categories do people searching Single Molecule Microscopy jobs look for? The top searched job categories for Single Molecule Microscopy jobs are:
Single Molecule Microscopy jobs near you
Infographic showing various Single Molecule Microscopy job openings in the United States as of July 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $106,012 per year, or $51 per hour.
Biochemistry Researcher

Biochemistry Researcher

Colorado State University

Fort Collins, CO • On-site

Part-time

Posted 18 days ago

Colorado State University rating

6.7

Company rating: 6.7 out of 10

Based on 49 frontline employees who took The Breakroom Quiz

442nd of 560 rated colleges and universities

Job description

Job Description

Position Summary

Will performresearchin the lab to understand how disease-correlated mutations in genes are causative of so-called dyneinopathies.

Department Name

Biochemistry and Molecular Biology

Anticipated Start Date

July 10th, 2026

Anticipated Weekly Hours

20

Required JobQualifications

Must know how to purify dynein frombuddingyeast and perform single molecule motility assays using TIRF microscopy.

Preferred Job Qualifications

Existing knowledge that would permit them to dissect tetrads and perform genetic analysis of resulting progeny.

Essential Duties

Purify proteins, TIRF microscopy, grow/handle budding yeast.

Salary Range20.00Required Application Documents

To apply, please upload the following applicant documents. Ensure your materials fully address the required and preferred job qualifications of the position. Please note, applicants may redact information from their application materials that identifies their age, date of birth, or dates of attendance at or graduation from an educational institution.

Resume/CV Employee Benefits

Colorado State University is not just a workplace; it's a thriving community that's transforming lives and improving the human condition through world-class teaching, research, and service. With a robust benefits package, collaborative atmosphere, and focus on work-life balance,CSUis where you can thrive, grow, and make a lasting impact.

  • Review our detailed benefits information here.

  • Explore the additional perks of working at CSU here.

  • For the total value of CSU benefits in addition to wages, use our compensation calculator.

  • Lastly, click here for more information about why Fort Collins is consistently ranked in the top cities to live in!

Background Check Policy Statement

Colorado State University strives to provide a safe study, work, and living environment for its faculty, staff, volunteers and students. To support this environment and comply with applicable laws and regulations,CSUconducts background checks for the finalist before a final offer. The type of background check conducted varies by position and can include, but is not limited to, criminal history, sex offender registry, motor vehicle history, financial history, and/or education verification. Background checks will also be conducted when required by law or contract and when, in the discretion of the University, it is reasonable and prudent to do so.

EEO

Colorado State University (CSU) provides equal employment opportunities to all applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

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About Colorado State University

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Colorado State University is one of the nation’s top public Tier 1 Research universities and an institution on the rise. Our Ram success is driven by an ambition to be excellent in all we do combined with an unparalleled location that is one of the fastest-growing and most vibrant areas in the country. CSU is a higher education destination for working and learning for faculty, staff, and students from across Colorado, the nation, and around the globe. CSU has produced record enrollment in the past decade, built on all-time highs in student diversity and student success, experienced record fundraising and research expenditures that keep hitting new highs year-after-year, and our faculty are known nationally and internationally for their groundbreaking research. Among other recognition for research and creative scholarship, CSU was recognized in 2022 as one of 10 top research institutions in the world contributing to solving the COVID pandemic. CSU is thriving, with a five-year average enrollment of more than 33,400 students. The record-setting 2022 incoming class of 5,517 students reflects 25% from diverse populations and 24% who were first in their families to attend college. CSU graduates find success with 85% securing a job related to their career plans within six months of graduation. More than nine out of 10 Rams would select CSU again, demonstrating the quality of the campus and learning environments.

Industry

Education

Company size

5,001 - 10,000 Employees

Headquarters location

Fort Collins, CO, US

Year founded

1870

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