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Senior Systems Engineer Jobs in Raleigh, NC (NOW HIRING)

Grantek Systems Integration

Systems Engineer

Raleigh, NC · On-site

... senior team members who are integral to our client's manufacturing processes. We are seeking a ... System programming, debugging, and testing. * Creating documentation, including project engineering ...

Grantek Systems Integration

Systems Engineer

Raleigh, NC · On-site +1

... senior team members who are integral to our client's manufacturing processes. We are seeking a ... System programming, debugging, and testing. * Creating documentation, including project engineering ...

ENTEK

Senior Control Systems Engineer

Wake Forest, NC · On-site

$85K - $145K/yr

Join ENTEK as a Senior Control Systems Engineer ENTEK is excited to welcome a Senior Control Systems Engineer to our growing team. If you're looking for a place where your expertise is valued, your ...

Amgen

Senior Manufacturing Systems Engineer

Holly Springs, NC · On-site

$90K - $123K/yr

Senior Manufacturing Systems Engineer What you will do Let's do this. Let's change the world. In this vital role you will be part of Amgen's most technologically advanced drug substance manufacturing ...

Relay

Senior Deployment Systems Engineer

Raleigh, NC · On-site

$101K - $139K/yr

Your Mission As a Senior Deployment Systems Engineer (Sr. DSE) , you are the principal technical architect and quarterback for Relay's largest, most strategic, and multi-faceted enterprise ...

Relay

Senior Deployment Systems Engineer

Raleigh, NC · Hybrid

$101K - $139K/yr

Your Mission As a Senior Deployment Systems Engineer (Sr. DSE) , you are the principal technical architect and quarterback for Relay's largest, most strategic, and multi-faceted enterprise ...

Ultra

Systems Engineer Senior I

Wake Forest, NC · On-site

$89K - $122K/yr

Leads small-to-medium sized systems Engineering projects or technical work packages within cost and quality requirements as assigned and may allocate or coordinate work with the project or work ...

Relay

Senior Deployment Systems Engineer

Raleigh, NC · On-site

$101K - $139K/yr

They are seeking a Senior Deployment Systems Engineer to lead and optimize complex enterprise deployments, ensuring technical vision and execution strategy are met for large-scale rollouts.

Berriehill Research

Senior AI Systems Engineer

Raleigh, NC · On-site +1

$92K - $126K/yr

... compatibility with existing systems and enterprise processes. * Design, implement, monitor, and optimize AI infrastructure, working with server, cloud, and platform engineering teams.

ARA

Senior AI Systems Engineer

Raleigh, NC · On-site

$92K - $126K/yr

... compatibility with existing systems and enterprise processes. * Design, implement, monitor, and optimize AI infrastructure, working with server, cloud, and platform engineering teams.

Grantek

Systems Engineer

Raleigh, NC · On-site +1

... senior team members who are integral to our client's manufacturing processes. We are seeking a ... System programming, debugging, and testing. * Creating documentation, including project engineering ...

Procom Consultants Group

Systems Engineer

Durham, NC

Systems Engineer Job Details Deliver engineering specifications, assist with functional specifications, and collaborate on technical designs and specifications for projects and initiatives. Estimate ...

Clever Devices Ltd.

Senior Embedded Systems Engineer

Apex, NC · On-site

$95K - $124K/yr

In this position, the Sr Embedded Systems Engineer will be working on our Radio and Wireless Technology products. Qualified candidates will possess: * BS in Engineering, Computer Science or a related ...

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All JobsSystems Engineer JobsSenior Systems Engineer JobsSenior Systems Engineer Jobs in Raleigh, NC

Senior Systems Engineer information

See Raleigh, NC salary details

$54.4K

$121.2K

$171.1K

How much do senior systems engineer jobs pay per year?

As of Jun 12, 2026, the average yearly pay for senior systems engineer in Raleigh, NC is $121,243.00, according to ZipRecruiter salary data. Most workers in this role earn between $101,600.00 and $139,000.00 per year, depending on experience, location, and employer.

What are Senior Systems Engineers?

Senior Systems Engineers are experienced professionals responsible for designing, implementing, and maintaining complex IT systems within an organization. They oversee the integration of hardware and software, ensure system reliability, and troubleshoot advanced technical issues. Senior Systems Engineers often lead projects, mentor junior staff, and collaborate with other departments to meet organizational goals. Their role is critical in maintaining the infrastructure that supports business operations.

What are some common challenges faced by Senior Systems Engineers when integrating new technologies into existing infrastructure?

Senior Systems Engineers often encounter challenges such as ensuring compatibility between legacy systems and new technologies, minimizing downtime during migrations, and addressing unforeseen security vulnerabilities. Effective integration requires thorough planning, cross-team collaboration, and detailed testing to avoid disruptions to business operations. Staying current with emerging technologies and adopting best practices for change management are essential for overcoming these challenges and ensuring smooth implementation.

What are the key skills and qualifications needed to thrive as a Senior Systems Engineer, and why are they important?

To thrive as a Senior Systems Engineer, you need expertise in systems architecture, troubleshooting, and network administration, typically supported by a degree in computer science or a related field and several years of relevant experience. Familiarity with virtualization platforms, cloud services (like AWS or Azure), automation tools (such as Ansible or PowerShell), and certifications like CompTIA, Microsoft, or Cisco are often required. Outstanding problem-solving, communication, and project management skills help you lead initiatives and collaborate effectively across teams. These competencies are crucial for ensuring system reliability, scalability, and security in complex IT environments.

What Is a Senior Systems Engineer?

A senior systems engineer is an IT (information technology) professional tasked with designing and maintaining network systems and security. Examples include large server or storage systems, computer networks, and mainframes. As a systems engineer, your primary duties are to oversee the daily operations of your facility and lead a team of engineers in designing new systems to replace old ones. You may work for a company that provides engineering services and solutions for other businesses, or you may be part of a large university or other institution's IT department. Skills needed for the career include the ability to work independently, leadership, and analytical problem-solving. A bachelor’s degree in electrical engineering or IT and significant experience in a lower systems engineering position are essential qualifications.

What is the difference between Senior Systems Engineer vs Systems Administrator?

AspectSenior Systems EngineerSystems Administrator
CertificationsCompTIA Security+, Cisco CCNA, Microsoft certificationsCompTIA A+, Network+, Microsoft certifications
Work EnvironmentDesigning, implementing, and troubleshooting complex systemsManaging daily system operations and user support
Industry UsageIT, technology, enterprise environmentsIT support, small to medium businesses

While both roles involve working with IT systems, Senior Systems Engineers focus on designing and implementing complex infrastructure, whereas Systems Administrators handle routine maintenance and user support. The senior role typically requires more advanced certifications and experience, and often involves strategic planning and system architecture.

More about Senior Systems Engineer jobs
What are the most commonly searched types of Systems Engineer jobs in Raleigh, NC? The most popular types of Systems Engineer jobs in Raleigh, NC are:
What are popular job titles related to Senior Systems Engineer jobs in Raleigh, NC? For Senior Systems Engineer jobs in Raleigh, NC, the most frequently searched job titles are:
What job categories do people searching Senior Systems Engineer jobs in Raleigh, NC look for? The top searched job categories for Senior Systems Engineer jobs in Raleigh, NC are:
What cities near Raleigh, NC are hiring for Senior Systems Engineer jobs? Cities near Raleigh, NC with the most Senior Systems Engineer job openings:
Senior Systems Engineer jobs near you
Infographic showing various Senior Systems Engineer job openings in Raleigh, NC as of June 2026, with employment types broken down into 3% As Needed, 93% Full Time, 1% Part Time, 1% Temporary, 1% Contract, and 1% Nights. Highlights an 87% Physical, 5% Hybrid, and 8% Remote job distribution, with an average salary of $121,243 per year, or $58.3 per hour.

Senior Manufacturing Systems Engineer

Amgen, Inc.

Holly Springs, NC • On-site

$90K - $123K/yr

Full-time

Medical, Dental, Vision, Life, Retirement

Posted 6 days ago

Job description

Career Category
Information Systems
Job Description
Join Amgen's Mission of Serving Patients
At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission-to serve patients living with serious illnesses-drives all that we do.
Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.
Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Senior Manufacturing Systems Engineer
What you will do
Let's do this. Let's change the world. In this vital role you will be part of Amgen's most technologically advanced drug substance manufacturing plant. The facility continues to expand in size and advance with embedded new technologies and industry 4.0 capabilities facility wide.
As a Senior Manufacturing Systems Engineer, you will:
  • Work with process subject matter experts (SMEs) to understand key process requirements and transform them into digital automated solutions.
  • Collaborate with business partners to understand how automation can improve workflow and productivity. Synthesize requirements from clients, customers or end-users to develop the best automation solutions.
  • Lead and support functional area projects focused on improving process equipment/utilities/facilities as well as large/sophisticated capital projects to integrate new drug substance manufacturing technologies into the facility
  • Lead and support new product introductions (NPI) or new technology introductions by performing automation engineering assessments, implementing automation system configuration changes and supporting engineering and process qualification runs as applicable.
  • Build the business processes to support the project scope in alignment with project timelines. Develop detailed specification and engineering policies and procedures that affect multiple organizational units.
  • Provide clear documentation for delivered solutions and processes; work closely with QA partners while supporting computerized systems validation processes in a GxP environment.
  • Ability to anticipate, evaluate and resolve project issues, delays, and problems by using technical, project management, and business expertise. Manage multiple initiatives and priorities.
  • Be constantly curious and feed your passion and interests in groundbreaking technology. Use your given time to look for new and innovative ways to do business differently, better, and more cost effectively

What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The professional we seek will have these qualifications.
Basic Qualifications:
  • Doctorate degree OR
  • Master's degree and 2 years of Manufacturing Process automation/Information system experience OR
  • Bachelor's degree and 4 years Manufacturing Process automation/Information system experience OR
  • Associate's degree and 8 years of Manufacturing Process automation/Information system experience OR
  • High school diploma / GED and 10 years of Manufacturing Process automation/Information system experience

Preferred Qualifications:
  • Demonstrable experience in a manufacturing environment with ability in the Pharmaceutical or Biotechnology industries.
  • Direct knowledge of Automation design, experience in process control engineering and troubleshooting with GMP biopharmaceutical production facility equipment/systems such as media, harvest, bioreactors, chromatography, vial filtration, and ultrafiltration/diafiltration, and integrating various OEM automation software packages.
  • Extensive understanding and background in programming, design, installation and lifecycle management of manufacturing process controls, automation and field instrumentation technologies.
  • Experience with Emerson Delta-V DCS system, Process Control Network design including network segregation, and Process Control System Virtual Infrastructure design and implementation.
  • Demonstrable understanding of GAMP software development lifecycle, ANSI/ISA-S88 and S95 industry standards and methodologies to establish a PCS and MES implementation and Systems Integration that meets Operations' business requirements.
  • Experience in Capital Project Lifecycle Management: Conceptual Design, Scope and cost estimate development, business case development, detailed design, engineering and validation documentation and project execution.
  • Demonstrated hands-on experience in developing process control strategies for New Product Introduction and New Technology Deployment for Drug Substance Plant Operations.
  • Position requires an in-depth knowledge and hands-on coding experience of Emerson Delta V Platform in particular, and on Rockwell FactoryTalk, Rockwell PLC's. Aveva PI Data Historian knowledge is preferred.
  • Kneat platform-based C&Q documentation development knowledge a plus
  • The ideal individual must be a self-directed team player ready to mentor and develop engineering staff and embrace a team-based culture that relies on collaboration for effective decision-making.
  • Strong leadership, technical writing, and communication/presentation skills.

What you can expect from us
As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.
In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:
  • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models, including remote and hybrid work arrangements, where possible

Apply now for a career that defies imagination
Objects in your future are closer than they appear. Join us.
careers.amgen.com
In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.
As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
#CLOLI
Salary Range
135,728.00 USD - 159,431.00 USD

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