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Senior Python Software Engineer Jobs in Raleigh, NC

Pearson

Senior Software Engineer

Raleigh, NC · Remote

$150K - $180K/yr

PRODUCT ENGINEERING - REMOTE Senior Software Engineer / Architect We're looking for a Senior Software Engineer / Architect to join our engineering organization as a senior individual contributor.

Seneca

Senior Software Engineer

Raleigh, NC · On-site

$65/hr

Senior Software Engineer Location: Raleigh, NC Clearance Requirements: None Pay Rate: $65.00/hr Position Description: Join our client's Business Integrations team as a Senior Software Engineer. You ...

IXL Learning

Senior Software Engineer

Raleigh, NC · On-site

$119K - $157K/yr

They are seeking a Senior Software Engineer to help enhance existing educational products and build new innovative solutions, working collaboratively with a talented team of engineers.

ENFOS, Inc.

Senior Software Engineer - 2026

Durham, NC

$118K - $156K/yr

As a Senior Software Engineer at ENFOS, you will report to the Head of Engineering and play a key ... Java, Python, or similar * Strong experience with modern development practices, including CI/CD ...

Red Hat

Senior Software Engineer - Openstack

Raleigh, NC · On-site +1

$118K - $195K/yr

The Red Hat Openstack Engineering team is looking for a Senior Software Engineer to join us in ... Proficiency in Python (OpenStack's primary language), Go, and C/C++. * Domain Knowledge: Solid ...

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All JobsSenior Python Software Engineer JobsSenior Python Software Engineer Jobs in Raleigh, NC

Senior Python Software Engineer information

See Raleigh, NC salary details

$53.5K

$138K

$189.6K

How much do senior python software engineer jobs pay per year?

As of Jun 22, 2026, the average yearly pay for senior python software engineer in Raleigh, NC is $138,012.00, according to ZipRecruiter salary data. Most workers in this role earn between $118,100.00 and $158,900.00 per year, depending on experience, location, and employer.

What is the difference between Senior Python Software Engineer vs Python Developer?

AspectSenior Python Software EngineerPython Developer
Required CredentialsBachelor's degree in CS or related field, experience in software engineeringBachelor's degree in CS or related field, coding proficiency
Work EnvironmentDesigning complex systems, leading projects, mentoringWriting code, developing applications, debugging
Employer & Industry UsageTech companies, startups, enterprise softwareWeb development, data analysis, automation projects
Common Search & Comparison IntentUnderstanding senior-level roles, responsibilities, and skillsEntry to mid-level coding roles, project involvement

The main difference between a Senior Python Software Engineer and a Python Developer lies in experience, responsibilities, and scope. Senior engineers typically lead projects, design system architecture, and mentor junior staff, while Python Developers focus on coding, application development, and implementation. Both roles require strong Python skills and relevant credentials, but senior roles demand more experience and leadership capabilities.

What are some common challenges faced by Senior Python Software Engineers when leading complex projects, and how can they be addressed?

Senior Python Software Engineers often face challenges such as balancing hands-on coding with mentoring junior team members, managing technical debt, and designing scalable solutions. Successfully addressing these challenges involves clear communication, proactive code reviews, and effective prioritization of tasks. Collaborating closely with cross-functional teams and fostering a culture of knowledge sharing can also help ensure project success and team growth.

What is the salary of senior Python developer?

The salary of a senior Python software engineer typically ranges from $100,000 to $150,000 annually, depending on experience, location, and industry. Skilled professionals with expertise in frameworks like Django or Flask and experience with cloud services may earn higher compensation.

Will AI replace Python coders?

AI tools can automate certain coding tasks, but Senior Python Software Engineers are essential for designing, developing, and maintaining complex software systems. AI is more likely to augment coding work rather than fully replace experienced developers, who bring problem-solving, creativity, and domain expertise that AI cannot replicate fully.

What are the key skills and qualifications needed to thrive as a Senior Python Software Engineer, and why are they important?

To thrive as a Senior Python Software Engineer, you need advanced proficiency in Python programming, strong problem-solving abilities, and a solid background in computer science or a related field. Familiarity with frameworks like Django or Flask, experience with version control systems such as Git, and knowledge of cloud platforms and CI/CD tools are typically required. Leadership, effective communication, and mentorship skills help you collaborate with teams and guide junior developers. These skills ensure the delivery of robust, scalable software solutions and foster a productive, innovative development environment.

What engineers make $500,000?

Senior Python Software Engineers with extensive experience, specialized skills in areas like machine learning or data engineering, and working in high-paying industries such as finance or tech can earn $500,000 or more annually. Compensation often includes base salary, bonuses, and stock options, especially at large tech companies or startups with significant funding.

What does a Senior Python Software Engineer do?

A Senior Python Software Engineer designs, develops, tests, and maintains complex software applications using the Python programming language. They often lead or mentor junior developers, architect software solutions, and ensure best coding practices are followed. These professionals collaborate with cross-functional teams to deliver scalable and efficient systems, troubleshoot issues, and optimize application performance. Their expertise includes advanced knowledge of Python frameworks, libraries, and development tools, as well as experience with databases, APIs, and cloud services.

Is it possible to make 300k as a software engineer?

Senior Python software engineers with extensive experience, specialized skills, and working in high-paying industries or companies can reach or exceed a $300,000 annual salary, especially with bonuses and stock options. Achieving this level often requires advanced knowledge of frameworks, cloud platforms, and a strong track record of project success.
What are popular job titles related to Senior Python Software Engineer jobs in Raleigh, NC? For Senior Python Software Engineer jobs in Raleigh, NC, the most frequently searched job titles are:
What job categories do people searching Senior Python Software Engineer jobs in Raleigh, NC look for? The top searched job categories for Senior Python Software Engineer jobs in Raleigh, NC are:
What cities near Raleigh, NC are hiring for Senior Python Software Engineer jobs? Cities near Raleigh, NC with the most Senior Python Software Engineer job openings:
Senior Python Software Engineer jobs near you
Software Engineer

Software Engineer

Collaborations Pharmaceuticals Inc

Raleigh, NC • On-site

Other

Medical, Retirement, PTO

This job post has expired today. Applications are no longer accepted.

Job description

Software Engineer

Collaborations Pharmaceuticals, Inc. is a fast-growing organization searching for go-getters who welcome the challenges of a growing business. We're specifically looking for a Software Engineer for a full-time position who will roll up their sleeves and drive best in class development of our Assay Central, MegaTox, MegaTrans, and MegaSyn software programs.

We are looking for an experienced software engineer (5-10 years or more) with at least BS or MS degree. Excellent oral and written communication skills in English are required. Customer-facing skills are vital. The position will be expected to lead a small team of developers and chemists. This position located on site in Raleigh on the Centennial Campus, in person in the office.

Applicants with experience in the following will be preferred: JavaScript, VUE.js, Python, Airflow, AWS, databases (postgreSQL), Pytorch, Tensorflow, Scikit learn. Knowledge of chemistry is a plus.

Collaborations Pharmaceuticals is a competitive employer with a broad range of benefits, including paid vacation and sick leave, 401K with match, and subsidized healthcare plan.

Please submit cover letter, CV, and contact information for 2-3 references to Sean Ekins, Ph.D., D.Sc., CEO by e-mail to: sean@collaborationspharma.com.

Position opens immediately.

Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3150, Raleigh, NC 27606

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