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Senior Python Developer Jobs in Durham, NC (NOW HIRING)

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Senior Structural Engineer

Raleigh, NC · On-site

$85 - $115/hr

About the Role As a Senior Structural Engineer, you'll lead the structural effort across projects ... VBA and Python for design automation) to deliver and document designs. * Mentor engineers and ...

Socket.dev

Senior Software Engineer - RTP

Raleigh, NC · On-site

$120 - $160/hr

VAST Data is looking to add a Senior Developer to our growing team! This is a unique opportunity to ... developer with strong skills in C, C++, or Python to join our V-Force team--a specialized ...

First Citizens Bank

Senior Software Engineer

Raleigh, NC · On-site

$119K - $157K/yr

Strong understanding of API development, cloud architecture, and DevOps practices * Strong ... Advanced proficiency in Python and SQL. * Advanced experience developing and supporting ETL/ELT ...

First Citizens Bank

Senior Software Engineer

Raleigh, NC · On-site

$119K - $157K/yr

Strong understanding of API development, cloud architecture, and DevOps practices * Strong ... Advanced proficiency in Python and SQL. * Advanced experience developing and supporting ETL/ELT ...

First Citizens Bank

Senior Software Engineer

Raleigh, NC · On-site

$119K - $157K/yr

Strong understanding of API development, cloud architecture, and DevOps practices * Strong ... Advanced proficiency in Python and SQL. * Advanced experience developing and supporting ETL/ELT ...

Microsoft

Senior CAD Software Engineer

Raleigh, NC · On-site

$119/hr

Experienced writing software with industry standard languages like Python, TCL, Perl, C/C++ (Python ... Expertise in Azure environments, Azure Security and DevOps concepts * Exposure to Design and ...

TEKsystems

Sr AI/ML Engineer

Durham, NC · Hybrid

$180K - $220K/yr

... strong Python. Description The Senior AI/ML Engineer helps move AI from consultant-led pilots to a sustainable internal capability by combining ML engineering, GenAI integration, and prompt ...

TEKsystems

Sr AI/ML Engineer

Durham, NC · Hybrid

$180K - $220K/yr

... strong Python. Description The Senior AI/ML Engineer helps move AI from consultant-led pilots to a sustainable internal capability by combining ML engineering, GenAI integration, and prompt ...

Compunnel

Senior Data Scientist

Raleigh, NC · On-site

JOB SUMMARY As a Senior Data Scientist 5, you will join a team of other talented Data Scientists ... Python or another programming language Be experienced in mentoring, training, and acting as a ...

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All JobsPython Developer JobsSenior Python Developer JobsSenior Python Developer Jobs in Durham, NC

Senior Python Developer information

See Durham, NC salary details

$49.8K

$128.6K

$176.7K

How much do senior python developer jobs pay per year?

As of Aug 12, 2026, the average yearly pay for senior python developer in Durham, NC is $128,639.00, according to ZipRecruiter salary data. Most workers in this role earn between $110,100.00 and $148,100.00 per year, depending on experience, location, and employer.

What are the main responsibilities of a senior Python developer?

A Senior Python Developer is responsible for designing, developing, and maintaining complex software applications using the Python programming language. They lead the technical aspects of projects, mentor junior developers, and ensure code quality through code reviews and best practices. Additionally, they collaborate with cross-functional teams to gather requirements, solve technical challenges, and deploy scalable and efficient solutions. Senior Python Developers are also expected to stay updated with the latest trends and advancements in Python and related technologies.

What is the difference between Senior Python Developer vs Python Developer?

AspectSenior Python DeveloperPython Developer
Required ExperienceTypically 5+ years, with leadership and complex project experienceUsually 1-3 years, focusing on core Python skills
ResponsibilitiesDesigning architecture, mentoring, handling complex systemsWriting code, debugging, implementing features
CertificationsOptional but beneficial (e.g., Python certifications, cloud certs)Often not required
Work EnvironmentCollaborative teams, project planning, code reviewsDevelopment-focused, task-oriented

The main difference between a Senior Python Developer and a Python Developer lies in experience, responsibilities, and leadership. Senior developers handle complex projects, mentor others, and often participate in architecture decisions, while Python Developers focus on coding and feature implementation. Both roles are essential in tech companies, but the senior role requires more experience and broader skills.

How much does a senior Python developer make?

A senior Python developer's salary typically ranges from $100,000 to $150,000 annually, depending on experience, location, and industry. They often possess strong skills in frameworks like Django or Flask and may have certifications or experience with cloud platforms, which can influence compensation.

What are the key skills and qualifications needed to thrive as a senior Python developer?

To thrive as a Senior Python Developer, you need advanced proficiency in Python programming, experience with software architecture, and a solid understanding of algorithms and data structures, usually backed by a degree in computer science or related fields. Familiarity with frameworks like Django or Flask, version control systems such as Git, and containerization tools like Docker are typically required, alongside knowledge of modern CI/CD pipelines. Strong problem-solving abilities, effective communication, and leadership skills help you collaborate with teams and mentor junior developers. Mastery of these skills ensures the delivery of scalable, maintainable software solutions and the ability to drive technical excellence within development teams.

What are some common challenges faced by senior Python developers when leading a development team?

Senior Python Developers often encounter challenges such as balancing hands-on coding with mentoring junior team members and ensuring code quality across the team. They are also responsible for making architectural decisions, which requires staying updated on best practices and emerging Python frameworks. Additionally, coordinating collaboration between cross-functional teams (like DevOps, QA, and front-end developers) can be complex, especially in agile environments where requirements may shift rapidly. Overcoming these challenges helps foster a productive and innovative team culture.
What are the most commonly searched types of Python Developer jobs in Durham, NC? The most popular types of Python Developer jobs in Durham, NC are:
What are popular job titles related to Senior Python Developer jobs in Durham, NC? For Senior Python Developer jobs in Durham, NC, the most frequently searched job titles are:
What job categories do people searching Senior Python Developer jobs in Durham, NC look for? The top searched job categories for Senior Python Developer jobs in Durham, NC are:
What cities near Durham, NC are hiring for Senior Python Developer jobs? Cities near Durham, NC with the most Senior Python Developer job openings:
Senior Python Developer jobs near you
Infographic showing various Senior Python Developer job openings in Durham, NC as of August 2026, with employment types broken down into 2% Internship, 84% Full Time, 8% Part Time, and 6% Contract. Highlights an 79% Physical, 6% Hybrid, and 15% Remote job distribution, with an average salary of $128,639 per year, or $61.8 per hour.

Sr Machine Learning Engineer[Remote]

SmartIPlace

Raleigh, NC • On-site

$80/hr

Contractor

Re-posted 12 days ago

Job description

Title: Sr Machine Learning Engineer       

Duration: 6-12 Mos C2H (no sponsorship at conversion or future)           

Location: REMOTE EST (Raleigh hybrid preferred); EST/CST only, no MST/PST     

Rate: $80 /hr. on W2

Visa: USC, GC

Note:

Relocation to Raleigh hybrid considered above remote; Sr MLE to lead AI/ML and agentic systems architecture     

Top Requirement:

10+ yrs production ML at scale; LLM/GenAI/RAG deployment; Cloud (AWS/Azure/GCP); Kubernetes/containerization; Agentic systems & tool orchestration; MCP servers; Strong Python            

 

Preferred:

MLOps/CI/CD; Responsible AI; Multi-step reasoning agents; Low-latency inference platforms; Mentoring exp

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About Smart-iPlace

Sourced by ZipRecruiter

SMART-iPLACE provides innovative staffing and consulting solutions that help our clients achieve their business objectives. We can understand and support all areas of your IT systems from back-end infrastructure to front-end personal productivity. Our goal is create innovative IT solutions that enable your business to be more agile and competitive.

Industry

It services

Company size

51 - 200 Employees

Headquarters location

Irving, TX, US

Year founded

2021

Social media

Facebook

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