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Senior Principal Scientist Jobs (NOW HIRING)

Boehringer Ingelheim GmbH

$140 - $269/hr

Senior Principal/ Principal Scientist, Computational Safety Description We are seeking a Senior Principal/ Principal Scientist, Computational Safety, to provide scientific leadership in in silico ...

Frontage Laboratories

Principal Scientist

Exton, PA · On-site

In vitro ADME Senior/Principal Scientist - DMPK Location: Exton, PA Department: DMPK (Drug Metabolism & Pharmacokinetics) Employment Type: Full-Time Company Frontage Laboratories Inc. is an award ...

Zap Energy

Senior/Principal Scientist (Theory)

Everett, WA · On-site

$130K - $160K/yr

About the opportunity As a Senior/Principal Scientist (Theory), you'll play a critical role in advancing our understanding of Z-pinch operation. As part of the Theory & Modeling team, you'll deploy ...

Colgate

NJ · On-site

$124 - $180/hr

Senior Principal Scientist - Spectroscopy (Hybrid). Location: Piscataway, New Jersey. Travel: up to 10% of time. Responsibilities * Design and validate analytical protocols for active and critical ...

Amgen

Senior Principal Scientist

Thousand Oaks, CA · On-site +1

Senior Principal Scientist What you will do Let's do this. Let's change the world! We are seeking an experienced toxicologist in the Product Stewardship group within our Environment, Health, Safety ...

Colgate

NJ · On-site

$124 - $174/hr

Sr Principal / Principal Scientist Personal Care Formulation & Implementation Job Alerts Link Established in 1806 as a small soap and candle business in New York City, Colgate-Palmolive is now a ...

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Senior Principal Scientist information

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$68.5K

$144K

$190.5K

How much do senior principal scientist jobs pay per year?

As of Sep 3, 2026, the average yearly pay for senior principal scientist in the United States is $144,009.00, according to ZipRecruiter salary data. Most workers in this role earn between $117,500.00 and $169,000.00 per year, depending on experience, location, and employer.

What is a senior principal scientist?

A Senior Principal Scientist is an advanced-level research professional who leads complex scientific projects and provides strategic direction within their field of expertise. They typically oversee teams of scientists, develop research programs, and contribute to the advancement of scientific knowledge or product innovation. This role often requires extensive experience, a doctoral degree, and a proven track record of impactful research. Senior Principal Scientists also mentor junior staff and collaborate with cross-functional teams to achieve organizational goals.

What does a senior principal scientist do?

As a Senior Principal Scientist, you will often serve as a scientific leader and subject matter expert on cross-functional project teams, working closely with colleagues in research, development, regulatory, and commercial departments. Your responsibilities may include designing experiments, interpreting complex data, and providing strategic input to guide project direction. Effective collaboration and communication are key, as you will mentor junior scientists, align research goals with business objectives, and ensure scientific rigor across projects. This role often involves presenting findings to both technical and non-technical stakeholders, requiring the ability to translate complex science into actionable recommendations.

What skills and qualifications are needed to be a senior principal scientist?

To thrive as a Senior Principal Scientist, you need an advanced degree (PhD) in a relevant scientific field, extensive research experience, and a strong track record of publications and project leadership. Familiarity with specialized laboratory equipment, data analysis software, and regulatory compliance systems is typically required. Exceptional problem-solving, mentorship, and collaboration skills help distinguish top performers in this position. These qualifications are crucial for driving scientific innovation, ensuring research quality, and leading multidisciplinary teams to achieve impactful results.

What is the difference between Senior Principal Scientist vs Principal Scientist?

AspectSenior Principal ScientistPrincipal Scientist
Required CredentialsAdvanced degrees (PhD), extensive research experience, industry certificationsMaster's or PhD, significant research background
Work EnvironmentLeading complex projects, mentoring teams, strategic planningConducting research, developing new methods, supporting project teams
Employer & Industry UsageResearch institutions, biotech, pharma, tech companiesResearch labs, R&D departments in similar industries

Senior Principal Scientists typically hold more advanced credentials and lead strategic initiatives, mentoring teams and overseeing large projects. Principal Scientists focus on conducting research and developing innovations, often supporting senior staff. Both roles are vital in R&D, but the Senior Principal Scientist has a broader leadership and strategic scope.

What is the average salary for a Senior Principal Scientist?

The average salary for a Senior Principal Scientist in the US typically ranges from $130,000 to $180,000 annually, depending on industry, location, and experience. Senior Principal Scientists often hold advanced degrees and have extensive expertise in their field, which can influence compensation levels.
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Senior Principal Scientist jobs near you
Infographic showing various Senior Principal Scientist job openings in the United States as of August 2026, with employment types broken down into 90% Full Time, 8% Part Time, 1% Temporary, and 1% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $144,009 per year, or $69.2 per hour.

Senior Principal/ Principal Scientist, Computational Safety

Boehringer Ingelheim GmbH

On-site

$140 - $269/hr

Other

Posted 19 days ago

Job description

Senior Principal/ Principal Scientist, Computational Safety Description

We are seeking a Senior Principal/ Principal Scientist, Computational Safety, to provide scientific leadership in in silico safety assessment across drug discovery and development. This role will leverage advanced multi omics data, systems toxicology and AI/ML approaches to proactively identify safety liabilities, support mechanistic understanding, improve quality target identification, and facilitate risk based decision making.

The Senior Principal Scientist/ Principal will play a key role in developing and delivering integrated computational safety strategies, including AI enabled foundation model based on multiple omics data, Adverse Outcome Pathways, off-target identification, and predictive liability models. Working closely with toxicologists, discovery scientists, clinical safety, bioinformatics, data science, and IT partners, this position will translate complex computational insights into clear, actionable recommendations that improve pipeline quality and reduce late stage attrition.

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunities for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

Duties & Responsibilities
  • Lead and/or generate in silico target safety assessment strategy development
  • Develop and deliver integrated computational safety packages to support program and portfolio decisions
  • Advance AI/ML and multi-omics-based models, including foundation models, for safety and liability prediction
  • Drive AI enabled Adverse Outcome Pathway (AoP) development to support mechanistic risk assessment
  • Proactively identify and communicate on target and off target safety risks
  • Collaborate closely with Toxicology, Discovery, Clinical Safety, Bioinformatics, Data Science, and IT teams
  • Serve as a bridge and clearly communicate complex computational insights to multidisciplinary stakeholders.
Requirements
  • Ph.D. in Computational Toxicology, Computational Biology, Bioinformatics, Molecular Biology, or related field with minimum 7+ years of post-doctoral and/or industry experience in drug discovery and development and ≥3 years of experience in safety risk assessment is a must
  • Strong collaboration, scientific leadership, and communication skills, with the ability to translate complex computational results into actionable insights for stakeholders with diverse backgrounds
  • Expertise in computational toxicology, AI/ML modeling, and multi-omics (TGx) data integration
  • Experience with in silico safety, liability prediction, and mechanistic modeling
  • Familiar with toxicology related data curation, and interpretation, and knowledge of GLP toxicology and regulatory guidance will be a favorable plus
Eligibility Requirements
  • Must be legally authorized to work in the United States without restriction.
  • Must be willing to take a drug test and post-offer physical (if required)
  • Must be 18 years of age or older
Compensation Data

The base salary range for the Scientist II position is $140,000 to $222,000.

The base salary range for the Scienitst III position is $170,0000 to $269,000.

The position may be eligible for a role specific discretionary bonus, relocation, and/or other compensation elements. We continuously review market data and may adjust salary ranges as needed in the future. Actual compensation will be based on job-related factors such as skills, experience, and qualifications, and other factors permitted by law. For an overview of our benefits pleaseclick here .

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