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Senior Backend Developer Python Jobs (NOW HIRING)

Senior Back-End Developer

Manhattan, NY · On-site

$132K - $172K/yr

As a Senior Back-End Developer, you will be instrumental in designing, developing, and maintaining the back end of complex microservices architecture, ensuring scalability and performance for the ...

Senior Backend Engineer

Boston, MA · Remote

$160K - $240K/yr

Senior Backend Engineer Role The Opportunity As a Senior Backend Engineer, you'll design and build ... Strong Python skills and experience with large-scale systems * Solid understanding of APIs ...

Senior Backend Developer

Toronto, KS · On-site

$72.85 - $101.99/hr

The Opportunity ShyftLabs is looking for a Senior Developer to help design, build, and scale our ... Drive development across teams for services built in Node.js, TypeScript, JavaScript, and Python

New

Senior Backend Engineer

Arlington, TX · On-site

$90 - $120/hr

Fostering collaboration across teams (front-end, DevOps, QA) for seamless product delivery ... Expertise in a high-level programming language (Python, Java, .NET, etc.). * Familiarity with ...

New

J0726-1876 Employment Type: Full Time Position Description: We're growing rapidly and are looking for a Senior Backend Developer with Python Application Developer experience. At CGI, you'll make an ...

Senior Back-End Developer

Miami, FL · On-site

$159K - $176K/yr

Rumble is seeking a Senior Back-End Developer to design, build, and maintain high-performance server-side systems that power a large-scale video platform serving millions of users. This is a senior ...

Sr. Backend AI Engineer Location:  Cleveland, OH Role Overview Move beyond traditional ETL. At ... Python-based backend systems that utilize LLMs and AI agents to automate the discovery, parsing ...

Sr. Backend AI Engineer Location: Cleveland, OH Role Overview Move beyond traditional ETL. At ... Build Python-based backend systems that utilize LLMs and AI agents to automate the discovery ...

$120 - $140/hr

We are seeking a Senior Backend Engineer to design, build, and scale critical rental systems that power core business operations. This role requires strong expertise on backend development, with the ...

New

Sr. Backend Developer

Estero, FL · On-site

$120 - $140/hr

We are seeking a Senior Backend Engineer to design, build, and scale critical rental systems that power core business operations. This role requires strong expertise on backend development, with the ...

Backend Engineer Senior Location: Orlando, FL Duration: Permanent Position Description: Kforce is ... Advanced proficiency in Node.js and Python * Strong grasp of API design patterns (REST, GraphQL ...

Python Backend Developer Hybrid for NYC Long term Contract Job Summary We are looking for an experienced Python Backend Developer to design, develop, and maintain scalable backend applications and ...

Showing results 41-60

Senior Backend Developer Python information

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$16K

$148.2K

$191K

How much do senior backend developer python jobs pay per year?

As of Aug 20, 2026, the average yearly pay for senior backend developer python in the United States is $148,233.00, according to ZipRecruiter salary data. Most workers in this role earn between $145,500.00 and $167,500.00 per year, depending on experience, location, and employer.

What does a senior backend developer Python do?

A Senior Backend Developer Python designs, builds, and maintains the server-side logic and databases for web applications, primarily using the Python programming language. They are responsible for ensuring high performance, responsiveness, and security of applications, integrating with front-end elements, and working closely with other developers and stakeholders. Additionally, they often mentor junior developers, review code, and contribute to architectural decisions to ensure scalable and robust backend systems.

What are the key skills and qualifications needed to thrive as a senior backend developer Python?

To thrive as a Senior Backend Developer Python, you need deep expertise in Python programming, software architecture, and experience with databases and API development, usually supported by a computer science degree and several years of professional coding experience. Familiarity with frameworks like Django or Flask, cloud platforms (e.g., AWS, Azure), and version control systems such as Git is typically expected, along with knowledge of containerization tools like Docker. Strong problem-solving skills, collaboration, and clear communication set top performers apart in this role. These skills ensure the development of robust, scalable backend systems that meet business needs and support seamless integration with other technologies.

What are some common challenges faced by senior backend developers working with Python, and how can they be addressed?

Senior Backend Developers working with Python often encounter challenges such as ensuring high performance and scalability of applications, especially when dealing with large volumes of data or high user traffic. Managing dependencies and maintaining clean, modular codebases can also be demanding in complex projects. These challenges are typically addressed by leveraging advanced Python frameworks, implementing robust testing practices, and collaborating closely with DevOps and frontend teams to optimize system architecture and deployment pipelines. Continuous learning and staying updated with best practices in Python and backend development are also key to overcoming these obstacles.

What is the difference between Senior Backend Developer Python vs Backend Developer Python?

AspectSenior Backend Developer PythonBackend Developer Python
Required Experience5+ years, leadership skills1-3 years, foundational skills
CertificationsRelevant certifications (e.g., AWS, Python)Optional, entry-level certifications
Work EnvironmentDesigning architecture, mentoringImplementing features, coding
ResponsibilitiesSystem design, team coordinationCode development, bug fixing

The main difference between a Senior Backend Developer Python and a Backend Developer Python lies in experience, responsibilities, and leadership. Senior developers typically lead projects and mentor others, while backend developers focus on coding and feature implementation. Both roles require strong Python skills and relevant certifications, but senior roles demand more experience and strategic involvement.

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The most popular types of Backend Developer Python jobs are:

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States with the most job openings for Senior Backend Developer Python jobs include:

Infographic showing various Senior Backend Developer Python job openings in the United States as of August 2026, with employment types broken down into 1% Internship, 87% Full Time, 6% Part Time, and 6% Contract. Highlights an 76% Physical, 7% Hybrid, and 17% Remote job distribution, with an average salary of $148,233 per year, or $71.3 per hour.

$90 - $150/hr

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Job description

Imaging Endpoints (IE) is an Imaging Technology and Imaging Clinical Research Organization (iCRO). We are passionately focused on our vision to Connect Imaging to the CureTM. Everything we do is aligned with this singular purpose. We work every day excited to advance imaging science, technology, and services to bring curative technologies to humankind. We have supported many of the most impactful new drug approvals in oncology, and we are seeking the most talented individuals globally that are passionate in their desire to assist us in our mission to customize each clinical trial’s imaging to optimize the opportunity to demonstrate efficacy.

Imaging Endpoints is based in Scottsdale, Arizona, with offices in Cambridge, Massachusetts; London, UK; Leiden, Netherlands; Basel, Switzerland; Hyderabad, India and Shanghai, China. We are an affiliate of HonorHealth, one of the largest healthcare systems nationally, and Scottsdale Medical Imaging Limited (SMIL/RadPartners), the largest private radiology group in the United States. We are recognized as the world’s largest and most preeminent iCRO in oncology.

This position supports the development and maintenance of a web-based reporting platform by building Python backend services and APIs, integrating data from multiple SQL sources, and using AWS services to enable secure, reliable report generation and access.

BACKEND REPORTING DEVELOPER (PYTHON/REACT) RESPONSIBILITIES
  • Design, build, and maintain backend services in Python to power a web-based reporting tool.
  • Integrate with SQL databases to collect, validate, and transform data for reporting.
  • Develop reporting pipelines that generate, schedule, and distribute reports from collected data.
  • Implement and maintain RESTful APIs that service front-end requests for viewing and interacting with reporting data.
  • Build and optimize data models and SQL queries; store report metadata and results in a SQL database for retrieval and auditability.
  • Use AWS services to deploy, run, and operate the reporting backend.
  • Collaborate with React developers and product stakeholders to define API contracts, performance expectations, and user-facing reporting requirements.
  • Write automated tests, participate in code reviews, and maintain documentation for services, APIs, and data pipelines.
  • Implement security best practices for data access and API endpoints and support compliance requirements as applicable.
  • Monitor and troubleshoot production services; tune performance and reliability for reporting workloads.
  • Support CI/CD practices for repeatable builds and deployments.
  • Partner with data owners to understand source systems and ensure data quality, lineage, and appropriate use.
  • Other duties as assigned.
EDUCATION AND EXPERIENCE
  • Bachelor’s degree in Computer Science, Software Engineering, or related field (or equivalent practical experience).
  • 3+ years of professional experience building backend services with Python.
  • Experience integrating with SQL databases and writing efficient queries; familiarity with schema design and migrations.
  • Hands-on experience with AWS for application deployment and operations.
  • Experience collaborating with front-end teams; working knowledge of React and modern web development practices is preferred.
SKILLS
  • Strong Python fundamentals; experience building APIs, background jobs, and data pipelines
  • Proficiency with SQL and relational data modeling; ability to troubleshoot query and performance issues
  • Experience with AWS operational best practices.
  • Understanding of HTTP, web security fundamentals, and API versioning/documentation.
  • Ability to design reporting solutions with reliability and scalability in mind; attention to data quality and correctness.
  • Comfort working with React/front-end partners; ability to translate UI needs into efficient backend endpoints.
  • Strong communication, collaboration, and documentation skills; comfortable working across teams.
  • High standards for code quality: testing, code review, maintainability, and operational readiness.
  • Ability to handle sensitive data appropriately and follow applicable security and privacy policies.
IMAGING ENDPOINTS’ TEAM CHARACTERISTICS
  • Passion to Connect Imaging to the CureTM and pursue a meaningful career by improving the lives of cancer patients through imaging.
  • Strong desire to be part of a dynamic, global team working closely together and growing year after year in a rewarding environment to help humanity through imaging.
  • Commitment and caring for our fellow team members, their families, and the communities IE serves – see more information about Caring Endpoints at https://caringendpoints.org/
  • Integrity and high ethical standards; we always do the right thing.
  • High intellect and ingenuity; we enjoy solving problems, finding a better way, and the challenge of making a difference by improving lives.
  • Structured, organized, detail-oriented, and self-motivated; we approach each day with a detailed plan and excitement to accomplish the day’s objectives while striving to improve ourselves and IE.
  • Accountable; we do what we say and communicative effectively to meet deadlines; we enjoy advancing clinical trials, helping patients, and celebrating success.
  • High standard for excellence; we proof our own work, hold high standards for ourselves and our team, and always prioritize quality above all else.
PHYSICAL REQUIREMENTS

While performing the duties of this position, the employee is regularly required to use hands to finger, handle, or feel; reach with hands and arms and talk and hear. The employee is frequently required to sit. Specific vision abilities required by this job include close vision, color vision, ability to adjust focus.

TRAVEL REQUIREMENTS

N/A

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